The University of Iowa's Statewide Stroke Research Network

描述（由申请人提供）：爱荷华大学（Ul）全州卒中研究网络满足NINDS卒中试验网络的目标，即在卒中预防、治疗和康复方面，最大限度地提高开发、促进和开展高质量多站点临床试验的效率。目前的提案建立在Ul作为开发和开展ninds资助的研究的领导者的丰富传统以及Ul作为新的综合医疗保健网络- Ul健康联盟中心的作用的基础上。该提案的长期目标是提高开展I - III期脑卒中试验的效率，并确保有一支训练有素的临床研究者队伍来领导此类试验。该提案的直接目标是建立一个扩大的全州范围的研究网络，用于开展中风试验，以覆盖服务不足的农村患者，这些患者目前由于地理障碍而无法参加中风试验，并且健康结果存在差异。拟议中的爱荷华大学区域协调中心（UIRCC）代表了一个全面和集成的基础设施，用于开展试验，将医疗保健提供者、医院管理人员、临床和卫生服务调查员、公共卫生官员和患者倡导者聚集在一起。UIRCC包括一个网络，将Ul的研究能力扩展到12个可供试验的站点。这些医院将由全州范围内的轮辐基础设施提供，这将允许在关键医院首先评估的美国人的审判中有足够的代表。UIRCC将利用PI先前的工作，改善在关键医院就诊的患者的招募工作，并最大限度地扩大患者的地理覆盖范围。这种方法的可行性得到了正在进行的研究数据共享合作的支持，以及来自全州医疗保健联盟的强有力的机构支持。我们已经有计划将这种全州网络模式扩展到内布拉斯加州和达科他州。UIRCC还将开发创新的转化研究提案，通过NINDS卒中网络将临床医生、早期（即从实验室到床边）转化研究人员、临床试验学家、流行病学家、生物统计学家和地理学家聚集在一起，开发利用创新方法（例如适应性和实用试验设计）的卒中治疗、康复和预防新方法的提案，从而导致多中心临床试验。它关注的是农村病人的特殊需求。我们特别感兴趣的是测试有希望的治疗方法，以增加中风后的恢复；因为这样的治疗可能会对公众健康产生很大的影响。

DESCRIPTION (provided by applicant): The University of lowa (Ul) Statewide Stroke Research Network meets the goal of the NINDS Stroke Trials Network of maximizing efficiencies in developing, promoting, and conducting high quality multi-site clinical trials on stroke prevention, treatment, and recovery. The current proposal builds on the rich tradition of the Ul as a leader in both developing and conducting NINDS-sponsored research, as well as on the Ul's role as the hub of a new integrated health care network - The Ul Health Alliance. The long-term goals of this proposal are to improve the efficiency of conducting Phase I - III stroke trials and to ensure a robust pipeline of well-trained clinical investigators to lead such trials. he proposal's immediate goal is to establish an expanded statewide research network for conducting stroke trials that reaches underserved rural patients who currently are unable to participate in stroke trials due to geographical barriers and who are subject to disparities in health outcomes. The proposed University of lowa Regional Coordinating Center (UIRCC) represents a comprehensive and integrated infrastructure for conducting trials that brings together healthcare providers, hospital administrators, clinical and health service investigators, public health officials, and patient advocates. The UIRCC comprises a network that expands the research capabilities of the Ul to 12 trial-ready sites. Those hospitals will be supplied by a statewide infrastructure of spokes that will allow adequate representation in trials of those Americans first evaluated at critical access hospitals. The UIRCC will capitalize on prior work by the PI to improve recruitment of patients presenting to critical access hospitals and maximize geographic access of patients. The feasibility of this approach is supported by the ongoing research data sharing collaboration, and a strong institutional support from the statewide healthcare alliance. We have plans already in place to expand this statewide network model to Nebraska and to the Dakotas. The UIRCC will also develop innovative translational research proposals that will lead to multicenter clinical trials through the NINDS stroke network by bringing together clinicians, early stage (i.e., bench to bedside) translational investigators, clinical trialists, epidemiologists, biostatisticians, and geographers to develop proposals of new approaches to stroke treatment, recovery, and prevention that utilize innovative methods (e.g., adaptive and pragmatic trial designs), and that focuses on the special needs of rural patients. We are particularly interested in trials testing promising therapies to augment recovery after stroke; as such treatments may have a large public health impact.