Tweet4Wellness: Development and RCT of Mobile Social Support Groups for Sedentary Behavior Reduction

7.项目概要/摘要 这个K 01职业发展奖将为Marily Oppezzo博士提供密集的监督培训， 建立一个专注于心血管疾病预防的独立研究科学家职业生涯，更多 特别是关于如何改变人们的身体活动水平以促进心脏健康。这一建议建立在博士。 Oppezzo的背景是一个实验主义者，受过学习和行为心理学理论的训练。 改变，并利用斯坦福大学的特殊环境进行高级培训。下 在她的专家团队的指导下，Oppezzo博士将通过一部小说推动行为改变领域的发展。 干预，以减少久坐行为，并有助于久坐行为的影响， 心血管健康久坐是心血管疾病的独立危险因素。健康 坐得太久与有氧运动太少在生理上的影响是不同的。人们越来越 有证据表明，长时间久坐行为导致的心脏病风险可以通过打破久坐来减轻 小时，并在一天中更频繁地移动。该K 01提案将技术用于：1. 减少久坐行为和2.跟踪久坐行为对心血管的影响。1.通过 在一项随机对照试验中，Oppezzo博士将测试一种基于多组分社交媒体的 通过增加步行次数减少长期久坐行为的干预（Tweet 4 Wellness） 一整天在一个私人社交媒体群组中，100天内，参与者将每天收到提示， 以理论为基础的行为改变策略，以获得社会支持和互动周围的久坐 行为目标2.使用非侵入性的腕戴式无线生物传感器收集的数据， 久坐不动的行为将与血压和心率变异性的模式有关。这些数据将 不仅有助于了解心血管生物标志物和久坐行为， 随着时间的推移改变久坐行为对心血管的影响。进行拟议K 01的培训将 解决Oppezzo博士的知识和技能方面的差距，以实现她成为一名 独立科学家：1）临床试验实施和生物传感器“大数据”处理和分析（例如， 加速度计、血压和心率变异性监测数据）; 2）社交媒体和健康 行为干预技术; 3）职业发展技能，如granitary和手稿 出版物。通过课程，实践经验和指导培训，Oppezzo博士将获得 概念和技术基础，以开发和测试有效的心脏健康行为干预措施。 建议项目的结果将直接通知R 01应用程序，该应用程序将建立在成功的 Tweet 4 Wellness干预的功能，改进不太成功的功能，并运行更大规模的临床 在现有心脏病患者中进行试验。总而言之，这款K 01将加速Oppezzo博士的职业生涯 发展和支持使她成为心血管疾病的独立行为科学家 预防

7. Project Summary / Abstract This K01 Career Development Award will provide Dr. Marily Oppezzo with intensive, supervised training to establish an independent research scientist career focusing on cardiovascular disease prevention, more specifically on how to change people’s physical activity levels for heart health. This proposal builds on Dr. Oppezzo’s background as an experimentalist trained in psychological theories of learning and behavior change, and leverages the exceptional environment of Stanford University for advanced training. Under the mentorship of her team of experts, Dr. Oppezzo will advance the field of behavior change with a novel intervention to decrease sedentary behavior, and contribute to the findings of sedentary behavior’s effects on cardiovascular health. Prolonged sitting is an independent risk factor for cardiovascular disease. The health effects of too much sitting are physiologically distinct from those of too little aerobic exercise. There is growing evidence that heart disease risk from prolonged sedentary behavior can be mitigated by breaking up sitting hours and moving more frequently throughout the day. This K01 proposal utilizes technology to both: 1. decrease sedentary behavior and 2. track cardiovascular effects of sedentary behavior. 1. Through a randomized controlled trial, Dr. Oppezzo will test the effectiveness of a multicomponent social media-based intervention (Tweet4Wellness) on decreasing prolonged sedentary behavior by increasing walking bouts throughout the day. Within a private social media group, for 100 days, participants will be prompted with daily, theory-based behavior change strategies to elicit social support and interaction around their sedentary behavior goals. 2. Using collected data from non-invasive, wrist-worn wireless biosensors, real-world patterns of sedentary behavior will be associated with patterns of blood pressure and heart rate variability. This data will not only contribute to what is known about cardiovascular biomarkers and sedentary behavior, but also detect cardiovascular effects of changing sedentary behavior over time. Training to conduct the proposed K01 will address prior gaps in Dr. Oppezzo’s knowledge and skills needed to achieve her long term goal of being an independent scientist: 1) clinical trial implementation and biosensor “big data” processing and analysis (e.g. accelerometer, blood pressure, and heart rate variability monitoring data); 2) social media and health technology for behavioral interventions; 3) career development skills such as grantsmanship and manuscript publications. Through coursework, hands-on experience, and mentored training, Dr. Oppezzo will gain a conceptual and technical foundation to develop and test effective behavioral interventions for heart health. Results from the proposed project will directly inform an R01 application that will build on the successful features of the Tweet4Wellness intervention, refine less successful features, and run a larger, scaled clinical trial in patients with existing heart disease. In summary, this K01 will accelerate Dr. Oppezzo’s career development and support launching her as an independent behavioral scientist in cardiovascular disease prevention.