Third Coast HIV-Related Cardiovascular and Sleep Disorders K12 Career Development Program

数据摘要/摘要 第三海岸艾滋病毒相关的心血管和睡眠障碍K12职业发展计划（TC- CSK 12）是芝加哥大学和西北大学之间的合作项目， 为下一代医生建立跨学科的学术生产力途径， 非医生的初级科学家。由世界级专家指导，量身定制，个性化 由项目导师和资源教师提供的与生产力最相关的课程将支持 在艾滋病毒相关的心血管疾病和 睡眠障碍这两个领域将进一步分为四个高影响力途径之一：心脏 衰竭;冠状动脉和其他血管疾病;睡眠呼吸障碍;和昼夜节律紊乱 和压力学员的指导研究将是职业生涯长期智力增长的基础， 学术进步，并将通过合作奖学金和发现资源的支持 跨越一系列科学学科、方法和概念。TC-CSK 12还将具有科学的 学科集群：分子和细胞;基因组学，表观遗传学和蛋白质组学临床和 翻译;数据科学和计算建模。教学和体验式学习 这些小组将根据每个学员的学习途径进行个性化的指导。研究本身， 沿着指导和跨学科课程，将使新的见解复杂 艾滋病毒相关的心血管和睡眠障碍（HIV-CS）的潜在机制和职业， 在诊断、治疗、监测和/或预防目标疾病方面取得重大进展， 我们的道路。我们计划的最终目标是识别，激励和支持发展 独立的，NHLBI资助的艾滋病毒研究调查人员，具有强大和广泛的方法， 概念技能以及协作专业知识/热情。培训、辅导和职业 发展战略将借鉴几个成功的计划，其中许多已经分享 在NU和UC之间，并为TC-CSK 12树立了一个强有力的先例：综合第三海岸艾滋病中心 研究，两个成功的合作CTSA，以及其他成功的K12和NIH资助的培训 项目在芝加哥和西北大学的大学，包括合作举行的T32， 睡了20年。除了合作建设基础设施，使教师进入 研究和指导艾滋病毒感染者。学员和他们的导师将利用我们多样化的NIH资助， 艾滋病毒感染者、受影响者和高危人群的社区研究队列， 美国国内的艾滋病中心。这确保了由其支持的研究和培训 该计划将在未来几年对最弱势群体产生积极影响， 消除艾滋病毒及其尚未通过抗逆转录病毒疗法解决的并发症。

PROGRAM SUMMARY/ABSTRACT The Third Coast HIV-related Cardiovascular and Sleep Disorders K12 Career Development Program (TC- CSK12) is a collaboration between the University of Chicago and Northwestern University that will establish an interdisciplinary pathway to academic productivity for the next generation of physician and non-physician junior faculty scientists. Mentored by world-class experts, tailored and individualized curricula most relevant to productivity provided by both program mentors and resource faculty will support trainees' projects in two high priority research topic areas in HIV-related – cardiovascular disease and sleep disorders. These two areas will be further stratified into one of four high impact pathways: heart failure; coronary artery and other vascular disease; sleep disordered breathing; and circadian disruption and stress. Trainees' mentored research will be foundational for career-long intellectual growth and academic advancement, and will be supported by resources for collaborative scholarship and discovery across a range of scientific disciplines, methods and concepts. TC-CSK12 will also have scientific disciplinary clusters: molecular and cellular; genomics, epigenetics and proteomics clinical and translational; and data science and computational modeling. Didactic and experiential learning across these clusters will be customized with mentoring for each individual trainee's pathway. The research itself, along with mentoring and cross-disciplinary curricula, will enable new insights into the complex mechanisms underlying HIV related cardiovascular and sleep disorders (HIV-CS) and careers that will produce major advances in diagnosis, treatment, monitoring and/or prevention of the disorders targeted in our pathways. The ultimate objective of our program is to identify, inspire, and support development of independent, NHLBI-funded investigators in HIV research with strong and broad methodological and conceptual skills as well as collaboration expertise/enthusiasm. Training, mentorship and career development strategies will draw upon several successful programs many of which are already shared across NU and UC and set a strong precedent for TC-CSK12: the integrated Third Coast Center for AIDS Research, two successful and collaborative CTSAs, and other successful K12 and NIH-funded training programs at the University of Chicago and Northwestern University including a collaboratively held T32 in sleep for the past 20 years. In addition to collaboration-building infrastructure that brings faculty into the study and mentorship of HIV-CS. Trainees and their mentors will draw on our diverse NIH-funded, community-based research cohorts of HIV-infected, -affected, and at-risk persons in one of the largest domestic HIV epicenters in the United States. This ensures that research and training supported by this program will positively impact the most vulnerable populations in years to come as we move towards elimination of both HIV and its complications not yet solved by antiretroviral therapy (ART).