A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM
安全紧凑的新生儿到成人神经成像 MRI 系统
基本信息
- 批准号:10264552
- 负责人:
- 金额:$ 147.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-24 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:2 year oldAdultAffectAnatomyAnimalsBrainBrain imagingCaringChildChildhoodClinicalClinical TrialsComplexCongenital DisordersCustomDetectionDevelopmentDiagnosisDiffusionFeedbackFunctional Magnetic Resonance ImagingGoalsGrowthHeadHeart DiseasesHospital DepartmentsHospitalsHumanImageImage EnhancementImaging technologyIndividualInfantInjuryInterventionIonizing radiationLimb structureLung diseasesMagnetic Resonance ImagingMapsMeasuresMental HealthMental disordersMusculoskeletal DiseasesNeonatalNeonatal Intensive Care UnitsNeurodegenerative DisordersNewborn InfantOrganOutcomePatient CarePatientsPerformancePhaseRF coilRadiology SpecialtyResearchResearch SupportResolutionRiskSafetyScanningSerial Magnetic Resonance ImagingSmall Business Innovation Research GrantStrokeSystemTechnologyTestingTimeUnited States National Institutes of Healthanimal imagingbasebrain magnetic resonance imagingcardiac intensive care unitconnectomecostdesigndiagnostic tooleffectiveness validationhigh risk infantimaging systeminnovationneonatenervous system disorderneuroimagingpediatric patientspreterm newbornprototyperepairedsuccesstooltrendwhole body imaging
项目摘要
NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System
The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using
magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to
assess injury mechanisms affecting newborn growth and the adult human connectome. To predict neuro-
developmental outcome necessary to validate effectiveness of therapy in infants and adults, mapping
dynamic anatomical and functional connectivity in the human brain is essential. However, many unstable
premature newborns are kept from stat MRI diagnosis because transport to adult MRIs located remotely
in the radiology department is highly risky. Serial MRI necessary to validate effectiveness of therapy or
clinical intervention requiring multiple transports between the neonatal intensive care unit (NICU) and MRI
sections places additional burden on the NICU staff and the baby. In its current form adult MRI's with many
unrelated and unsuitable features for kids are expensive, complex and impractical for routine clinical use.
The overall goal of this SBIR project is to create a compact MRI system, by combining innovations in
patient-centric care and salient imaging technology. This safe system can be installed for whole-body
imaging of sick children in the neonatal, pediatric and cardiac intensive care units. The `low-intrinsic risk'
design ideal for safe pediatric use will be widely accepted by the hospital staff. The compact MRI is
concurrently designed for imaging the adult brain, and suitable for installation in any hospital department
or on a truck. The human connectome project (HCP) uses diffusion and BOLD-based functional MRI to
derive whole-brain structural and functional connectivity maps for individual subjects at 1.25-2mm
resolution (2-8µL voxels). Our research imaging goals are to attain targets between 0.125µL and 0.5µL
isotropic voxels with the 100mT/m strong gradients over the neonatal and adult brain in support of research
in reasonable scan times. Enhanced image quality obtained with the strong gradients can help unravel
brain development and repair associated with a variety of neurological, psychiatric, neurodegenerative and
congenital disorders. Our technology alleviates cost and safety burdens imposed by large foot-print adult
whole-body MRIs on the hospital and pediatric patients. Multiple uses of the custom, compact MRI system
with its combined patient-centric care and radiology approach proposed is original. A successful project
will shift the trend from radiology based scanners to clinical departments where stat diagnosis is possible
for pediatric patients and adults. Success of this project will stimulate development of a mobile mental
health and stroke detection MRI systems, ultra-compact MRIs for extremity and small animal imaging, and
mid- to low-field off-grid MRI for world use. A safer compact MRI for 0-2 year olds and adult is needed and
will dramatically increase the quality of clinical MRI and connectome research. This project will also support
advanced diagnosis in patients with lung, cardiac and musculoskeletal disorders.
美国国立卫生研究院SBIR PA-18-871无临床试验一种安全紧凑的新生儿到成人神经成像MRI系统
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ravi Srinivasan其他文献
Ravi Srinivasan的其他文献
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{{ truncateString('Ravi Srinivasan', 18)}}的其他基金
ADVANCED COMPREHENSIVE MAGNETIC RESONANCE SOLUTION FOR THE NONINVASIVE CHARACTERIZATION OF HIGH RESOLUTION METABOLIC BIOMARKERS OF RISK IN PATIENTS WITH ALZHEIMER'S DISEASE AND DEMENTIA
先进的综合磁共振解决方案,用于无创表征阿尔茨海默病和痴呆症患者风险的高分辨率代谢生物标志物
- 批准号:
10820517 - 财政年份:2023
- 资助金额:
$ 147.21万 - 项目类别:
A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM
安全紧凑的新生儿到成人神经成像 MRI 系统
- 批准号:
10023285 - 财政年份:2019
- 资助金额:
$ 147.21万 - 项目类别:
A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM
安全紧凑的新生儿到成人神经成像 MRI 系统
- 批准号:
10591472 - 财政年份:2019
- 资助金额:
$ 147.21万 - 项目类别:
ADVANCED NEXT GEENRATION RADIO FREQUENCY COILS FOR MAGNETIC RESONANCE IMAGING
用于磁共振成像的先进下一代射频线圈
- 批准号:
10019730 - 财政年份:2019
- 资助金额:
$ 147.21万 - 项目类别:
A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM
安全紧凑的新生儿到成人神经成像 MRI 系统
- 批准号:
9897423 - 财政年份:2019
- 资助金额:
$ 147.21万 - 项目类别:
Dual Tuned Head Array for MRI/MRS of the Human Brain
用于人脑 MRI/MRS 的双调谐头阵列
- 批准号:
7109800 - 财政年份:2006
- 资助金额:
$ 147.21万 - 项目类别:
Contoured Array for High Resolution Fetal MRI
用于高分辨率胎儿 MRI 的轮廓阵列
- 批准号:
7106303 - 财政年份:2006
- 资助金额:
$ 147.21万 - 项目类别:
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