CORE--EPIDEMIOLOGY AND BIOSTATISTICS

本提案是为了继续进行拉什ADCC流行病学研究， 生物统计学核心最近（1995年7月）通过一项 竞争性补充。核心的目标是促进使用 流行病学数据，以解决有关阿尔茨海默氏症的研究问题 疾病核心的基础是由七个现有的数据形成的 流行病学项目。其中三个是当前的ADCC内核：（a） 临床核心，（B）宗教秩序研究核心和（c） 神经病理学核心。四项是独立资助的研究， 与ADCC：（d）芝加哥健康和老龄化项目，一个双年度 人口研究的8,300名居民的地理界定的地区， 芝加哥，目前正处于收集基线数据阶段;（e） 对阿尔茨海默氏症的发展和后果的纵向研究 411名社区老年痴呆症患者中 正在进入第三个数据收集周期， （f）对侵犯性行为的详细纵向研究 阿尔茨海默氏症的行为复杂化的过程， 收集了272名患者每周一次的连续数据， 随访率超过90%;（g）东波士顿研究， 阿尔茨海默病，一组完整的数据集，包括研究 老年痴呆症的流行和发病率， 一个地理上界定的社区的3,800名居民中的疾病 波士顿。 这七个基地项目中有六个从一开始就设计好了 在实质性问题上尽可能相互补充， 各方面的数据，包括标准和程序， 阿尔茨海默病的诊断，认知功能的测量， 评估运动障碍、行为和抑郁症状。的 第七，东波士顿研究，是几年前设计的 但有许多共享的方法和数据元素。芯会 对这七个项目的数据进行综合管理。为 为此，根据项目类型将项目分为三组 参与者与组成的最大群体共享的程度 三个ADCC核心和两项招募参与者的研究 通过这些核心。使用Blaise直接输入计算机数据 系统将支持三个ADCC核心，以及一个关系数据 七个项目的基地将使用统一的程序完成 所有数据集。此外，该核心还将提高 这些数据通过提供来自拉什和其他 合作机构获得技能的机会 为了有效地使用数据，需要以一种适合于 个人调查员的需求。

This proposal is for the continuation of a Rush ADCC Epidemiology and Biostatistics Core that was recently funded (in July, 1995) through a competitive supplement. The goal of the Core is to facilitate use of epidemiological data to address research questions concerning Alzheimer's disease. The base of the core is formed by data from seven existing epidemiological projects. Three of these are current ADCC cores: (a) the Clinical Core, (b)the Religious Orders Study Core and (c) the Neuropathology Core. Four are independently funded studies associated with the ADCC: (d) the Chicago Health and Aging Project, a biracial population study of 8,300 residents of a geographically defined area of Chicago that is currently at the stage of collecting baseline data; (e) a longitudinal study of the progression and consequences of Alzheimer's disease among 411 community-dwelling persons with Alzheimer's disease that is entering its third cycle of data collection with follow-up rates in excess of 95%; (f) a detailed longitudinal study of aggressive behavior complicating the course of Alzheimer's disease that has collected sequential data at weekly intervals for 272 persons with follow-up rates in excess of 90%; and (g)the East Boston studies of Alzheimer's disease, a group of completed data sets comprising studies of prevalent and incident Alzheimer's disease and of the course of the disease among 3,800 residents of a geographically defined neighborhood of Boston. Six of these seven base projects have been designed from the beginning to be as complementary as possible with respect to the substantive aspects of the data in each, including criteria and procedures for the diagnosis of Alzheimer's disease, measurement of cognitive function and assessment of movement disorders, behavior and depressive symptoms. The seventh, the East Boston studies, were designed several years previously but have a number of shared approaches and data elements. The core will provide integrated management of the data from these seven projects. For this purpose the projects are divided into three groups according to the degree to which participants are shared with the largest group composed of the three ADCC cores and the two studies recruiting participants through these cores. Direct computer entry of data using the Blaise system will be supported for the three ADCC cores, and a relational data base for the seven projects will be completed using uniform procedures for all data sets. In addition, the Core will increase the usefulness of these data by offering investigators from Rush and from other collaborating institutions the opportunity to acquire the skills necessary for efficient use of the data in a manner that is tailored to the needs of the individual investigator.