Third Coast HIV-Related Cardiovascular and Sleep Disorders K12 Career Development Program

第三海岸 HIV 相关心血管和睡眠障碍 K12 职业发展计划

• 批准号: 10216328
• 负责人: Hossein Ardehali
• 金额: $ 40.82万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216328
• 关键词: Acquired Immunodeficiency Syndrome; Active Learning; Affect; Area; Cardiovascular Diseases; Chicago; Circadian Dysregulation; Clinical Sciences; Collaborations; Complex; Computer Models; Coronary artery; Custom; Data Science; Development; Diagnosis; Discipline; Educational Curriculum; Ensure; Epigenetic Process; Faculty; Foundations; Funding; Genomics; Growth; HIV; Heart failure; Individual; Infrastructure; Mentors; Mentorship; Methodology; Methods; Molecular; Monitor; National Heart, Lung, and Blood Institute; Pathway interactions; Persons; Physicians; Productivity; Program Development; Proteomics; Research; Research Personnel; Research Priority; Research Support; Resources; Risk; SECTM1 gene; Scholarship; Scientist; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Stress; Training; Training Programs; Training Support; United States; United States National Institutes of Health; Universities; Vascular Diseases; Vulnerable Populations; antiretroviral therapy; career; career development; cohort; community based research; disorder prevention; insight; next generation; programs; skills

PROGRAM SUMMARY/ABSTRACT The Third Coast HIV-related Cardiovascular and Sleep Disorders K12 Career Development Program (TC- CSK12) is a collaboration between the University of Chicago and Northwestern University that will establish an interdisciplinary pathway to academic productivity for the next generation of physician and non-physician junior faculty scientists. Mentored by world-class experts, tailored and individualized curricula most relevant to productivity provided by both program mentors and resource faculty will support trainees' projects in two high priority research topic areas in HIV-related – cardiovascular disease and sleep disorders. These two areas will be further stratified into one of four high impact pathways: heart failure; coronary artery and other vascular disease; sleep disordered breathing; and circadian disruption and stress. Trainees' mentored research will be foundational for career-long intellectual growth and academic advancement, and will be supported by resources for collaborative scholarship and discovery across a range of scientific disciplines, methods and concepts. TC-CSK12 will also have scientific disciplinary clusters: molecular and cellular; genomics, epigenetics and proteomics clinical and translational; and data science and computational modeling. Didactic and experiential learning across these clusters will be customized with mentoring for each individual trainee's pathway. The research itself, along with mentoring and cross-disciplinary curricula, will enable new insights into the complex mechanisms underlying HIV related cardiovascular and sleep disorders (HIV-CS) and careers that will produce major advances in diagnosis, treatment, monitoring and/or prevention of the disorders targeted in our pathways. The ultimate objective of our program is to identify, inspire, and support development of independent, NHLBI-funded investigators in HIV research with strong and broad methodological and conceptual skills as well as collaboration expertise/enthusiasm. Training, mentorship and career development strategies will draw upon several successful programs many of which are already shared across NU and UC and set a strong precedent for TC-CSK12: the integrated Third Coast Center for AIDS Research, two successful and collaborative CTSAs, and other successful K12 and NIH-funded training programs at the University of Chicago and Northwestern University including a collaboratively held T32 in sleep for the past 20 years. In addition to collaboration-building infrastructure that brings faculty into the study and mentorship of HIV-CS. Trainees and their mentors will draw on our diverse NIH-funded, community-based research cohorts of HIV-infected, -affected, and at-risk persons in one of the largest domestic HIV epicenters in the United States. This ensures that research and training supported by this program will positively impact the most vulnerable populations in years to come as we move towards elimination of both HIV and its complications not yet solved by antiretroviral therapy (ART).

程序摘要/摘要 第三海岸HIV相关的心血管和睡眠障碍K12职业发展计划（TC- CSK12）是芝加哥大学和西北大学之间的合作 为下一代身体和 非医师初级教师科学家。由世界一流的专家指导，量身定制和个性化 课程与计划导师和资源教师提供的生产率最相关的课程将支持 受训者在两个高优先研究主题领域的项目与HIV有关的领域 - 心血管疾病和 睡眠障碍。这两个区域将进一步分为四个高冲击途径之一：心脏 失败;冠状动脉和其他血管疾病；睡眠不足的呼吸；和昼夜节律的破坏 和压力。学员的修改研究将是职业生涯长期智力增长的基础 学术进步，并将得到合作科学与发现的资源的支持 在一系列科学学科，方法和概念上。 TC-CSK12也将具有科学 纪律群：分子和细胞；基因组学，表观遗传学和蛋白质组学临床和 翻译；以及数据科学和计算建模。教学和经验丰富的学习 这些集群将通过为每个学员的道路进行心理定制。研究本身， 除了心理和跨学科课程，还将为综合体提供新的见解 与HIV相关的心血管和睡眠障碍（HIV-CS）和职业的机制 在诊断，治疗，监测和/或预防针对性疾病的诊断，治疗，监测和/或 我们的道路。我们计划的最终目标是识别，启发和支持的发展 独立的NHLBI资助的HIV研究研究人员，具有强大而广泛的方法论， 概念技能以及协作专业知识/热情。培训，精通职业和职业 开发策略将借鉴几个成功的计划，其中许多已经共享 跨NU和UC，为TC-CSK12树立了强烈的先例：综合的第三海岸艾滋病中心 研究，两个成功和协作的CTSA，以及其他成功的K12和NIH资助的培训 芝加哥大学和西北大学的计划 在过去的20年中睡觉。除了合作建设基础设施，还将教师带入 HIV-CS的研究和心态。学员及其心态将借鉴我们的潜水员NIH资助， 最大的艾滋病毒感染，受艾滋病毒感染，受艾滋病毒影响和高危人群的研究 美国国内艾滋病毒中心。这样可以确保由此支持的研究和培训 随着我们迈向的几年，计划将对最脆弱的人口产生积极影响 消除艾滋病毒及其并发症尚未通过抗逆转录病毒疗法（ART）解决。