The University of Iowa's Regional Stroke Research Network

爱荷华大学区域中风研究网络

• 批准号: 10216369
• 负责人: ENRIQUE Carlos LEIRA
• 金额: $ 29.81万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216369
• 关键词: Academic Medical Centers; Acute; Agreement; American; Aneurysm; Assessment tool; Benchmarking; Businesses; Caring; Cerebrovascular Disorders; Classification; Clinical; Clinical Trials; Communities; Community Hospitals; Consent; Development; Engineering; Enrollment; Epidemiologist; Funding; Geographic Locations; Geography; Goals; Grant; Growth; Hospitals; Infrastructure; Institution; Institutional Review Boards; Intervention; Iowa; Iowan; Leadership; Location; Medicine; Midwestern United States; Mind; Mission; Modernization; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Nebraska; North Dakota; Operative Surgical Procedures; Outcome; Patient Recruitments; Patient-Focused Outcomes; Patients; Phase; Population; Positioning Attribute; Prevention; Protocols documentation; Recovery; Research; Research Infrastructure; Research Personnel; Research Proposals; Role; Rural; Site; Specialist; Stroke; Stroke prevention; StrokeNet trials; Subarachnoid Hemorrhage; Testing; Time; TimeLine; Training; Training and Education; Translational Research; Trust; United States National Institutes of Health; Universities; Work; acute stroke; bench to bedside; cerebrovascular; college; critical access hospital; health disparity; improved; improved outcome; innovation; multidisciplinary; natural hypothermia; next generation; novel strategies; organizational structure; phase III trial; pragmatic trial; recruit; rural patients; rural underserved; stroke intervention; stroke therapy; stroke trials; translational scientist; underserved area; working group

The University of Iowa (UI) Regional Stroke Research Network meets the goal of NIH StrokeNet in maximizing efficiencies to develop, promote, and conduct high quality multi-site clinical trials testing promising interventions in stroke prevention, treatment, and recovery. The current proposal builds on the rich tradition of the UI as a leader in both developing and conducting NINDS-sponsored research, The long-term goal of this proposal is to improve the outcomes of the 800,000 Americans who suffer a stroke every year, particularly those subjected to disparities in health outcomes due to geographically underserved areas. Our proposal's immediate goals are to improve the collective network recruitment efficiency and generalizability of NINDS- sponsored trials by facilitating enrollment of subjects with geographical barriers to participation. Specifically, we aim to increase the number of efficient stroke interventions that can be applied to the vast majority of patients in the US. With that goal in mind, we propose to maintain the UIRCC as an Upper Midwest regional research network efficient in recruiting subjects in NINDS- funded stroke trials. The UIRCC is an already operational infrastructure of 14 trial-ready hospitals in Iowa, Nebraska, and North Dakota that enables enrollment of Americans that have been traditionally challenging to include in trials due to their geographically location. At the same time, the UIRCC will continue to engage a multidisciplinary team of translational researchers to generate innovative research proposals that will lead to multicenter clinical trials through StrokeNet.

爱荷华大学 (UI) 区域中风研究网络实现 NIH StrokeNet 的目标 最大限度地提高开发、促进和开展高质量多中心临床试验的效率 测试中风预防、治疗和康复方面有前景的干预措施。目前的 该提案建立在 UI 作为开发和执行领导者的丰富传统之上 NINDS 赞助的研究，该提案的长期目标是改善 每年有 800,000 名美国人遭受中风，尤其是那些遭受不平等待遇的美国人 由于地理上服务不足的地区而导致健康结果。我们提案的近期目标 旨在提高 NINDS 的集体网络招聘效率和通用性 通过促进有地理参与障碍的受试者入组来赞助试验。 具体来说，我们的目标是增加可应用的有效中风干预措施的数量 为美国绝大多数患者提供服务。考虑到这一目标，我们建议维持 UIRCC 作为中西部地区的研究网络，在 NINDS 中有效招募受试者- 资助中风试验。 UIRCC 是一个已经投入运行的基础设施，拥有 14 个可供试用的基础设施 爱荷华州、内布拉斯加州和北达科他州的医院允许患有以下疾病的美国人入学 由于其地理位置，传统上很难将其纳入试验。同时 届时，UIRCC 将继续聘请多学科的转化研究人员团队 产生创新的研究提案，通过以下方式进行多中心临床试验 中风网。