Dual Tuned Head Array for MRI/MRS of the Human Brain

用于人脑 MRI/MRS 的双调谐头阵列

• 批准号: 7109800
• 负责人: Ravi Srinivasan
• 金额: $ 17.54万
• 依托单位: ADVANCED IMAGING RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7109800
• 关键词: brain; head; human; hydrogen ions

DESCRIPTION (provided by applicant): A long term goal is to improve the quality of magnetic resonance (MR) examinations of the human brain. Specifically, transmit/receive dual-tuned phosphorous-proton (31P-1H) head coil arrays capable of simultaneous operation will be developed to permit high-resolution proton MR imaging, proton MR spectroscopy and proton decoupled phosphorous spectroscopy in one clinical setting. Phase I will support development of 1.5T volume phosphorous and proton, actively detuneable transmit coils and multiple channel phosphorous receive array. The proposed dual tuned head array will be built and systematically verified on phantoms at 1.57. Comparisons to the comparable commercial devices to evaluate signal-to-noise and uniformity shall be made. Phase II will support design optimizations followed by volunteer evaluations to achieve improved phosphorous spectral quality over the brain at 1.5T. Proton receive arrays will be included and the "true" dual tuned Phosphorous-Proton transmit/receive head arrays will be extended to 3T. Design and development of custom devices for 7T is planned. Prototypes will be systematically verified on phantoms and compared to existing coils prior to human evaluations (under local IRB). In addition, Phase 2 will involve adaptating the devices to the big three (GE, Siemens, Philips) MRI OEMs. Potential research and clinical use include broad-based functional, structural and biochemical examinations of patients with neurodegenerative disease, such as stroke, epilepsy and alzheimers, cancer, neuropsychiatric diseases such as schizophrenia and AIDS etc. All this will translate in to improved image quality and spectroscopic representation of the x-nucleus over the adult brain in one patient setting, which will aid diagnosis. This we believe will be of a substantial benefit to mankind.

描述（由申请人提供）：长期目标是提高人脑磁共振（MR）检查的质量。具体来说，能够同时操作的发射/接收双调谐磷质子（31P-1H）头线圈阵列将被开发，以允许在一个临床环境中进行高分辨率质子磁共振成像，质子磁共振光谱和质子解耦磷光谱。一期将支持1.5T体积磷和质子、主动可调谐发射线圈和多通道磷接收阵列的开发。提出的双调谐头阵列将在1.57的幻影上建立和系统验证。应与同类商用设备进行比较，以评估信噪比和均匀性。第二阶段将支持设计优化，随后进行志愿者评估，以在1.5T下改善大脑上的磷光谱质量。质子接收阵列将包括在内，“真正的”双调谐磷质子发射/接收头阵列将扩展到3T。计划为7T设计和开发定制设备。原型将在模型上进行系统验证，并在人类评估之前与现有线圈进行比较（根据当地IRB）。此外，第二阶段将涉及使设备适应三大（GE，西门子，飞利浦）MRI oem。潜在的研究和临床应用包括对神经退行性疾病，如中风、癫痫和阿尔茨海默病、癌症、神经精神疾病，如精神分裂症和艾滋病等患者进行广泛的功能、结构和生化检查。所有这些都将转化为在一个患者环境中提高成人大脑x核的图像质量和光谱表现，这将有助于诊断。我们相信这将对人类有重大的好处。