Third Coast HIV-Related Cardiovascular and Sleep Disorders K12 Career Development Program

第三海岸 HIV 相关心血管和睡眠障碍 K12 职业发展计划

• 批准号: 10432041
• 负责人: Hossein Ardehali
• 金额: $ 30万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10432041
• 关键词: Acquired Immunodeficiency Syndrome; Active Learning; Affect; Area; Cardiovascular Diseases; Chicago; Circadian Dysregulation; Clinical Sciences; Collaborations; Complex; Computer Models; Coronary artery; Custom; Data Science; Development; Diagnosis; Discipline; Educational Curriculum; Ensure; Epigenetic Process; Faculty; Foundations; Funding; Genomics; Growth; HIV; Heart failure; Individual; Infrastructure; Mentors; Mentorship; Methodology; Methods; Molecular; Monitor; National Heart, Lung, and Blood Institute; Pathway interactions; Persons; Physicians; Productivity; Program Development; Proteomics; Research; Research Personnel; Research Priority; Research Support; Resources; Risk; SECTM1 gene; Scholarship; Scientist; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Stress; Training; Training Programs; Training Support; United States; United States National Institutes of Health; Universities; Vascular Diseases; Vulnerable Populations; antiretroviral therapy; career; career development; cohort; community based research; disorder prevention; insight; next generation; programs; skills

PROGRAM SUMMARY/ABSTRACT The Third Coast HIV-related Cardiovascular and Sleep Disorders K12 Career Development Program (TC- CSK12) is a collaboration between the University of Chicago and Northwestern University that will establish an interdisciplinary pathway to academic productivity for the next generation of physician and non-physician junior faculty scientists. Mentored by world-class experts, tailored and individualized curricula most relevant to productivity provided by both program mentors and resource faculty will support trainees' projects in two high priority research topic areas in HIV-related – cardiovascular disease and sleep disorders. These two areas will be further stratified into one of four high impact pathways: heart failure; coronary artery and other vascular disease; sleep disordered breathing; and circadian disruption and stress. Trainees' mentored research will be foundational for career-long intellectual growth and academic advancement, and will be supported by resources for collaborative scholarship and discovery across a range of scientific disciplines, methods and concepts. TC-CSK12 will also have scientific disciplinary clusters: molecular and cellular; genomics, epigenetics and proteomics clinical and translational; and data science and computational modeling. Didactic and experiential learning across these clusters will be customized with mentoring for each individual trainee's pathway. The research itself, along with mentoring and cross-disciplinary curricula, will enable new insights into the complex mechanisms underlying HIV related cardiovascular and sleep disorders (HIV-CS) and careers that will produce major advances in diagnosis, treatment, monitoring and/or prevention of the disorders targeted in our pathways. The ultimate objective of our program is to identify, inspire, and support development of independent, NHLBI-funded investigators in HIV research with strong and broad methodological and conceptual skills as well as collaboration expertise/enthusiasm. Training, mentorship and career development strategies will draw upon several successful programs many of which are already shared across NU and UC and set a strong precedent for TC-CSK12: the integrated Third Coast Center for AIDS Research, two successful and collaborative CTSAs, and other successful K12 and NIH-funded training programs at the University of Chicago and Northwestern University including a collaboratively held T32 in sleep for the past 20 years. In addition to collaboration-building infrastructure that brings faculty into the study and mentorship of HIV-CS. Trainees and their mentors will draw on our diverse NIH-funded, community-based research cohorts of HIV-infected, -affected, and at-risk persons in one of the largest domestic HIV epicenters in the United States. This ensures that research and training supported by this program will positively impact the most vulnerable populations in years to come as we move towards elimination of both HIV and its complications not yet solved by antiretroviral therapy (ART).

程序总结/文摘

项目成果

Bi Us, For Us: Articulating foundational principles for research in partnership with bisexual communities.

• DOI: 10.1080/15299716.2020.1841478
• 发表时间: 2020
• 期刊: Journal of bisexuality
• 影响因子: 1.7
• 作者: Beach LB;Hall CDX
• 通讯作者: Hall CDX

Bisexual people's utilization of sexual health services at an LGBTQ Community Center in Chicago.

• DOI: 10.1080/15299716.2020.1825270
• 发表时间: 2020
• 期刊: Journal of bisexuality
• 影响因子: 1.7
• 作者: Holmes N;Beach L
• 通讯作者: Beach L

NERO: a biomedical named-entity (recognition) ontology with a large, annotated corpus reveals meaningful associations through text embedding.

• DOI: 10.1038/s41540-021-00200-x
• 发表时间: 2021-10-20
• 期刊: NPJ systems biology and applications
• 影响因子: 4
• 作者: Wang K;Stevens R;Alachram H;Li Y;Soldatova L;King R;Ananiadou S;Schoene AM;Li M;Christopoulou F;Ambite JL;Matthew J;Garg S;Hermjakob U;Marcu D;Sheng E;Beißbarth T;Wingender E;Galstyan A;Gao X;Chambers B;Pan W;Khomtchouk BB;Evans JA;Rzhetsky A
• 通讯作者: Rzhetsky A

Targeting the cytoskeleton and extracellular matrix in cardiovascular disease drug discovery.

• DOI: 10.1080/17460441.2022.2047645
• 发表时间: 2022-05
• 期刊: EXPERT OPINION ON DRUG DISCOVERY
• 影响因子: 6.3
• 作者: Khomtchouk, Bohdan B.;Lee, Yoon Seo;Khan, Maha L.;Sun, Patrick;Mero, Deniel;Davidson, Michael H.
• 通讯作者: Davidson, Michael H.

Reducing the use of empiric antibiotic therapy in COVID-19 on hospital admission.

• DOI: 10.1186/s12879-021-06219-z
• 发表时间: 2021-06-02
• 期刊: BMC infectious diseases
• 影响因子: 3.7
• 作者: Pettit NN;Nguyen CT;Lew AK;Bhagat PH;Nelson A;Olson G;Ridgway JP;Pho MT;Pagkas-Bather J
• 通讯作者: Pagkas-Bather J