Neural network underlying memory erasure

神经网络底层记忆擦除

• 批准号: DP150102496
• 负责人: Prof Jee Hyun Kim
• 金额: $ 24.5万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150102496
• 关键词: Neural; network; underlying; memory; erasure

Memory expression can easily be reduced through the process of extinction, which involves repeated presentations of cues involved in that memory but without any outcome. In adult animals (including humans), it is widely accepted that extinction leads to a temporary inhibition of the original memory that remains largely unaltered. Remarkably, extinction causes erasure in juvenile rodents so that the original memory is permanently reduced. This is because the normal maturational changes in the brain result in fundamental developmental differences in the neural network underlying extinction. This project aims to map out this network across life, and also to reproduce the juvenile network in adult rats to erase memories via extinction in adulthood.

记忆表达很容易通过消退过程而减少，消退过程涉及重复呈现与该记忆有关的线索，但没有任何结果。在成年动物（包括人类）中，人们普遍认为，灭绝会导致原始记忆暂时受到抑制，而原始记忆基本上没有改变。值得注意的是，灭绝会导致幼年啮齿动物的记忆被抹去，从而使原始记忆永久减少。这是因为大脑的正常成熟变化导致了导致灭绝的神经网络的根本发育差异。该项目旨在绘制整个生命过程中的这个网络，并在成年老鼠身上复制幼年网络，以通过成年后的灭绝来消除记忆。