Obesity and Alzheimer's Disease

肥胖和阿尔茨海默病

• 批准号: 7241454
• 负责人: DEBORAH R. GUSTAFSON
• 金额: $ 6.25万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7241454
• 关键词: Adult; Age; Aged, 80 and over; Aging; Alteplase; Alzheimer' s Disease; Alzheimer' s disease risk; Angiotensin Receptor; Angiotensins; Apolipoprotein E; Area; Birth; Blood Pressure; Blood Vessels; Body Weight; Body mass index; Brain Pathology; Catechols; Cessation of life; Clinical; Data; Dementia; Disease; Disruption; Elderly; Energy Metabolism; Epidemic; Etiology; Europe; Evaluation; Feminization; Future; Genes; Genetic; Genetic Polymorphism; Genotype; Goals; Health; Homeostasis; Hormones; Hunger; Hypothalamic structure; Length; Life Cycle Stages; Longevity; Longitudinal Studies; Measurement; Mental disorders; Methylenetetrahydrofolate reductase (NADPH); Morbidity - disease rate; Obesity; Onset of illness; Overweight; Participant; Pattern; Peptidyl-Dipeptidase A; Physical activity; Population; Population Study; Prevalence; Publications; Rate; Regulation; Relative (related person); Reporting; Research; Risk; Risk Factors; Role; Satiation; Societies; Sweden; Time; Transferase; United States; Variant; Weight; Woman; age group; age related; base; blood lipid; cohort; critical developmental period; design; follow-up; genetic risk factor; intervention program; men; mortality; neuropathology; prospective

DESCRIPTION (provided by applicant): Obesity is associated with Alzheimer's disease (AD), particularly in women. However, changes in body weight and body mass index (BMI) throughout the progressive course of AD have also been reported, resulting in a low body weight or low BMI predicting mortality among those who have the disease. Thus, temporal changes in body weight and BMI may not only influence AD risk, but also progression, and ultimately death. The role of BMI in AD also underscores the importance of timing of risk factors, both in relationship to disease onset and whether they occur in early-, mid-, or late-life; and illustrates the change in direction of risk factor-disease relationships that may occur at certain points in late life. The goals of this project are to evaluate the role of BMI and related vascular and genetic factors in relationship to AD in three population-based, longitudinal studies containing epidemiologic, clinical, and biologic data related to psychiatric disorders of aging that are unsurpassed in the world. We propose to: 1) Characterize the role of overweight and obesity in AD and other dementias in women and men across three population-based studies in Goteborg, Sweden. Participants in these studies, born between 1901 and 1930, have been followed prospectively from baseline ages of 38 to 70, and 95 years. 2) Evaluate the role of overweight and obesity in AD and other dementias with consideration for 'critical periods' of adiposity exposure, the length of time between an adiposity measurement and onset of dementia, the role of current overweight and obesity outpoints in relationship to dementia risk, and examination of risk factors by age group with consideration for birth cohort. 3) Assess the role of genetic polymorphisms related to the vascular etiology of AD and other dementias, and their potential interaction with obesity. 4) Consider physical activity and other vascular risk factors, such as blood pressure and blood lipids, and their potential interaction with obesity and genetic factors to modulate risk for AD and other dementias. Understanding the life course of overweight and obesity in relationship to dementia will assist the future design of tailor-made intervention programs based on age and previous weight patterns, and assist in the evaluation of better outpoints for overweight and obesity that optimize health in the oldest age groups.

描述（由申请人提供）：肥胖与阿尔茨海默病（AD）有关，尤其是女性。然而，在阿尔茨海默病的整个进展过程中，体重和体重指数（BMI）的变化也有报道，导致低体重或低BMI预测疾病患者的死亡率。因此，体重和BMI的时间变化不仅可能影响AD的风险，还可能影响AD的进展，最终导致死亡。BMI在AD中的作用也强调了风险因素时机的重要性，既与疾病发病有关，也与疾病发生在早期、中期还是晚期有关；并说明了风险因素与疾病关系方向的变化可能发生在晚年的某些时候。该项目的目标是评估BMI和相关血管和遗传因素在AD相关的三个基于人群的纵向研究中的作用，这些研究包含与世界上无与伦比的老龄精神疾病相关的流行病学，临床和生物学数据。我们建议：1)通过瑞典哥德堡的三项基于人群的研究，描述超重和肥胖在女性和男性AD和其他痴呆症中的作用。这些研究的参与者出生于1901年至1930年之间，从38岁到70岁以及95岁的基线年龄进行了前瞻性随访。2)评估超重和肥胖在AD和其他痴呆中的作用，考虑到肥胖暴露的“关键时期”、肥胖测量和痴呆发病之间的时间长度、当前超重和肥胖终点与痴呆风险的关系，以及考虑到出生队列，按年龄组检查危险因素。3)评估与AD和其他痴呆的血管病因相关的遗传多态性的作用，以及它们与肥胖的潜在相互作用。4)考虑体力活动和其他血管危险因素，如血压和血脂，以及它们与肥胖和遗传因素的潜在相互作用，以调节AD和其他痴呆症的风险。了解超重和肥胖与痴呆之间的关系，将有助于未来设计基于年龄和既往体重模式的量身定制的干预方案，并有助于评估超重和肥胖的更好的终点，从而优化老年群体的健康。

项目成果

The prevalence of psychotic symptoms and paranoid ideation in non-demented population samples aged 70-82 years.

70-82 岁非痴呆人群样本中精神病症状和偏执观念的患病率。

• DOI: 10.1002/gps.2278
• 发表时间: 2009
• 期刊: International journal of geriatric psychiatry
• 影响因子: 4
• 作者: Sigstrom,Robert;Skoog,Ingmar;Sacuiu,Simona;Karlsson,Bjorn;Klenfeldt,IsakFreden;Waern,Margda;Gustafson,Deborah;Ostling,Svante
• 通讯作者: Ostling,Svante

Obesity and dementia: adipokines interact with the brain.

肥胖和痴呆：脂肪因子与大脑相互作用。

• DOI: 10.1016/j.euroneuro.2014.03.002
• 发表时间: 2014-12
• 期刊: EUROPEAN NEUROPSYCHOPHARMACOLOGY
• 影响因子: 5.6
• 作者: Arnoldussen, Ilse A. C.;Kiliaan, Amanda J.;Gustafson, Deborah R.
• 通讯作者: Gustafson, Deborah R.

A population-based study on phobic fears and DSM-IV specific phobia in 70-year olds.

一项针对 70 岁老年人的恐惧症和 DSM-IV 特定恐惧症的人群研究。

• DOI: 10.1016/j.janxdis.2010.08.014
• 发表时间: 2011
• 期刊: Journal of anxiety disorders
• 影响因子: 10.3
• 作者: Sigstrom,Robert;Ostling,Svante;Karlsson,Bjorn;Waern,Margda;Gustafson,Deborah;Skoog,Ingmar
• 通讯作者: Skoog,Ingmar

Is there a CSF biomarker profile related to depression in elderly women?

• DOI: 10.1016/j.psychres.2008.11.012
• 发表时间: 2010-04-30
• 期刊: PSYCHIATRY RESEARCH
• 影响因子: 11.3
• 作者: Gudmundsson, Pia;Skoog, Ingmar;Gustafson, Deborah
• 通讯作者: Gustafson, Deborah