Bayesian Modeling for Prenatal, Natal and Postnatal Predictors of Developmental Defects of Enamel in Primary Maxillary Central Incisor Teeth

上颌中切牙牙釉质发育缺陷的产前、产中和产后预测因子的贝叶斯模型

• 批准号: 10216219
• 负责人: Andrew B. Lawson
• 金额: $ 14.7万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216219
• 关键词: 1 year old; 5 year old; Address; Affect; Age-Months; Anterior; Apgar Score; Area; Bayesian Modeling; Birth; Calcium; Child; Cholecalciferol; Clinical; Clinical Trials; Cosmetics; Data; Data Analyses; Data Collection; Data Set; Defect; Dental; Dental Enamel; Dental Enamel Hypoplasia; Dental caries; Dental crowns; Development; Diet; Dietary Calcium; Disease; Double-Blind Method; Enamel Formation; Esthetics; Etiology; Expenditure; Fluorides; Follow-Up Studies; Future; General Anesthesia; Goals; Homeostasis; Hormones; Human; Hypocalcemia result; Image; Incisor; Infant; Infection; Intervention Studies; Joints; Knowledge; Learning; Low Birth Weight Infant; Maxilla; Methodology; Minerals; Modeling; Monitor; Mothers; National Institute of Dental and Craniofacial Research; Oral; Oral cavity; Oral health; Outcome; Parathyroid gland; Pharmaceutical Preparations; Phosphorus; Poverty; Predictive Factor; Pregnancy; Prenatal care; Prevalence; Prevention; Primary Dentition; Prospective Studies; Randomized; Research Project Grants; Risk; Structure; Supplementation; Testing; Tetracyclines; Time; Tooth Attrition; Tooth structure; Vitamin D; Vitamin D Deficiency; Weight; absorption; acquired factor; aged; calcification; cariogenic bacteria; cost; cost effective; data resource; deciduous tooth; design; early childhood; federal poverty level; genetic information; high risk; human model; indexing; infancy; maternal cigarette smoking; novel; outcome prediction; permanent tooth; postnatal; premature; prenatal; secondary analysis; social health determinants; validation studies

Project Abstract Developmental defects of enamel or DDE include enamel hypoplasia (EH), opacities (OP) and post-eruptive breakdown (PEB). DDE are defects in the structural integrity of the tooth that happen while the tooth is developing. EH is characterized by an area of less enamel and is a quantitative defect. OP are characterized as an area with a difference in translucency and are a qualitative defect. PEB is the loss of enamel after the tooth erupts into the mouth. DDE are a problem because EH can put the tooth at higher risk for dental caries, and both OP and PEB can be esthetic problems. The goal of our proposed study is to identify clinical and other factors, and the timing of these factors that result in DDE of primary maxillary central incisor teeth. Our hypothesis is that these predictors for DDE are related to calcium homeostasis. This study builds on our prior study which found pregnancy and birth factors related to calcium homeostasis that were predictive for EH. We now propose a more extensive study of the impact of maternal pregnancy factors, birth factors and early infancy factors on the development of DDE in the deciduous maxillary central incisor teeth. We study DDE in these two teeth because they begin calcification at 13-15 weeks of gestation, complete calcification by 4-6 weeks postnatal, and erupt at about 1 year of age. The enamel crowns of these two teeth serve as an irreversible record of pregnancy, birth and early infancy exposures. A best test of the cause-effect of maternal, birth and early infancy related factors is a prospective study of mothers with monthly monitoring of factors during pregnancy, at birth, then at early infancy and also following the children to examine their teeth which erupt into the oral cavity at about 1 year of age. We are uniquely poised to conduct secondary analyses of existing data resources so that we can identify the predictors and timing for these predictors during human tooth development and resultant DDE. We will compare and contrast the predictors for the different DDE outcomes to learn more about their development. We will develop Bayesian models that identify the predictors and their timing for DDE outcomes. The results of this study of existing data resources are designed to close the gap in knowledge about possibly modifiable predictors and also to provide an analytical approach to identify pregnancy, birth and early infancy predictors for DDE in the child. Results will also help with the design of future validation and intervention studies.

项目摘要 釉质发育缺陷或DDE包括釉质发育不良(EH)、浑浊(OP)和萌出后 分解(PEB)。DDE是牙齿结构完整性的缺陷，发生在牙齿 发展中的。EH的特点是釉质较少，是一种数量缺陷。OP的特征是 作为一个区域与半透明的不同，是一个质的缺陷。PEB是牙釉质修复后的损失 牙齿长到嘴里。DDE是一个问题，因为EH会使牙齿面临更高的龋齿风险， OP和PEB都可能是审美问题。我们提议的研究的目标是确定临床和其他 上颌乳中切牙发生DDE的因素，以及这些因素发生的时机。我们的 假说是DDE的这些预测因子与钙稳态有关。这项研究建立在我们以前的基础上 一项研究发现，妊娠和出生因素与钙稳态有关，可以预测EH。我们 现在建议更广泛地研究影响产妇怀孕因素、生育因素和早产的因素 婴儿期因素对上颌中切牙乳牙发育的影响我们在研究DDE 这两颗牙齿在怀孕13-15周时开始钙化，4-6周时完全钙化。 出生后几周，在大约1岁时喷发。这两颗牙的釉质冠起到了 不可逆转的怀孕、分娩和婴儿早期接触记录。对母体的因果关系的最好检验， 出生和早期婴儿相关因素是一项对母亲进行每月监测的前瞻性研究 在怀孕期间，在出生时，然后在婴儿期早期，也跟随孩子检查他们的牙齿 在大约1岁的时候喷发到口腔中。我们独一无二地准备进行二级分析 现有的数据资源，以便我们可以在人工操作期间确定这些预测值的预测值和时间 牙齿发育和由此产生的DDE。我们将对不同DDE的预测值进行比较和对比 结果，以了解更多关于其发展的情况。我们将开发贝叶斯模型来识别预测因素 以及他们对DDE结果的时机。这项对现有数据资源的研究结果旨在关闭 关于可能可修改的预测因素的知识差距，以及提供一种分析方法来 确定妊娠、出生和婴儿早期阶段对儿童发生DDE的预测因素。结果也将有助于设计 未来的验证和干预研究。