A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM

NIH SBIR PA-18-871无/无临床试验一种安全紧凑的新生儿到成人神经成像MRI系统 耐人寻味的人脑是成像最多的终末器官，无创，无电离辐射使用 磁共振成像(MRI)。高空间分辨率脑MRI是一种成熟的诊断工具 评估影响新生儿生长和成人人体连接体的损伤机制。去预测神经- 婴儿和成人验证治疗有效性所需的发育结果，地图 人脑的动态解剖和功能连接是必不可少的。然而，许多人不稳定 早产儿无法进行静态核磁共振诊断，因为运送到远程的成人核磁共振检查 在放射科工作是非常危险的。验证治疗效果所需的系列MRI或 临床干预需要在新生儿重症监护病房(NICU)和核磁共振之间进行多次转运 分区给NICU工作人员和婴儿带来了额外的负担。在目前的形式下，成人核磁共振成像有许多 不相关和不适合儿童的功能是昂贵的、复杂的，对于常规的临床使用是不切实际的。 该SBIR项目的总体目标是通过结合以下创新来创建紧凑的MRI系统 以患者为中心的护理和卓越的成像技术。该安全系统可安装于全身。 新生儿、儿科和心脏重症监护病房中患病儿童的成像。“低内在风险” 儿科安全使用的理想设计将被医院工作人员广泛接受。紧凑型磁共振成像是 同时设计用于成人大脑成像，适合在任何医院科室安装 或者在卡车上。人类连接体项目(HCP)使用扩散和基于BOLD的功能磁共振成像来 在1.25-2 mm处绘制单个受试者的全脑结构和功能连接图 分辨率(2-8微米L体素)。我们的研究成像目标是达到0.125微米L到0.5微米L之间的目标 新生儿和成人大脑上方100mT/m强梯度的各向同性体素以支持研究 在合理的扫描时间内。使用强梯度获得的增强图像质量可以帮助解开 大脑的发育和修复与各种神经、精神、神经退行性和 先天性疾病。我们的技术减轻了大脚印成年人造成的成本和安全负担 医院和儿科病人的全身核磁共振检查。定制、紧凑型MRI系统的多种用途 其以病人为中心的护理和放射学相结合的方法是独创的。一个成功的项目 将把趋势从基于放射学的扫描仪转移到可以进行统计诊断的临床科室 适用于儿科病人和成人。该项目的成功将刺激移动心理的发展 健康和中风检测核磁共振系统，用于肢体和小动物成像的超小型核磁共振成像，以及 全球使用的中低场离网核磁共振成像。0-2岁儿童和成人需要更安全的紧凑型磁共振成像， 将极大地提高临床核磁共振和连接组研究的质量。该项目还将支持 肺、心脏和肌肉骨骼疾病患者的高级诊断。

NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predict neuro- developmental outcome necessary to validate effectiveness of therapy in infants and adults, mapping dynamic anatomical and functional connectivity in the human brain is essential. However, many unstable premature newborns are kept from stat MRI diagnosis because transport to adult MRIs located remotely in the radiology department is highly risky. Serial MRI necessary to validate effectiveness of therapy or clinical intervention requiring multiple transports between the neonatal intensive care unit (NICU) and MRI sections places additional burden on the NICU staff and the baby. In its current form adult MRI's with many unrelated and unsuitable features for kids are expensive, complex and impractical for routine clinical use. The overall goal of this SBIR project is to create a compact MRI system, by combining innovations in patient-centric care and salient imaging technology. This safe system can be installed for whole-body imaging of sick children in the neonatal, pediatric and cardiac intensive care units. The `low-intrinsic risk' design ideal for safe pediatric use will be widely accepted by the hospital staff. The compact MRI is concurrently designed for imaging the adult brain, and suitable for installation in any hospital department or on a truck. The human connectome project (HCP) uses diffusion and BOLD-based functional MRI to derive whole-brain structural and functional connectivity maps for individual subjects at 1.25-2mm resolution (2-8µL voxels). Our research imaging goals are to attain targets between 0.125µL and 0.5µL isotropic voxels with the 100mT/m strong gradients over the neonatal and adult brain in support of research in reasonable scan times. Enhanced image quality obtained with the strong gradients can help unravel brain development and repair associated with a variety of neurological, psychiatric, neurodegenerative and congenital disorders. Our technology alleviates cost and safety burdens imposed by large foot-print adult whole-body MRIs on the hospital and pediatric patients. Multiple uses of the custom, compact MRI system with its combined patient-centric care and radiology approach proposed is original. A successful project will shift the trend from radiology based scanners to clinical departments where stat diagnosis is possible for pediatric patients and adults. Success of this project will stimulate development of a mobile mental health and stroke detection MRI systems, ultra-compact MRIs for extremity and small animal imaging, and mid- to low-field off-grid MRI for world use. A safer compact MRI for 0-2 year olds and adult is needed and will dramatically increase the quality of clinical MRI and connectome research. This project will also support advanced diagnosis in patients with lung, cardiac and musculoskeletal disorders.