Admin supplement for The University of Iowa's Regional Stroke Research Network

爱荷华大学区域中风研究网络的管理补充

• 批准号: 10847746
• 负责人: ENRIQUE Carlos LEIRA
• 金额: $ 9.64万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10847746
• 关键词: Address; Air; American; Assessment tool; Award; Caring; Cerebrovascular Disorders; Classification; Clinical; Clinical Trials; Community Hospitals; Conduct Clinical Trials; County; Dedications; Development; Disparity; Enrollment; Ethics; Exclusion; Funding; Geographic Locations; Geography; Goals; Grant; Hospitals; Informed Consent; Infrastructure; Institution; Interdisciplinary Study; Intervention; Iowa; Iowan; Leadership; Link; Medical; Medicine; Methodology; Midwestern United States; Mission; Modernization; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Native Americans; Outcome; Participant; Patient Recruitments; Patient-Focused Outcomes; Patients; Phase; Population; Positioning Attribute; Productivity; Protocols documentation; Recovery; Research; Research Infrastructure; Research Personnel; Resources; Rural; Site; Stroke; Stroke prevention; StrokeNet trials; Supplementation; Testing; Training; Trust; United States National Institutes of Health; Universities; Uric Acid; acute stroke; adjudication; cerebrovascular; college; effective intervention; endovascular thrombectomy; experience; geographic barrier; improved; industry partner; innovation; member; multidisciplinary; next generation; novel; pandemic disease; participant enrollment; patient population; pre-clinical assessment; preclinical study; recruit; residence; rural patients; rural underserved; stroke intervention; stroke therapy; stroke trials; success; therapy development; trial readiness; working group

Project Summary/Abstract The University of Iowa Regional Coordinating Stroke Center (UIRCC) is ideally positioned to develop, promote, and efficiently conduct high-quality, multi-site clinical trials on stroke prevention, treatment, and recovery, in line with the overarching goal of the NIH StrokeNet. The University of Iowa (UI) is the only academic medical institution and comprehensive stroke center in the state. The UI has led and participated in landmark clinical trials in cerebrovascular disease for over 50 years such as the Org 10172 in Acute Stroke Treatment (TOAST) study, the NIH Stroke Scale and the TOAST classification of stroke subtype. Over the past 10 years, the UI has served as the UIRCC, bringing together our tradition of multidisciplinary, cutting-edge, cerebrovascular research. We demonstrated our ability to recruit patients by becoming the top enroller in the first StrokeNet trial, DEFUSE-3, and attracting a diverse patient population from the Upper Midwest—a region that experiences unique geographic barriers for enrollment. The UIRCC is committed to mitigating this unacceptable disparity. We are committed to holistically expanding stroke care by increasing the number of stroke interventions that effectively improve patient outcomes, and by expanding the number of patients who can benefit from such interventions. We have a strong commitment to remain a productive member of StrokeNet. Our first aim is to further advance the UIRCC as an efficient and adaptive infrastructure to recruit patients from the Upper Midwest. The restructured UIRCC comprises eight trial-ready geographically linked hospitals that will efficiently conduct critical trials and provide access to patients living in 119 counties from seven states, 56% of whom reside in rural zip codes and traditionally have been excluded from trials due to geographic barriers. It also includes a significant underserved Native American population. Our second aim is to continue to develop innovative interventions to expand stroke care. We plan to reproduce our uric acid success story, the first cerebroprotectant to succeed through the NIH Stroke Preclinical Assessment Network (SPAN). Our group will now be leading the testing of uric acid through the new StrokeNet Thrombectomy Endovascular Platform (STEP). We will continue to build on our multidisciplinary research infrastructure, a diverse group of investigators and trainees. This includes the UI SPAN translational team, as well as clinical researchers and industry partners. This infrastructure will continue to leverage dedicated UI pilot funds to ignite the development of interventions, with an emphasis on those that are simple and therefore widely applicable to a geographically diverse groups of patients.

项目摘要/摘要 爱荷华大学地区协调中风中心（UIRCC）的位置是 开发，促进并有效地进行中风的高质量的多站点临床试验 预防，治疗和恢复符合NIH Strokenet的总体目标。这 爱荷华大学（UI）是唯一的学术医疗机构和全面的中风中心 在州。 UI领导并参加了脑血管中的具有里程碑意义的临床试验 疾病已有50多年了，例如急性中风治疗（Toast）研究的ORG 10172， NIH中风量表和中风子类型的吐司分类。在过去的十年中， UI曾担任UIRCC，将我们的多学科，尖端的传统融合在一起 脑血管研究。我们证明了我们通过成为最高的招募患者的能力 参加第一次Strokenet试验的注册者Duduse-3，并吸引了潜水员的患者群体 上西部地区 - 一个地区，具有独特的地理障碍。 UIRCC致力于减轻这种不可接受的差异。我们致力于整体 通过增加有效改善的中风干预措施的数量来扩大中风护理 患者的结果，以及扩大可以从中受益的患者数量 干预措施。我们坚定地承诺成为Strotenet的富有成效成员。我们的 第一个目的是进一步推进UIRCC作为招聘的高效和适应性基础设施 中西部上部的患者。恢复的UIRCC包括八个试用 地理联系医院，将有效进行重大试验并提供接触 居住在119个县的七个州的患者，其中56％居住在农村邮政编码中， 传统上，由于地理障碍而被排除在试验之外。它还包括一个 服务不足的美国原住民。我们的第二个目标是继续发展 创新的干预措施以扩大中风护理。我们计划再现尿酸成功 故事，第一个通过NIH中风临床前评估成功的大脑保护剂 网络（跨度）。我们的小组现在将通过新的领导尿酸的测试 Strokenet血栓切除术血管内平台（步骤）。我们将继续以我们的 多学科研究基础设施，一个研究人员和受训者的潜水员群体。这 包括UI SPAN转化团队，以及临床研究人员和行业合作伙伴。 该基础设施将继续利用专用的UI飞行员资金来点燃 干预措施，重点是简单，因此广泛适用于 地理上不同的患者组。