Third Coast HIV-Related Cardiovascular and Sleep Disorders K12 Career Development Program

第三海岸 HIV 相关心血管和睡眠障碍 K12 职业发展计划

• 批准号: 9761573
• 负责人: Hossein Ardehali
• 金额: $ 31.71万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761573
• 关键词: Acquired Immunodeficiency Syndrome; Active Learning; Affect; Area; Cardiovascular Diseases; Chicago; Circadian Dysregulation; Clinical Sciences; Collaborations; Complex; Computer Simulation; Coronary artery; Custom; Data Science; Development; Diagnosis; Discipline; Educational Curriculum; Ensure; Epigenetic Process; Faculty; Foundations; Funding; Genomics; Growth; HIV; Heart failure; Individual; Infrastructure; Mentors; Mentorship; Methodology; Methods; Molecular; Monitor; National Heart, Lung, and Blood Institute; Pathway interactions; Persons; Physicians; Productivity; Program Development; Proteomics; Research; Research Personnel; Research Priority; Research Support; Resources; Risk; SECTM1 gene; Scholarship; Scientist; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Stress; Training; Training Programs; Training Support; United States; United States National Institutes of Health; Universities; Vascular Diseases; Vulnerable Populations; antiretroviral therapy; career; career development; cohort; community based participatory research; disorder prevention; insight; next generation; programs; skills

PROGRAM SUMMARY/ABSTRACT The Third Coast HIV-related Cardiovascular and Sleep Disorders K12 Career Development Program (TC- CSK12) is a collaboration between the University of Chicago and Northwestern University that will establish an interdisciplinary pathway to academic productivity for the next generation of physician and non-physician junior faculty scientists. Mentored by world-class experts, tailored and individualized curricula most relevant to productivity provided by both program mentors and resource faculty will support trainees' projects in two high priority research topic areas in HIV-related – cardiovascular disease and sleep disorders. These two areas will be further stratified into one of four high impact pathways: heart failure; coronary artery and other vascular disease; sleep disordered breathing; and circadian disruption and stress. Trainees' mentored research will be foundational for career-long intellectual growth and academic advancement, and will be supported by resources for collaborative scholarship and discovery across a range of scientific disciplines, methods and concepts. TC-CSK12 will also have scientific disciplinary clusters: molecular and cellular; genomics, epigenetics and proteomics clinical and translational; and data science and computational modeling. Didactic and experiential learning across these clusters will be customized with mentoring for each individual trainee's pathway. The research itself, along with mentoring and cross-disciplinary curricula, will enable new insights into the complex mechanisms underlying HIV related cardiovascular and sleep disorders (HIV-CS) and careers that will produce major advances in diagnosis, treatment, monitoring and/or prevention of the disorders targeted in our pathways. The ultimate objective of our program is to identify, inspire, and support development of independent, NHLBI-funded investigators in HIV research with strong and broad methodological and conceptual skills as well as collaboration expertise/enthusiasm. Training, mentorship and career development strategies will draw upon several successful programs many of which are already shared across NU and UC and set a strong precedent for TC-CSK12: the integrated Third Coast Center for AIDS Research, two successful and collaborative CTSAs, and other successful K12 and NIH-funded training programs at the University of Chicago and Northwestern University including a collaboratively held T32 in sleep for the past 20 years. In addition to collaboration-building infrastructure that brings faculty into the study and mentorship of HIV-CS. Trainees and their mentors will draw on our diverse NIH-funded, community-based research cohorts of HIV-infected, -affected, and at-risk persons in one of the largest domestic HIV epicenters in the United States. This ensures that research and training supported by this program will positively impact the most vulnerable populations in years to come as we move towards elimination of both HIV and its complications not yet solved by antiretroviral therapy (ART).

节目摘要/摘要 第三海岸艾滋病毒相关心血管和睡眠障碍K12职业发展计划(TC- CSK12)是芝加哥大学和西北大学的合作项目，将 为下一代医生和 非内科初级教员科学家。由世界级专家指导，量身定做，个性化 由计划导师和资源教师提供的与生产效率最相关的课程将支持 受训人员在艾滋病毒相关心血管疾病和艾滋病毒相关心血管疾病两个高度优先研究主题领域的项目 睡眠障碍。这两个区域将进一步划分为四个高影响路径之一：心脏 心力衰竭；冠状动脉和其他血管疾病；睡眠呼吸紊乱；以及昼夜节律紊乱 和压力。学员的指导性研究将为职业生涯中的智力成长和 学术进步，并将得到合作学术和发现资源的支持 涉及一系列科学学科、方法和概念。TC-CSK12也将拥有科学 学科群：分子和细胞；基因组学、表观遗传学和蛋白质组学临床和 翻译；以及数据科学和计算建模。教学和体验式学习相结合 这些集群将通过针对每个受训学员的路径进行指导来定制。研究本身， 与指导和跨学科课程一起，将使人们能够对该综合体有新的见解 HIV相关心血管和睡眠障碍(HIV-CS)的发病机制和职业 在诊断、治疗、监测和/或预防#年目标疾病方面取得重大进展 我们的道路。我们计划的最终目标是确定、激励和支持 在艾滋病毒研究中由NHLBI资助的独立调查人员具有强大而广泛的方法论和 概念技能以及协作专业知识/热情。培训、指导和职业生涯 发展战略将借鉴几个成功的项目，其中许多项目已经共享 并为TC-CSK12开创了一个强有力的先例：综合第三海岸艾滋病中心 研究，两个成功和协作的CTSA，以及其他成功的K12和NIH资助的培训 芝加哥大学和西北大学的项目包括在 在过去的20年里一直在睡觉。除了协作构建基础设施之外，还可以将教师带入 对HIV-CS的研究和指导。学员和他们的导师将利用我们由NIH资助的多样化的， 艾滋病病毒感染者、感染者和高危人群的社区研究队列是最大的研究之一 美国国内的艾滋病毒中心。这确保了由该组织支持的研究和培训 该计划将在未来几年对最脆弱的人群产生积极影响，因为我们正在 消除艾滋病毒及其尚未通过抗逆转录病毒疗法(ART)解决的并发症。