Psychosocial and Neighborhood Mechanisms and Consequences of Black-White Sleep Disparities on Cognition

心理社会和邻里机制以及黑白睡眠差异对认知的影响

• 批准号: 10216569
• 负责人: Alyssa Ann Gamaldo
• 金额: $ 134.2万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216569
• 关键词: Address; Adult; African American; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Behavioral; Biological Markers; Brain; Buffers; Chronic; Clinical; Cognition; Cognitive; Coupling; Data; Disease; Evidence based intervention; Financial Hardship; Funding; Goals; Health; Impaired cognition; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Investigation; Life; Life Cycle Stages; Link; Longevity; Measures; Mediating; Mediator of activation protein; Mission; Modeling; Morbidity - disease rate; Neighborhoods; Neuropsychology; Participant; Pathway interactions; Performance; Policies; Population Study; Process; Psychosocial Factor; Psychosocial Stress; Public Health; Race; Research; Research Personnel; Risk; Role; Sampling; Sleep; Sleep Deprivation; Sleep Fragmentations; Sleep disturbances; Social support; Specific qualifier value; Spirituality; Synaptic plasticity; Testing; Time; United States National Institutes of Health; adequate sleep; behavioral pharmacology; black/white disparity; brain health; cognitive function; cognitive performance; cognitive testing; cohesion; contextual factors; coping; cytokine; dementia risk; design; evidence base; experience; glymphatic system; health difference; health disparity; healthy aging; high risk; improved; innovation; interest; middle age; mild cognitive impairment; mortality; neuroinflammation; novel; poor sleep; protective factors; psychosocial; racial difference; racial disparity; resilience; sleep health; social disadvantage; socioeconomics; stressor

Project Summary Black-White differences have been observed in cognitive performance and risk for cognitive impairment, particularly Alzheimer’s disease and related dementias (ADRD). Few studies have examined how sleep may further explain these disparities, especially considering that sleep disturbances are common in Blacks. Since disparities in cognition and sleep have been observed in middle-aged adults, this portion of the lifespan is ideal to investigate the association between sleep and cognitive decline as well as the underlying psychosocial, contextual, and biomarker factors that influence sleep and/or cognitive Black-White disparities. Every year for 4 years, the proposed study will collect measures of sleep duration and quality, cognitive functioning, inflammatory biomarkers (e.g., CRP, IL-6), life stressors, and resilience factors (e.g., spirituality, coping) in a sample of middle- aged Black and White participants from the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study. The overall objective of this study is to identify mechanisms of Black-White sleep disparities and the mechanisms that account for Black- White differences in ADRD risk. The central hypothesis is that racial disparities in sleep will be associated with racial disparities in cognitive decline. Guided by the investigators’ previous research, three specific aims will be tested: 1) To determine if there are racial differences in the daily coupling of sleep and mobile cognitive performance and whether differences in this coupling are moderated by life stressors (e.g., financial strain and neighborhood disorder); 2) To test longitudinal associations among sleep and performance on mobile cognitive assessments and explore the role of life stressors, protective factors (e.g., spirituality and neighborhood cohesion) and inflammation; 3) To determine whether changes in the strength of the daily coupling of sleep and performance on mobile cognitive assessments relate to racial differences in traditional clinical measures of cognitive decline over 4 years, and to elucidate the potential mediational role of inflammation. This approach is innovative because it will not only examine the association between sleep and cognitive functioning over time, but will also examine the relationship of life stressors, sleep, inflammatory biomarkers, and/or resilient factors on racial disparities in cognitive decline. The proposed research is significant because of its potential to identify psychosocial and contextual factors related to impaired sleep and cognition that could serve as the basis for evidence-based behavioral or policy interventions.

项目摘要 黑人和白人在认知表现和风险方面的差异被观察到 认知障碍，特别是阿尔茨海默病和相关痴呆(ADRD)。 很少有研究研究睡眠如何进一步解释这些差异，尤其是 考虑到睡眠障碍在黑人中很常见。因为认知上的差异 和睡眠都是在中年人身上观察到的，这部分寿命是理想的 调查睡眠和认知能力下降之间的联系以及潜在的 影响睡眠和/或认知的心理社会、背景和生物标记因素 黑人和白人之间的差距。在四年的时间里，拟议的研究每年都会收集措施 睡眠时间和质量、认知功能、炎症生物标志物(例如，CRP， IL-6)、生活压力源和韧性因素(如灵性、应对)。 来自多元化社区健康老龄化的老年黑人和白人参与者 跨越寿命(HANDLS)研究。这项研究的总体目标是确定 黑白睡眠差异的机制和解释黑白睡眠差异的机制 白人在ADRD风险上的差异。中心假设是睡眠中的种族差异 会与认知能力下降中的种族差异有关。在调查人员的指导下 在之前的研究中，将测试三个具体目的：1)确定是否存在种族差异 睡眠和移动认知表现的日常耦合的差异以及是否 这种耦合的差异被生活压力因素(例如，经济压力和 邻里关系障碍)；2)测试睡眠和睡眠之间的纵向联系 在移动认知评估中的表现，并探索生活压力源的作用， 保护性因素(如灵性和社区凝聚力)和炎症；3) 以确定睡眠和表现的日常耦合强度是否发生变化 关于传统临床测量中与种族差异有关的移动认知评估 4年来认知能力下降的情况，并阐明炎症的潜在中介作用。 这种方法是创新的，因为它不仅将检查 睡眠和认知功能随着时间的推移，还会考察生活的关系 应激源、睡眠、炎症性生物标志物和/或弹性因素对种族差异的影响 认知能力下降。这项拟议的研究具有重要意义，因为它具有识别 与睡眠和认知受损有关的心理社会和背景因素 作为基于证据的行为或政策干预的基础。