Glycemic Profile of Pregnancy Consortium Biostatistics Research Center

妊娠联盟生物统计研究中心的血糖概况

• 批准号: 10229496
• 负责人: Denise M Scholtens
• 金额: $ 154.69万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10229496
• 关键词: Address; Adolescence; Area; Biometry; Birth; Birth trauma; Case Report Form; Cesarean section; Charge; Child; Childhood; Clinical; Clinical Trials; Communication; Data; Data Analyses; Development; Diabetes Mellitus; Diagnosis; Dystocia; Faculty; Follow-Up Studies; Generations; Gestational Diabetes; Glucose; Glucose Metabolism Disorders; High birth weight infant; Human Resources; Hyperglycemia; International; Investigation; Laboratories; Lead; Leadership; Link; Measures; Metabolic Diseases; Methodology; Modeling; Monitor; Mothers; Multicenter Studies; National Institute of Diabetes and Digestive and Kidney Diseases; Newborn Infant; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Outcome; Outcome Study; Population Research; Pregnancy; Pregnancy Complications; Pregnancy in Diabetics; Pregnant Women; Procedures; Publications; Reproducibility; Research; Research Design; Resources; Risk Factors; Role; Sampling; Shoulder; Statistical Data Interpretation; Statistical Models; Structure; Technology; Translations; Universities; Work; adverse pregnancy outcome; base; central database; clinical center; data modeling; data quality; design; diagnostic criteria; early pregnancy; experience; fetal programming; follow-up; glucose metabolism; glucose monitor; high risk; implementation design; innovation; insight; long-term sequelae; maternal hyperglycemia; meetings; member; method development; multiple data types; newborn adiposity; novel; offspring; perinatal outcomes; perinatal period; protocol development; quality assurance; screening; sensor

PROJECT SUMMARY Maternal hyperglycemia during pregnancy is a known risk factor for high birthweight, excessive newborn adiposity, and related pregnancy complications including cesarean delivery, shoulder dystocia and birth injury. Sequelae of elevated pregnancy glucose are not limited to the perinatal period. Mothers meeting criteria for gestational diabetes are more likely to develop long-term metabolic disorders including Type 2 diabetes. Maternal glucose also has an apparent sustained influence on fetal programming, with offspring of hyperglycemic mothers at higher risk of both excess adiposity and disordered glucose metabolism throughout childhood and into adolescence. While debate exists as to specific criteria that should be used for diagnosing gestational diabetes, it is the case that adverse maternal and offspring outcomes related to both anthropometrics and glucose metabolism, both at delivery and over a decade later, are associated with maternal glucose values across the continuum. Existing diagnostic criteria for gestational diabetes are based on measures of maternal glucose, typically at ~28 weeks' gestation. To more fully elucidate maternal glycemia and identify potential early indicators of gestational diabetes, Clinical Centers comprising the National Institute of Diabetes and Digestive and Kidney Diseases' Glycemic Profile of Pregnancy Consortium will be charged with designing a multicenter observational study of pregnant mothers without pre-existing diabetes to richly characterize maternal glycemic profiles using sensor-based continuous glucose monitoring technology. The Northwestern University Biostatistics Research Center proposes to serve as a central leadership hub for the Glycemic Profile of Pregnancy Consortium, coordinating all data-related and operational activities using cutting-edge resources for study design, planning and conduct, ongoing data monitoring and statistical analysis.

项目摘要 妊娠期母体高血糖是导致高出生体重、新生儿体重超标的已知危险因素。 肥胖症和相关的妊娠并发症，包括剖宫产、肩难产和产伤。 妊娠期血糖升高的后遗症不仅限于围产期。符合以下标准的母亲： 妊娠期糖尿病更容易发展为长期代谢紊乱，包括2型糖尿病。 母体葡萄糖也对胎儿编程有明显的持续影响， 高血糖母亲在整个过程中有更高的过度肥胖和糖代谢紊乱的风险 童年和青春期。虽然存在着关于应用于诊断的具体标准的争论 妊娠期糖尿病，这是一种情况下，不利的母亲和后代的结果有关， 分娩时和十多年后的人体测量学和葡萄糖代谢， 母体葡萄糖值的变化。妊娠糖尿病的现有诊断标准是基于 测量母体葡萄糖，通常在妊娠约28周时。为了更全面地阐明母亲的 并确定妊娠糖尿病的潜在早期指标，临床中心包括国家研究所 糖尿病、消化和肾脏疾病妊娠联盟的血糖谱将被收费 通过设计一项多中心观察性研究， 使用基于传感器的连续葡萄糖监测技术表征母体血糖谱。的 西北大学生物统计学研究中心建议作为一个中央领导枢纽， 妊娠联盟的Glycerol Profile，协调所有与数据有关的业务活动， 用于研究设计、规划和实施、持续数据监测和统计的尖端资源 分析.