Brain atrophy, cognitive impairment and Alzheimer's in low CVD-risk population

低心血管疾病风险人群中的脑萎缩、认知障碍和阿尔茨海默病

• 批准号: 10203685
• 负责人: CALEB E FINCH
• 金额: $ 103.59万
• 依托单位: CHAPMAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10203685
• 关键词: 2019-nCoV; Administrative Supplement; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Bolivia; Bolivian; COVID-19; COVID-19 pandemic; Cardiovascular Diseases; Cognitive; Data; Dementia; Diet; Disease; Elderly; Epidemic; Funding; Genotype; Goals; Impaired cognition; Impairment; Incidence; Indigenous; Individual; Infection; Inflammation; Light; Longevity; Low Prevalence; Morbidity - disease rate; Neurologic; Parents; Phase; Physical activity; Population; Prevalence; Research; Risk; Virus Diseases; cardiovascular disorder risk; cerebral atrophy; cognitive function; cognitive testing; dementia risk; infection burden; inflammatory marker; mortality; neuroimaging

Project Summary The parent RF1 (1 RF1 AG054442-01) provides new data on brain atrophy and Alzheimer’s disease and Related Dementias (ADRD) in two indigenous Bolivian populations, the Tsimane and the Moseten, with extremely low rates of cardiovascular disease (CVD) but high burdens of infection and inflammation. The aims of this project are: (1) Longitudinal assessment of cognitive impairment and dementia in a low cardiovascular disease (CVD) risk population, Tsimane forager-horticulturalists of lowland Bolivia; (2) Neuroimaging to identify brain atrophy correlates of cognitive impairment, AD and other dementias; (3) Characterization of the prevalence of brain atrophy, cognitive impairment, and dementias in the Tsimane; (4) Collect in- depth data on diet and physical activity; and (5) Examine the interaction of inflammation and APOE genotype on cognitive functioning for individual longitudinal change. ADRD prevalence was estimated during the first 2.5 years of NIA funding. Current results indicate a low prevalence (<5%) of dementia after age 70 with no cases of moderate to severe dementia. The two specific aims of this administrative supplement will determine: (1) whether cognitive impairment and dementia are risk factors for SARS-CoV-2 infection and/or morbidity and mortality, if infected; and (2) if Covid-19 results cognitive and neurological aging impairment. The first aim is necessary for interpreting existing data and achieving the original project goals. it is necessary to determine whether those who develop cognitive impairment dementia are at greater risk for COVID-19 mortality in order to control for a potential downward bias in the estimation of dementia incidence. The second aim presents a new unique opportunity to investigate the original project goal of studying impacts of infection on cognitive decline and ADRD. It will evaluate the impact of COVID-19 infection on cognitive function and ADRD incidence.

项目摘要 亲本RF1(1RF1 AG054442-01)提供了有关脑萎缩和阿尔茨海默氏症的新数据 玻利维亚两个土著群体齐曼人的疾病和相关痴呆症 而Moseten，心血管疾病(CVD)的发病率极低，但 感染和炎症。本项目的目标是：(1)纵向评估 低风险心血管疾病(CVD)人群中的认知障碍和痴呆 低地玻利维亚园艺家Tsimane Forager；(2)神经成像识别脑萎缩 认知损害与阿尔茨海默病和其他痴呆的相关性；(3) 大脑萎缩、认知障碍和痴呆的患病率；(4)收集- 关于饮食和体力活动的深度数据；以及(5)检查炎症和 载脂蛋白E基因对个体纵向变化认知功能的影响。ADRD流行率 估计是在国家投资局资助的头两年半期间。目前的结果表明， 70岁以后的痴呆症患病率(5%)，没有中到重度痴呆症的病例。这个 本行政副刊的两个具体目标将决定：(1)认知 功能障碍和痴呆是SARS-CoV-2感染和/或发病率的危险因素 如果感染，死亡率；以及(2)如果新冠肺炎导致认知和神经衰老损害。 第一个目标对于解释现有数据和实现最初的项目目标是必要的。 有必要确定那些患有认知障碍痴呆症的人是否处于 新冠肺炎死亡率的更大风险，以控制潜在的下行偏差 痴呆症发病率的估算。第二个目标提供了一个新的独特的机会 调查最初的项目目标，即研究感染对认知能力下降和 阿德勒。它将评估新冠肺炎感染对认知功能和不良反应的影响 发病率。

项目成果

Methodological differences cannot explain associations between health, anthropometrics, and excess resting metabolic rate.

方法学差异无法解释健康、人体测量学和过量静息代谢率之间的关联。

• DOI: 10.1002/ajpa.23811
• 发表时间: 2019
• 期刊: American journal of physical anthropology
• 影响因子: 2.8
• 作者: Gurven,Michael;Trumble,Benjamin;Stieglitz,Jonathan;Cummings,Dan;Kaplan,Hillard;Blackwell,AaronD;Yetish,Gandhi;Pontzer,Herman
• 通讯作者: Pontzer,Herman

Information transmission and the oral tradition: Evidence of a late-life service niche for Tsimane Amerindians.

信息传播和口头传统：提斯曼美洲印第安人晚年服务利基的证据。

• DOI: 10.1016/j.evolhumbehav.2017.10.006
• 发表时间: 2018
• 期刊: Evolution and human behavior : official journal of the Human Behavior and Evolution Society
• 作者: Schniter,Eric;Wilcox,NathanielT;Beheim,BretA;Kaplan,HillardS;Gurven,Michael
• 通讯作者: Gurven,Michael

Cultural variation in running techniques among non-industrial societies.

非工业社会中跑步技术的文化差异。

• DOI: 10.1017/ehs.2022.12
• 发表时间: 2022
• 期刊: Evolutionary human sciences
• 影响因子: 2.6
• 作者: Wallace,IanJ;Kraft,ThomasS;Venkataraman,VivekV;Davis,HelenE;Holowka,NicholasB;Harris,AlexandraR;Lieberman,DanielE;Gurven,Michael
• 通讯作者: Gurven,Michael

Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations.

• DOI: 10.1073/pnas.2207544120
• 发表时间: 2023-01-03
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.

• DOI: 10.1002/alz.12626
• 发表时间: 2023-01
• 期刊: ALZHEIMERS & DEMENTIA
• 影响因子: 14
• 作者: Gatz, Margaret;Mack, Wendy J.;Chui, Helena C.;Law, E. Meng;Barisano, Giuseppe;Sutherland, M. Linda;Sutherland, James D.;Rodriguez, Daniel Eid;Gutierrez, Raul Quispe;Adrian, Juan Copajira;Cuata, Jesus Bani;Borenstein, Amy R.;Walters, Ellen E.;Irimia, Andrei;Rowan, Christopher J.;Wann, L. Samuel;Allam, Adel H.;Thompson, Randall C.;Miyamoto, Michael, I;Michalik, David E.;Cummings, Daniel K.;Seabright, Edmond;Garcia, Angela R.;Hooper, Paul L.;Kraft, Thomas S.;Finch, Caleb E.;Thomas, Gregory S.;Stieglitz, Jonathan;Trumble, Benjamin C.;Gurven, Michael D.;Kaplan, Hillard
• 通讯作者: Kaplan, Hillard