Investigating the role of system xc- in glutamate, glutathione and synapse homeostasis in vivo

首席研究员/项目总监（最后、第一、中间）：Hewett, Sandra J. A. 项目摘要：我的实验室致力于阐明分子和生化机制 是细胞死亡和保护以及中枢神经系统正常生理功能的基础 重点关注星形胶质细胞-神经元相互作用和系统 xc- 的作用。我在全国都得到认可 我的工作使用创新的体外和体内模型和工具，其中一些 我的实验室开发的。我的研究项目得到了 NINDS 不间断的资助 自 1997 年以来。在康涅狄格大学健康中心 (UCHC - 1996-2011) 任教期间，我 成功培养硕士生3名、博士生2名、博士生2名──后两名 他们和两名博士后在我的实验室进行了研究生培训。自从抵达锡拉丘兹（2011）以来， 我已成功培养了三名硕士生、一名博士生和三名博士后，其中不包括 申请人。我还指导过 29 名本科生，其中近一半来自团体 在加入 SU 后的学年和暑假期间，在我的实验室中，STEM 领域的代表性不足， 其中许多人已被顶尖的硕士和博士课程录取 [例如，UPENN (3)、迈阿密大学、德雷克塞尔大学、 塔夫茨大学和杜克大学]。我已成功促进和/或确保 NIH 或其他竞争性奖项 支持我的学员的职业发展。我的博士生已经继续从事著名的博士后工作 [例如，耶鲁大学 (2)、加州大学圣地亚哥分校、加州大学洛杉矶分校、加州大学旧金山分校]。我所有的学员都留在学术、工业科学或 药。我最近获悉我获得了 2020 年 NINDS Landis 杰出奖 指导，这是本补充的基础。 PHS 398/2590（修订版 09/04，重新发布 4/2006） 页面延续格式页面

Principal Investigator/Program Director (Last, First, Middle): Hewett, Sandra J. A. Project Summary: My laboratory seeks to elucidate the molecular and biochemical mechanisms that underlie both cell death and protection as well as the normal physiological function of the CNS with a focus on astrocyte-neuron interactions and the role of System xc-. I am recognized at both the national and international levels for my work using innovative in vitro and in vivo models and tools, several of which my laboratory developed. My research program has enjoyed uninterrupted funding from the NINDS since 1997. While a faculty member at the University of Connecticut Health Center (UCHC - 1996-2011), I successfully trained three Master’s students, two PhD students, and two MD-PhD students─ the latter two performed their graduate training in my laboratory—and two post-docs. Since arriving at Syracuse (2011), I’ve successfully trained three Master’s students, one PhD student and three post-docs, exclusive of the applicant. I also have mentored 29 undergraduates —nearly half of whom are from groups underrepresented in STEM — in my laboratory during the academic year and summers since joining SU, many of whom have matriculated into top M.S and PhD programs [e.g., UPENN (3), U Miami, Drexel, Tufts, and Duke]. I have been successful in facilitating and/or securing NIH or other competitively awarded support for my trainees’ career development. My PhD students have gone on to prestigious post-docs [e.g., Yale (2), UCSD, UCLA, UCSF]. All of my trainees remain in academic, industrial science or medicine. I was recently informed that I have received a 2020 NINDS Landis Award for Outstanding Mentorship, which is the basis for this supplement. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page