The University of Iowa's Regional Stroke Research Network

爱荷华大学区域中风研究网络

• 批准号: 10593653
• 负责人: ENRIQUE Carlos LEIRA
• 金额: $ 29.81万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10593653
• 关键词: Academic Medical Centers; Acute; Agreement; American; Aneurysm; Assessment tool; Benchmarking; Businesses; Caring; Cerebrovascular Disorders; Classification; Clinical; Clinical Trials; Communities; Community Hospitals; Consent; Development; Engineering; Enrollment; Epidemiologist; Funding; Geographic Locations; Geography; Goals; Grant; Growth; Hospitals; Infrastructure; Institution; Institutional Review Boards; Intervention; Iowa; Iowan; Leadership; Location; Medicine; Midwestern United States; Mind; Mission; Modernization; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Nebraska; North Dakota; Operative Surgical Procedures; Outcome; Patient Recruitments; Patient-Focused Outcomes; Patients; Phase; Population; Positioning Attribute; Prevention; Protocols documentation; Recovery; Research; Research Infrastructure; Research Personnel; Research Proposals; Role; Rural; Site; Specialist; Stroke; Stroke prevention; StrokeNet trials; Subarachnoid Hemorrhage; Testing; Time; TimeLine; Training; Training and Education; Translational Research; Trust; United States National Institutes of Health; Universities; Work; acute stroke; bench to bedside; cerebrovascular; college; critical access hospital; geographic barrier; health disparity; improved; improved outcome; innovation; multidisciplinary; natural hypothermia; next generation; novel strategies; organizational structure; phase III trial; pragmatic trial; recruit; rural patients; rural underserved; stroke intervention; stroke therapy; stroke trials; translational scientist; underserved area; working group

The University of Iowa (UI) Regional Stroke Research Network meets the goal of NIH StrokeNet in maximizing efficiencies to develop, promote, and conduct high quality multi-site clinical trials testing promising interventions in stroke prevention, treatment, and recovery. The current proposal builds on the rich tradition of the UI as a leader in both developing and conducting NINDS-sponsored research, The long-term goal of this proposal is to improve the outcomes of the 800,000 Americans who suffer a stroke every year, particularly those subjected to disparities in health outcomes due to geographically underserved areas. Our proposal's immediate goals are to improve the collective network recruitment efficiency and generalizability of NINDS- sponsored trials by facilitating enrollment of subjects with geographical barriers to participation. Specifically, we aim to increase the number of efficient stroke interventions that can be applied to the vast majority of patients in the US. With that goal in mind, we propose to maintain the UIRCC as an Upper Midwest regional research network efficient in recruiting subjects in NINDS- funded stroke trials. The UIRCC is an already operational infrastructure of 14 trial-ready hospitals in Iowa, Nebraska, and North Dakota that enables enrollment of Americans that have been traditionally challenging to include in trials due to their geographically location. At the same time, the UIRCC will continue to engage a multidisciplinary team of translational researchers to generate innovative research proposals that will lead to multicenter clinical trials through StrokeNet.

爱荷华州大学（UI）区域卒中研究网络符合NIH StrokeNet的目标 在最大限度地提高效率，开发，促进和进行高质量的多中心临床试验 在中风的预防、治疗和康复方面测试有希望的干预措施。当前 该提案建立在UI作为开发和执行领导者的丰富传统之上 NINDS赞助的研究，该提案的长期目标是改善 每年有80万美国人中风，特别是那些受到不平等待遇的人， 由于地理上服务不足的地区，我们提案的近期目标 是为了提高NINDS的集体网络招聘效率和推广性- 通过促进有地理障碍的受试者入组申办试验。 具体来说，我们的目标是增加有效的中风干预措施的数量， 在美国的绝大多数患者。基于这个目标，我们建议维持 UIRCC作为一个上中西部地区的研究网络，在NINDS中有效招募受试者- 资助的中风试验UIRCC是一个已经运作的基础设施， 爱荷华州、内布拉斯加州和北达科他州的医院， 由于其地理位置，传统上纳入试验具有挑战性。在同一 同时，UIRCC将继续聘请多学科的翻译研究人员团队， 产生创新的研究建议，将导致多中心临床试验，通过 中风网。