Admin supplement for The University of Iowa's Regional Stroke Research Network

爱荷华大学区域中风研究网络的管理补充

• 批准号: 10847746
• 负责人: ENRIQUE Carlos LEIRA
• 金额: $ 9.64万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10847746
• 关键词: Address; Air; American; Assessment tool; Award; Caring; Cerebrovascular Disorders; Classification; Clinical; Clinical Trials; Community Hospitals; Conduct Clinical Trials; County; Dedications; Development; Disparity; Enrollment; Ethics; Exclusion; Funding; Geographic Locations; Geography; Goals; Grant; Hospitals; Informed Consent; Infrastructure; Institution; Interdisciplinary Study; Intervention; Iowa; Iowan; Leadership; Link; Medical; Medicine; Methodology; Midwestern United States; Mission; Modernization; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Native Americans; Outcome; Participant; Patient Recruitments; Patient-Focused Outcomes; Patients; Phase; Population; Positioning Attribute; Productivity; Protocols documentation; Recovery; Research; Research Infrastructure; Research Personnel; Resources; Rural; Site; Stroke; Stroke prevention; StrokeNet trials; Supplementation; Testing; Training; Trust; United States National Institutes of Health; Universities; Uric Acid; acute stroke; adjudication; cerebrovascular; college; effective intervention; endovascular thrombectomy; experience; geographic barrier; improved; industry partner; innovation; member; multidisciplinary; next generation; novel; pandemic disease; participant enrollment; patient population; pre-clinical assessment; preclinical study; recruit; residence; rural patients; rural underserved; stroke intervention; stroke therapy; stroke trials; success; therapy development; trial readiness; working group

Project Summary/Abstract The University of Iowa Regional Coordinating Stroke Center (UIRCC) is ideally positioned to develop, promote, and efficiently conduct high-quality, multi-site clinical trials on stroke prevention, treatment, and recovery, in line with the overarching goal of the NIH StrokeNet. The University of Iowa (UI) is the only academic medical institution and comprehensive stroke center in the state. The UI has led and participated in landmark clinical trials in cerebrovascular disease for over 50 years such as the Org 10172 in Acute Stroke Treatment (TOAST) study, the NIH Stroke Scale and the TOAST classification of stroke subtype. Over the past 10 years, the UI has served as the UIRCC, bringing together our tradition of multidisciplinary, cutting-edge, cerebrovascular research. We demonstrated our ability to recruit patients by becoming the top enroller in the first StrokeNet trial, DEFUSE-3, and attracting a diverse patient population from the Upper Midwest—a region that experiences unique geographic barriers for enrollment. The UIRCC is committed to mitigating this unacceptable disparity. We are committed to holistically expanding stroke care by increasing the number of stroke interventions that effectively improve patient outcomes, and by expanding the number of patients who can benefit from such interventions. We have a strong commitment to remain a productive member of StrokeNet. Our first aim is to further advance the UIRCC as an efficient and adaptive infrastructure to recruit patients from the Upper Midwest. The restructured UIRCC comprises eight trial-ready geographically linked hospitals that will efficiently conduct critical trials and provide access to patients living in 119 counties from seven states, 56% of whom reside in rural zip codes and traditionally have been excluded from trials due to geographic barriers. It also includes a significant underserved Native American population. Our second aim is to continue to develop innovative interventions to expand stroke care. We plan to reproduce our uric acid success story, the first cerebroprotectant to succeed through the NIH Stroke Preclinical Assessment Network (SPAN). Our group will now be leading the testing of uric acid through the new StrokeNet Thrombectomy Endovascular Platform (STEP). We will continue to build on our multidisciplinary research infrastructure, a diverse group of investigators and trainees. This includes the UI SPAN translational team, as well as clinical researchers and industry partners. This infrastructure will continue to leverage dedicated UI pilot funds to ignite the development of interventions, with an emphasis on those that are simple and therefore widely applicable to a geographically diverse groups of patients.

项目概要/摘要 爱荷华大学地区中风协调中心 (UIRCC) 地理位置优越， 开发、促进和有效地进行高质量、多中心的卒中临床试验 预防、治疗和康复，符合 NIH StrokeNet 的总体目标。这 爱荷华大学（UI）是唯一的学术医疗机构和综合性卒中中心 在该州。 UI领导并参与了脑血管领域具有里程碑意义的临床试验 超过 50 年的疾病治疗经验，例如急性中风治疗 (TOAST) 研究中的 Org 10172、 NIH 卒中量表和卒中亚型的 TOAST 分类。在过去的 10 年里， UI 一直担任 UIRCC，汇集了我们多学科、前沿、 脑血管研究。我们通过成为顶尖来展示我们招募患者的能力 首次 StrokeNet 试验 DEFUSE-3 的招募者，并吸引了来自不同国家的不同患者群体 中西部北部地区——该地区在入学方面存在独特的地理障碍。这 UIRCC 致力于缩小这种不可接受的差距。我们致力于全面 通过增加中风干预的数量来扩大中风护理，有效改善 患者的治疗结果，并通过扩大可以从中受益的患者数量 干预措施。我们坚定地致力于继续成为 StrokeNet 富有成效的成员。我们的 第一个目标是进一步推动 UIRCC 成为高效、适应性强的招募基础设施 来自中西部北部的患者。重组后的 UIRCC 包括八个已准备好试用的 地理上相连的医院将有效地进行关键试验并提供访问 居住在七个州 119 个县的患者，其中 56% 居住在农村邮政编码地区， 传统上，由于地理障碍而被排除在试验之外。它还包括一个 大量得不到充分服务的美洲原住民人口。我们的第二个目标是持续发展 扩大中风护理的创新干预措施。我们计划重现尿酸治疗的成功 故事，第一个成功通过 NIH 中风临床前评估的脑保护剂 网络（SPAN）。我们的团队现在将通过新的方法领导尿酸测试 StrokeNet 血栓切除血管内平台 (STEP)。我们将继续在我们的基础上继续发展 多学科研究基础设施、多元化的研究人员和实习生群体。这 包括 UI SPAN 翻译团队以及临床研究人员和行业合作伙伴。 该基础设施将继续利用专门的 UI 试点资金来推动 干预措施，重点是那些简单且因此广泛适用于某一领域的干预措施 地理上不同的患者群体。