NOVEL RF COILS FOR IMAGING NEONATES

用于新生儿成像的新型射频线圈

• 批准号: 6806042
• 负责人: Ravi Srinivasan
• 金额: $ 60.78万
• 依托单位: ADVANCED IMAGING RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6806042
• 关键词: NOVEL; RF; COILS; IMAGING; NEONATES

DESCRIPTION (provided by applicant): A long-term goal is to permit routine magnetic resonance examinations of critically ill pre and term neonates. We intend to accomplish this by adapting the radio-frequency (RF) coils developed in this project to the stand-alone incubator system developed elsewhere. More specifically, this proposal will develop high performance RF coils to enable high resolution imaging of the brain, spine and heart of sick pre and term neonates. Our coils will be interfaced to General Electric (Signa), Siemens (Symphony, Sonata) and Philips (Eclipse) 1.5T and GE 3T Magnetic Resonance systems. All of the RF coils developed will be systematically evaluated with phantoms and compared to existing devices. This will be followed by clinical verifications on a small number of ill patients with the assistance of our collaborators from the neonatology and radiology departments, on the 1.5 and 3T GE Signa at the Children's Hospital of Los Angeles and 1.5T Philips Eclipse MRI at the MetroHealth Medical Center. In addition, specific absorption rate (SAR) measurements will be made for our transmit/receive coils using the energy per pulse method at 1.5T and 3T. With the incubator system, sick neonates can be safely transported and scanned using MR. High quality data obtained with high signal-to-noise (S/N) custom coils may assist in the prognosis/diagnosis of illnesses which in turn may lead to prompt clinical (surgical, pharmaceutical) interventions which in turn may save many precious lives. This we believe will be a significant benefit to mankind. The significance of the work proposed is paramount.

描述（由申请人提供）： 一个长期目标是允许常规磁共振检查的危重早产儿和足月新生儿。 我们打算通过调整本项目中开发的射频（RF）线圈来实现这一目标，以适应其他地方开发的独立培养箱系统。更具体地说，该提案将开发高性能RF线圈，以实现患病早产儿和足月新生儿的大脑、脊柱和心脏的高分辨率成像。我们的线圈将连接到通用电气（Signa）、西门子（Symphony、Sonata）和飞利浦（Eclipse）1.5T和GE 3 T磁共振系统。所有开发的射频线圈都将使用体模进行系统评价，并与现有器械进行比较。随后将在我们来自泌尿科和放射科的合作者的协助下，在洛杉矶儿童医院的1.5 T和3 T GE Signa以及MetroHealth医疗中心的1.5 T Philips Eclipse MRI上对少数患者进行临床验证。此外，将在1.5T和3 T下使用每脉冲能量法对我们的发射/接收线圈进行比吸收率（SAR）测量。 使用高信噪比（S/N）定制线圈获得的高质量数据可以帮助疾病的预后/诊断，这反过来又可能导致及时的临床（手术，药物）干预，这反过来又可能挽救许多宝贵的生命。我们认为这将给人类带来重大利益。 所提议的工作的重要性是至关重要的。