Extinction of drug-seeking in adolescent rats

青春期大鼠寻药行为的消失

• 批准号: DE120100110
• 负责人: Prof Jee Hyun Kim
• 金额: $ 26.91万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-02-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE120100110
• 关键词: Extinction; drug; seeking; adolescent; rats

To investigate the ontogeny of drug abuse and its treatment, acquisition and treatment of drug-seeking behaviour will be examined in adolescent rats. I expect that adolescent rats will fail to inhibit drug-seeking behaviour, and show immaturity in cortical brain areas. Increasing cortical activity may rescue their ability to inhibit drug-seeking.

为了研究药物滥用及其治疗的个体发生，将在青春期大鼠中检查药物寻求行为的获得和治疗。我预计，青春期的老鼠将无法抑制药物寻求行为，并显示出大脑皮层区域的不成熟。增加皮质活动可能会挽救他们抑制药物寻找的能力。