Prefrontal dopamine in the dynamic processes of learning across lifetime

前额多巴胺在一生学习动态过程中的作用

• 批准号: FT220100351
• 负责人: Prof Jee Hyun Kim
• 金额: $ 72.97万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-06-10 至 2027-06-09
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100351
• 关键词: Prefrontal; dopamine; dynamic; processes; learning

To facilitate age-specific adaptive action in a changing environment, how we learn changes not only as we grow, but also as we age. However, the neurobiological processes in these age-related changes are poorly studied. This is a significant knowledge gap that needs to be addressed to promote healthy cognitive development and ageing. This research program aims to examine the contribution of prefrontal dopamine and its receptors D1 and D2 in associative learning and its inhibition at 9 distinct ages spanning development to ageing in male and female rats. The outcomes will provide a new neuroscientific framework to understand learning and memory throughout life, which will foster new research opportunities and inform our education and health.

为了在不断变化的环境中促进特定年龄的适应性行动，我们的学习方式不仅随着我们的成长而变化，而且随着我们的年龄而变化。然而，这些年龄相关变化的神经生物学过程研究甚少。这是一个重大的知识差距，需要加以解决，以促进健康的认知发展和老龄化。本研究旨在研究前额叶多巴胺及其受体D1和D2在雄性和雌性大鼠从发育到衰老的9个不同年龄段的联想学习及其抑制中的作用。研究结果将提供一个新的神经科学框架，以了解整个生命过程中的学习和记忆，这将促进新的研究机会，并为我们的教育和健康提供信息。