The University of Iowa's Regional Stroke Research Network

爱荷华大学区域中风研究网络

• 批准号: 10216369
• 负责人: ENRIQUE Carlos LEIRA
• 金额: $ 29.81万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216369
• 关键词: Academic Medical Centers; Acute; Agreement; American; Aneurysm; Assessment tool; Benchmarking; Businesses; Caring; Cerebrovascular Disorders; Classification; Clinical; Clinical Trials; Communities; Community Hospitals; Consent; Development; Engineering; Enrollment; Epidemiologist; Funding; Geographic Locations; Geography; Goals; Grant; Growth; Hospitals; Infrastructure; Institution; Institutional Review Boards; Intervention; Iowa; Iowan; Leadership; Location; Medicine; Midwestern United States; Mind; Mission; Modernization; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Nebraska; North Dakota; Operative Surgical Procedures; Outcome; Patient Recruitments; Patient-Focused Outcomes; Patients; Phase; Population; Positioning Attribute; Prevention; Protocols documentation; Recovery; Research; Research Infrastructure; Research Personnel; Research Proposals; Role; Rural; Site; Specialist; Stroke; Stroke prevention; StrokeNet trials; Subarachnoid Hemorrhage; Testing; Time; TimeLine; Training; Training and Education; Translational Research; Trust; United States National Institutes of Health; Universities; Work; acute stroke; bench to bedside; cerebrovascular; college; critical access hospital; health disparity; improved; improved outcome; innovation; multidisciplinary; natural hypothermia; next generation; novel strategies; organizational structure; phase III trial; pragmatic trial; recruit; rural patients; rural underserved; stroke intervention; stroke therapy; stroke trials; translational scientist; underserved area; working group

The University of Iowa (UI) Regional Stroke Research Network meets the goal of NIH StrokeNet in maximizing efficiencies to develop, promote, and conduct high quality multi-site clinical trials testing promising interventions in stroke prevention, treatment, and recovery. The current proposal builds on the rich tradition of the UI as a leader in both developing and conducting NINDS-sponsored research, The long-term goal of this proposal is to improve the outcomes of the 800,000 Americans who suffer a stroke every year, particularly those subjected to disparities in health outcomes due to geographically underserved areas. Our proposal's immediate goals are to improve the collective network recruitment efficiency and generalizability of NINDS- sponsored trials by facilitating enrollment of subjects with geographical barriers to participation. Specifically, we aim to increase the number of efficient stroke interventions that can be applied to the vast majority of patients in the US. With that goal in mind, we propose to maintain the UIRCC as an Upper Midwest regional research network efficient in recruiting subjects in NINDS- funded stroke trials. The UIRCC is an already operational infrastructure of 14 trial-ready hospitals in Iowa, Nebraska, and North Dakota that enables enrollment of Americans that have been traditionally challenging to include in trials due to their geographically location. At the same time, the UIRCC will continue to engage a multidisciplinary team of translational researchers to generate innovative research proposals that will lead to multicenter clinical trials through StrokeNet.

爱荷华大学(UI)区域卒中研究网络满足NIH卒中网络的目标 最大限度地提高效率，以开发、推广和进行高质量的多点临床试验 在中风的预防、治疗和康复方面测试有前景的干预措施。海流 提案建立在用户界面作为开发和实施领导者的丰富传统之上 NINDS赞助的研究，这项提议的长期目标是改善 每年有80万美国人中风，特别是那些遭受差异的人 由于地理上服务不足的地区，对健康结果的影响。我们的提案的近期目标 就是要提高NINDS的集体网络招聘效率和通用性-- 通过促进有地域障碍的受试者的入学来赞助试验。 具体地说，我们的目标是增加可以应用的有效中风干预的数量 对美国的绝大多数患者来说。考虑到这一目标，我们建议维持 UIRCC作为上中西部地区研究网络，有效地在NINDS- 资助中风试验。UIRCC是一个已经投入运营的基础设施，有14个已做好试用准备 爱荷华州、内布拉斯加州和北达科他州的医院，允许有 由于它们的地理位置，传统上要纳入试验是有挑战性的。同时 时间，UIRCC将继续聘请一个多学科的翻译研究团队来 产生创新的研究建议，通过以下方式实现多中心临床试验 StrokeNet。