Administrative Core

行政核心支持这个跨学科和多大学的调查团队。P01 该计划有三个执行地点：南加州大学大学公园校园（核心C，项目3）;南加州大学健康 科学校园（核心B，项目1和4）和加州大学圣地亚哥分校（项目2）。拟议 该计划包括一组具有AD神经生物学专业知识的合作科学家， 群体神经影像学，小鼠脑影像学，脑血管生物学，临床神经学，认知 神经科学，神经心理学，AD流行病学，大规模空气污染建模，环境 流行病学、吸入接触评估和神经毒理学。 行政核心的具体目标是： 1)提供综合项目领导和协调; (2)加强现有的伙伴关系，促进新的合作，并促进初级 南加州大学和参与机构的研究人员/学员; (3)通过每月的联合小组会议评估该计划的科学进展， 每季度召开一次会议，每年召开一次项目核心领导人和关键人员与外部 咨询委员会; (4)提供财政管理和行政服务，监测资源和支出; (5)向更广泛的科学界联合传播研究成果。 行政核心将提供领导、监督、规划和协调， 跨项目的科学整合和综合，促进跨学科的互动，并支持多学科 拟议方案活动的现场运作。拟议的P01的协作基础设施是 AirPollBrain（PI：Finch & Chen）是一个由南加州大学自2010年以来资助的合作网络。来 在过去的几年里，AirPollBrain已经与南加州大学的几个脑科学中心/研究所建立了合作关系 科学（例如，ADRC/记忆和衰老中心，Zilkha神经遗传研究所，马克和玛丽史蒂文斯 神经影像学和信息学研究所;发展思维研究所），并帮助创建了新的研究 南加州最近更新的环境暴露对神经系统影响计划 环境健康科学中心（P30 ES 007048 -20）。行政核心处于有利地位， 利用这些机构资源，最大限度地发挥拟议的P01研究的影响。

The Administrative Core supports this interdisciplinary and multi-university team of investigators. The P01 program has three performance sites: the USC University Park Campus (Core C, Projects 3); USC Health Science Campus (Core B, Projects 1 & 4); and University of California, San Diego (Project 2). The proposed program includes an established group of collaborative scientists with expertise in neurobiology of AD, population neuroimaging, mouse brain imaging, brain vascular biology, clinical neurology, cognitive neurosciences, neuropsychology, epidemiology of AD, large-scale air pollution modeling, environmental epidemiology, inhalation exposure assessment and neurotoxicology. The specific aims of the Administrative Core are: 1) Provide the integrated program leadership and coordination; (2) Strengthen existing partnerships, facilitate new collaborations and foster the career development of junior investigators/trainees across USC and participating institutes; (3) Assess scientific progress of the program, through joint group meetings per month, work-in-progress meetings per quarter, and annual meetings of the project-core leaders and key personnel with the External Advisory Committee; (4) Provide fiscal management and administrative services and monitor resources and expenditures; (5) Carry out the joint dissemination of study results to the broader scientific community. The Administrative Core will provide leadership, oversight, planning, and coordination to facilitate scientific integration and synthesis across projects, promote cross-disciplinary interactions, and support multi- site operation of proposed program activities. The collaborative infrastructure of the proposed P01 is the product of the AirPollBrain (PIs: Finch & Chen), a collaborative network funded by USC since 2010. Over the last few years, the AirPollBrain has developed partnerships with several USC-based Centers/Institutes in brain sciences (e.g., ADRC/Memory and Aging Center, Zilkha Neurogenetic Institute, Mark and Mary Stevens Neuroimaging and Informatics Institute; Institute of Developing Mind) and also helped create the new Research Program on Neurological Effects of Environmental Exposure for the latest renewal of Southern California Environmental Health Sciences Center (P30 ES007048-20). The Administrative Core is well positioned to leverage these institutional resources and maximize the impact of the proposed P01 research.