Investigating the role of system xc- in glutamate, glutathione and synapse homeostasis in vivo

首席调查员/项目主任(最后、第一、中间)：休伊特，桑德拉·J 答：项目总结：我的实验室试图阐明 细胞死亡和保护以及中枢神经系统的正常生理功能都是由 关注星形胶质细胞-神经元的相互作用和XC-系统的作用。我在两个国家都得到了认可 和国际水平的我的工作使用创新的体外和体内模型和工具，几个 这是我的实验室开发的。我的研究项目一直享受着NINDS的不间断资助 从1997年开始。作为康涅狄格大学健康中心(UCHC-1996-2011)的一名教员，我 成功地培养了三名硕士生、两名博士生和两名医学博士研究生─后两名 在我的实验室完成了他们的研究生培训--以及两名博士后。自从到达锡拉丘兹(2011)以来， 我已经成功培养了三名硕士研究生，一名博士生和三名博士后，不包括 申请人。我还指导了29名本科生--其中近一半来自团体 在STEM中的代表性不足-在我的实验室里，在加入SU后的学年和夏天， 他们中的许多人都被顶尖的理科硕士和博士课程录取[例如，宾夕法尼亚大学(3)，迈阿密大学，德雷克塞尔大学， 作者声明：[Tutts，and Duke]。我成功地协助和/或获得了NIH或其他竞争性奖项 支持我的实习生的职业发展。我的博士生已经攻读了著名的博士后 [例如，耶鲁大学(2)、加州大学洛杉矶分校、加州大学洛杉矶分校、加州大学旧金山分校]。我所有的实习生都留在学术、工业科学或 医药。我最近被告知，我获得了2020年NINDS Landis杰出奖 导师关系，这是本补充材料的基础。 PHS 398/2590(09/04版，2006年4月4日重新发布)页面续格式页面

Principal Investigator/Program Director (Last, First, Middle): Hewett, Sandra J. A. Project Summary: My laboratory seeks to elucidate the molecular and biochemical mechanisms that underlie both cell death and protection as well as the normal physiological function of the CNS with a focus on astrocyte-neuron interactions and the role of System xc-. I am recognized at both the national and international levels for my work using innovative in vitro and in vivo models and tools, several of which my laboratory developed. My research program has enjoyed uninterrupted funding from the NINDS since 1997. While a faculty member at the University of Connecticut Health Center (UCHC - 1996-2011), I successfully trained three Master’s students, two PhD students, and two MD-PhD students─ the latter two performed their graduate training in my laboratory—and two post-docs. Since arriving at Syracuse (2011), I’ve successfully trained three Master’s students, one PhD student and three post-docs, exclusive of the applicant. I also have mentored 29 undergraduates —nearly half of whom are from groups underrepresented in STEM — in my laboratory during the academic year and summers since joining SU, many of whom have matriculated into top M.S and PhD programs [e.g., UPENN (3), U Miami, Drexel, Tufts, and Duke]. I have been successful in facilitating and/or securing NIH or other competitively awarded support for my trainees’ career development. My PhD students have gone on to prestigious post-docs [e.g., Yale (2), UCSD, UCLA, UCSF]. All of my trainees remain in academic, industrial science or medicine. I was recently informed that I have received a 2020 NINDS Landis Award for Outstanding Mentorship, which is the basis for this supplement. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page