Tweet4Wellness: Development and RCT of Mobile Social Support Groups for Sedentary Behavior Reduction

7.项目摘要/摘要 这项K01职业发展奖将为玛丽莉·奥佩佐博士提供强化的、有监督的培训，以 建立专注于心血管疾病预防的独立研究科学家职业生涯，更多 特别是关于如何改变人们的体力活动水平以保持心脏健康。这项建议是建立在Dr。 Oppezzo的背景是受过学习和行为心理学理论培训的实验者 变化，并利用斯坦福大学的特殊环境进行高级培训。在.之下 在她的专家团队的指导下，Oppezzo博士将用一本小说来推动行为改变领域的发展 减少久坐行为的干预，并有助于发现久坐行为对 心血管健康。久坐是心血管疾病的独立危险因素。健康 久坐的影响与太少的有氧运动在生理上是不同的。有越来越多的 有证据表明，长时间久坐可以通过打破久坐来减轻心脏病风险 几个小时，一天中移动更频繁。这项K01提案利用技术实现了以下两点：1. 减少久坐行为和2.跟踪久坐行为对心血管的影响。1.通过 随机对照试验，Oppezzo博士将测试基于社交媒体的多组件的有效性 通过增加步行次数减少久坐行为的干预(Tweet4 Wellness) 一整天。在私人社交媒体群中，参与者将在100天内每天收到提示， 基于理论的行为改变策略，以获得社会支持和围绕久坐不动的互动 行为目标。2.使用从非侵入性、手腕佩戴的无线生物传感器、真实世界模式收集的数据 久坐的行为将与血压和心率变异性的模式相关。此数据将 不仅有助于了解心血管生物标记物和久坐行为，而且还检测到 随时间改变久坐行为对心血管的影响。实施拟议的K01的培训将 解决奥佩佐博士在知识和技能方面的不足，以实现她成为一名 独立科学家：1)临床试验实施和生物传感器“大数据”处理和分析(例如 加速计、血压和心率变异性监测数据)；2)社交媒体和健康 用于行为干预的技术；3)职业发展技能，如资质和手稿 出版物。通过课程学习、实践经验和指导培训，Oppezzo博士将获得 为开发和测试有效的心脏健康行为干预措施奠定了概念和技术基础。 建议项目的结果将直接通知R01应用程序，该应用程序将在成功的 Tweet4Wellness干预的功能，改进不太成功的功能，并运行更大规模的临床 在现有心脏病患者中进行试验。总而言之，这款K01将加速奥佩佐博士的职业生涯 发展和支持她成为心血管疾病领域的独立行为科学家 预防。

7. Project Summary / Abstract This K01 Career Development Award will provide Dr. Marily Oppezzo with intensive, supervised training to establish an independent research scientist career focusing on cardiovascular disease prevention, more specifically on how to change people’s physical activity levels for heart health. This proposal builds on Dr. Oppezzo’s background as an experimentalist trained in psychological theories of learning and behavior change, and leverages the exceptional environment of Stanford University for advanced training. Under the mentorship of her team of experts, Dr. Oppezzo will advance the field of behavior change with a novel intervention to decrease sedentary behavior, and contribute to the findings of sedentary behavior’s effects on cardiovascular health. Prolonged sitting is an independent risk factor for cardiovascular disease. The health effects of too much sitting are physiologically distinct from those of too little aerobic exercise. There is growing evidence that heart disease risk from prolonged sedentary behavior can be mitigated by breaking up sitting hours and moving more frequently throughout the day. This K01 proposal utilizes technology to both: 1. decrease sedentary behavior and 2. track cardiovascular effects of sedentary behavior. 1. Through a randomized controlled trial, Dr. Oppezzo will test the effectiveness of a multicomponent social media-based intervention (Tweet4Wellness) on decreasing prolonged sedentary behavior by increasing walking bouts throughout the day. Within a private social media group, for 100 days, participants will be prompted with daily, theory-based behavior change strategies to elicit social support and interaction around their sedentary behavior goals. 2. Using collected data from non-invasive, wrist-worn wireless biosensors, real-world patterns of sedentary behavior will be associated with patterns of blood pressure and heart rate variability. This data will not only contribute to what is known about cardiovascular biomarkers and sedentary behavior, but also detect cardiovascular effects of changing sedentary behavior over time. Training to conduct the proposed K01 will address prior gaps in Dr. Oppezzo’s knowledge and skills needed to achieve her long term goal of being an independent scientist: 1) clinical trial implementation and biosensor “big data” processing and analysis (e.g. accelerometer, blood pressure, and heart rate variability monitoring data); 2) social media and health technology for behavioral interventions; 3) career development skills such as grantsmanship and manuscript publications. Through coursework, hands-on experience, and mentored training, Dr. Oppezzo will gain a conceptual and technical foundation to develop and test effective behavioral interventions for heart health. Results from the proposed project will directly inform an R01 application that will build on the successful features of the Tweet4Wellness intervention, refine less successful features, and run a larger, scaled clinical trial in patients with existing heart disease. In summary, this K01 will accelerate Dr. Oppezzo’s career development and support launching her as an independent behavioral scientist in cardiovascular disease prevention.