The University of Iowa's Statewide Stroke Research Network

描述(由申请人提供)：爱荷华大学(Ul)全州卒中研究网络符合NINDS卒中试验网络的目标，即在开发、推广和进行关于卒中预防、治疗和恢复的高质量多点临床试验方面最大限度地提高效率。目前的提案建立在UL作为NINDS赞助的研究开发和实施的领导者的丰富传统基础上，以及UL作为一个新的综合医疗网络-UL健康联盟的枢纽的作用。这项建议的长期目标是提高进行I-III期中风试验的效率，并确保训练有素的临床研究人员的强大渠道来领导此类试验。该提案的直接目标是建立一个扩大的全州研究网络，用于进行中风试验，覆盖服务不足的农村患者，这些患者目前由于地理障碍而无法参与中风试验，而且他们的健康结果存在差异。拟议的爱荷华大学区域协调中心(UIRCC)代表着一个全面和综合的基础设施，用于进行试验，将医疗保健提供者、医院管理人员、临床和卫生服务调查人员、公共卫生官员和患者权益倡导者聚集在一起。UIRCC由一个网络组成，该网络将UL的研究能力扩展到12个准备试验的站点。这些医院将由全州范围的辐条基础设施提供，这将允许在那些首先在关键通道医院进行评估的美国人的试验中有足够的代表性。UIRCC将利用PI之前的工作，改善向关键通道医院提供的患者的招募，并最大限度地扩大患者的地理通道。这种方法的可行性得到了正在进行的研究数据共享合作的支持，以及全州医疗保健联盟的强有力的机构支持。我们已经制定了计划，将这种全州范围的网络模式扩展到内布拉斯加州和达科他州。UIRCC还将开发创新的转化研究建议，通过NINDS卒中网络导致多中心临床试验，将临床医生、早期(即从病床到床边)转化研究人员、临床试验专家、流行病学家、生物统计学家和地理学家聚集在一起，制定利用创新方法(例如，适应性和务实的试验设计)并关注农村患者特殊需求的中风治疗、康复和预防的新方法的建议。我们特别感兴趣的是测试有前景的治疗方法以促进中风后康复的试验；因为这种治疗可能会对公众健康产生重大影响。

DESCRIPTION (provided by applicant): The University of lowa (Ul) Statewide Stroke Research Network meets the goal of the NINDS Stroke Trials Network of maximizing efficiencies in developing, promoting, and conducting high quality multi-site clinical trials on stroke prevention, treatment, and recovery. The current proposal builds on the rich tradition of the Ul as a leader in both developing and conducting NINDS-sponsored research, as well as on the Ul's role as the hub of a new integrated health care network - The Ul Health Alliance. The long-term goals of this proposal are to improve the efficiency of conducting Phase I - III stroke trials and to ensure a robust pipeline of well-trained clinical investigators to lead such trials. he proposal's immediate goal is to establish an expanded statewide research network for conducting stroke trials that reaches underserved rural patients who currently are unable to participate in stroke trials due to geographical barriers and who are subject to disparities in health outcomes. The proposed University of lowa Regional Coordinating Center (UIRCC) represents a comprehensive and integrated infrastructure for conducting trials that brings together healthcare providers, hospital administrators, clinical and health service investigators, public health officials, and patient advocates. The UIRCC comprises a network that expands the research capabilities of the Ul to 12 trial-ready sites. Those hospitals will be supplied by a statewide infrastructure of spokes that will allow adequate representation in trials of those Americans first evaluated at critical access hospitals. The UIRCC will capitalize on prior work by the PI to improve recruitment of patients presenting to critical access hospitals and maximize geographic access of patients. The feasibility of this approach is supported by the ongoing research data sharing collaboration, and a strong institutional support from the statewide healthcare alliance. We have plans already in place to expand this statewide network model to Nebraska and to the Dakotas. The UIRCC will also develop innovative translational research proposals that will lead to multicenter clinical trials through the NINDS stroke network by bringing together clinicians, early stage (i.e., bench to bedside) translational investigators, clinical trialists, epidemiologists, biostatisticians, and geographers to develop proposals of new approaches to stroke treatment, recovery, and prevention that utilize innovative methods (e.g., adaptive and pragmatic trial designs), and that focuses on the special needs of rural patients. We are particularly interested in trials testing promising therapies to augment recovery after stroke; as such treatments may have a large public health impact.