A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM

NIH SBIR PA-18-871 w/o临床试验一种安全紧凑的新生儿至成人神经成像MRI系统 有趣的人类大脑是非侵入性成像最多的终末器官，没有电离辐射， 磁共振成像（MRI）。高空间分辨率脑MRI是一种既定的诊断工具， 评估影响新生儿生长和成人连接体的损伤机制。为了预测神经- 验证婴儿和成人治疗有效性所需的发育结局，绘制 人脑中的动态解剖和功能连接是必不可少的。然而，许多不稳定的 早产新生儿不能进行MRI诊断，因为运送到成人MRI位置较远， 在放射科是非常危险的验证治疗有效性所需的系列MRI，或 需要在新生儿重症监护室（NICU）和MRI之间进行多次转运的临床干预 这给NICU工作人员和婴儿带来了额外的负担。在其目前的形式成人磁共振成像的许多 对于常规临床使用来说，不相关的和不适合儿童的特征是昂贵、复杂和不切实际的。 该SBIR项目的总体目标是通过结合以下方面的创新来创建紧凑的MRI系统： 以患者为中心的护理和突出的成像技术。该安全系统可安装在全身 在新生儿、儿科和心脏重症监护病房为患病儿童进行成像。“低内在风险” 安全儿科使用的理想设计将被医院工作人员广泛接受。紧凑型MRI是 同时设计用于成像成人大脑，并适合安装在任何医院部门 或者卡车上人类连接体计划（HCP）使用扩散和基于BOLD的功能性MRI， 在1.25- 2 mm处获得个体受试者的全脑结构和功能连接图 分辨率（2-8µL体素）。我们的研究成像目标是达到0.125微升和0.5微升之间的目标 在新生儿和成人大脑上具有100 mT/m强梯度的各向同性体素，以支持研究 在合理的扫描时间。通过强梯度获得的增强图像质量有助于解开 大脑发育和修复与各种神经，精神，神经退行性和 先天性疾病我们的技术减轻了大脚印成人所带来的成本和安全负担 医院和儿科病人的全身核磁共振成像定制紧凑型MRI系统的多种用途 其结合以病人为中心的护理和放射学方法提出的是原创的。一个成功的项目 将从基于放射学的扫描仪转移到可能进行统计诊断的临床部门 儿童患者和成人。这个项目的成功将刺激移动的心理发展 健康和中风检测MRI系统，用于肢体和小动物成像的超紧凑型MRI，以及 中低场离网磁共振成像供世界使用。需要为0-2岁奥尔兹和成人提供更安全的紧凑型MRI， 将极大地提高临床MRI和连接体研究的质量。该项目还将支持 肺部、心脏和肌肉骨骼疾病患者的晚期诊断。

NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predict neuro- developmental outcome necessary to validate effectiveness of therapy in infants and adults, mapping dynamic anatomical and functional connectivity in the human brain is essential. However, many unstable premature newborns are kept from stat MRI diagnosis because transport to adult MRIs located remotely in the radiology department is highly risky. Serial MRI necessary to validate effectiveness of therapy or clinical intervention requiring multiple transports between the neonatal intensive care unit (NICU) and MRI sections places additional burden on the NICU staff and the baby. In its current form adult MRI's with many unrelated and unsuitable features for kids are expensive, complex and impractical for routine clinical use. The overall goal of this SBIR project is to create a compact MRI system, by combining innovations in patient-centric care and salient imaging technology. This safe system can be installed for whole-body imaging of sick children in the neonatal, pediatric and cardiac intensive care units. The `low-intrinsic risk' design ideal for safe pediatric use will be widely accepted by the hospital staff. The compact MRI is concurrently designed for imaging the adult brain, and suitable for installation in any hospital department or on a truck. The human connectome project (HCP) uses diffusion and BOLD-based functional MRI to derive whole-brain structural and functional connectivity maps for individual subjects at 1.25-2mm resolution (2-8µL voxels). Our research imaging goals are to attain targets between 0.125µL and 0.5µL isotropic voxels with the 100mT/m strong gradients over the neonatal and adult brain in support of research in reasonable scan times. Enhanced image quality obtained with the strong gradients can help unravel brain development and repair associated with a variety of neurological, psychiatric, neurodegenerative and congenital disorders. Our technology alleviates cost and safety burdens imposed by large foot-print adult whole-body MRIs on the hospital and pediatric patients. Multiple uses of the custom, compact MRI system with its combined patient-centric care and radiology approach proposed is original. A successful project will shift the trend from radiology based scanners to clinical departments where stat diagnosis is possible for pediatric patients and adults. Success of this project will stimulate development of a mobile mental health and stroke detection MRI systems, ultra-compact MRIs for extremity and small animal imaging, and mid- to low-field off-grid MRI for world use. A safer compact MRI for 0-2 year olds and adult is needed and will dramatically increase the quality of clinical MRI and connectome research. This project will also support advanced diagnosis in patients with lung, cardiac and musculoskeletal disorders.