Investigating the role of system xc- in glutamate, glutathione and synapse homeostasis in vivo

研究系统 xc- 在体内谷氨酸、谷胱甘肽和突触稳态中的作用

• 批准号: 10214720
• 负责人: SANDRA J HEWETT
• 金额: $ 15万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10214720
• 关键词: Astrocytes; Award; Biochemical; Cell Death; Connecticut; Cytoprotection; Doctor of Philosophy; Faculty; Funding; Glutamates; Glutathione; Health; Homeostasis; In Vitro; Industrialization; International; Laboratories; Medicine; Mentors; Mentorship; Molecular; National Institute of Neurological Disorders and Stroke; Neurons; Physiological; Postdoctoral Fellow; Principal Investigator; Research; Role; Science; Secure; Students; Synapses; System; Training; Underrepresented Groups; United States National Institutes of Health; Universities; Work; career development; doctoral student; in vivo; in vivo Model; innovation; member; programs; tool; undergraduate student

Principal Investigator/Program Director (Last, First, Middle): Hewett, Sandra J. A. Project Summary: My laboratory seeks to elucidate the molecular and biochemical mechanisms that underlie both cell death and protection as well as the normal physiological function of the CNS with a focus on astrocyte-neuron interactions and the role of System xc-. I am recognized at both the national and international levels for my work using innovative in vitro and in vivo models and tools, several of which my laboratory developed. My research program has enjoyed uninterrupted funding from the NINDS since 1997. While a faculty member at the University of Connecticut Health Center (UCHC - 1996-2011), I successfully trained three Master’s students, two PhD students, and two MD-PhD students─ the latter two performed their graduate training in my laboratory—and two post-docs. Since arriving at Syracuse (2011), I’ve successfully trained three Master’s students, one PhD student and three post-docs, exclusive of the applicant. I also have mentored 29 undergraduates —nearly half of whom are from groups underrepresented in STEM — in my laboratory during the academic year and summers since joining SU, many of whom have matriculated into top M.S and PhD programs [e.g., UPENN (3), U Miami, Drexel, Tufts, and Duke]. I have been successful in facilitating and/or securing NIH or other competitively awarded support for my trainees’ career development. My PhD students have gone on to prestigious post-docs [e.g., Yale (2), UCSD, UCLA, UCSF]. All of my trainees remain in academic, industrial science or medicine. I was recently informed that I have received a 2020 NINDS Landis Award for Outstanding Mentorship, which is the basis for this supplement. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

主要研究者/项目负责人（最后，第一，中间）：Hewett，Sandra J. A.项目概述：我的实验室旨在阐明分子和生化机制， 是细胞死亡和保护以及中枢神经系统正常生理功能的基础，具有 专注于星形胶质细胞-神经元的相互作用和系统xc-的作用。我在全国 和国际水平，我的工作使用创新的体外和体内模型和工具， 我的实验室开发的。我的研究项目一直享受着NINDS不间断的资助 自1997年以来当我在康涅狄格大学健康中心（UCHC - 1996-2011）任教时， 成功培养了三名硕士生、两名博士生和两名中博士生，后两名 在我的实验室里完成了他们的研究生培训--还有两个博士后。自从来到锡拉丘兹（2011年）， 我已经成功地培养了三名硕士生，一名博士生和三名博士后， 申请人。我还指导了29名本科生--其中近一半来自团体 在STEM中代表性不足-在我的实验室在学年和夏天，因为加入SU， 他们中的许多人已经被录取进入顶级硕士和博士课程[例如，宾夕法尼亚大学（3），U迈阿密，德雷克塞尔， 塔夫茨和杜克]。我已经成功地促进和/或确保国家卫生研究院或其他竞争性授予 支持我的学员的职业发展。我的博士生们都去了著名的博士后 [e.g., Yale（2），UCSD，UCLA，UCSF].我所有的学员都留在学术，工业科学或 药我最近被告知，我获得了2020年NINDS兰迪斯杰出奖 指导，这是这个补充的基础。 PHS 398/2590（2004年9月修订，2006年4月重新印发）