Glycemic Profile of Pregnancy Consortium Biostatistics Research Center

项目总结 孕妇孕期高血糖是已知的高出生体重、过多新生儿的危险因素 肥胖和相关的妊娠并发症，包括剖腹产、肩部难产和产伤。 妊娠期血糖升高的后遗症并不局限于围产期。符合以下标准的母亲 妊娠期糖尿病更有可能发展为包括2型糖尿病在内的长期代谢紊乱。 母体葡萄糖对胎儿程序化也有明显的持续影响，其后代 高血糖母亲在整个过程中都有更高的肥胖和糖代谢紊乱风险 从童年到青春期。虽然对于应该用于诊断的特定标准存在争议 妊娠期糖尿病，即母亲和子女的不良结局与 人体测量学和葡萄糖代谢，在分娩时和十多年后，都与 整个过程中的母体血糖值。现有的妊娠期糖尿病诊断标准是基于 测量孕妇血糖，通常是在怀孕约28周时。为了更全面地阐明母体血糖 并确定潜在的妊娠期糖尿病早期指标，由国家研究所组成的临床中心 糖尿病及消化和肾脏疾病孕妇联盟的血糖谱将被收费 通过设计一项对没有既往糖尿病的孕妇进行的多中心观察研究， 使用基于传感器的连续血糖监测技术来表征母亲的血糖水平。这个 西北大学生物统计研究中心建议作为中央领导中心 妊娠联盟的血糖状况，协调所有与数据有关的业务活动 用于研究设计、规划和实施、持续数据监测和统计的尖端资源 分析。

PROJECT SUMMARY Maternal hyperglycemia during pregnancy is a known risk factor for high birthweight, excessive newborn adiposity, and related pregnancy complications including cesarean delivery, shoulder dystocia and birth injury. Sequelae of elevated pregnancy glucose are not limited to the perinatal period. Mothers meeting criteria for gestational diabetes are more likely to develop long-term metabolic disorders including Type 2 diabetes. Maternal glucose also has an apparent sustained influence on fetal programming, with offspring of hyperglycemic mothers at higher risk of both excess adiposity and disordered glucose metabolism throughout childhood and into adolescence. While debate exists as to specific criteria that should be used for diagnosing gestational diabetes, it is the case that adverse maternal and offspring outcomes related to both anthropometrics and glucose metabolism, both at delivery and over a decade later, are associated with maternal glucose values across the continuum. Existing diagnostic criteria for gestational diabetes are based on measures of maternal glucose, typically at ~28 weeks' gestation. To more fully elucidate maternal glycemia and identify potential early indicators of gestational diabetes, Clinical Centers comprising the National Institute of Diabetes and Digestive and Kidney Diseases' Glycemic Profile of Pregnancy Consortium will be charged with designing a multicenter observational study of pregnant mothers without pre-existing diabetes to richly characterize maternal glycemic profiles using sensor-based continuous glucose monitoring technology. The Northwestern University Biostatistics Research Center proposes to serve as a central leadership hub for the Glycemic Profile of Pregnancy Consortium, coordinating all data-related and operational activities using cutting-edge resources for study design, planning and conduct, ongoing data monitoring and statistical analysis.