MIND Institute Intellectual and Developmental Disabilities Research Center

项目概要-总体 本申请寻求资金，以继续智力和发展研究所 残疾人研究中心（IDDRC）在加州大学戴维斯分校。IDDRC于2013年启动 并且是网络中14个IDDRC中最新的一个。MIND研究所IDDRC将致力于四个具体目标。 目标1是进行跨学科的翻译研究，深入了解自然，原因， 这将有助于消除缺碘症的严重后果，并导致采取以证据为基础的创新性预防和治疗方法。本 最后，我们提出了81个外部资助的项目，反映了综合生物行为的主题 IDD的特征，IDD的遗传和环境因素，以及IDD的治疗。这些项目 由来自16个学系及5所学校/学院的43名调查员带领。68个项目由 其中16个由NICHD提供。目标2是通过跨学科的翻译研究， 具有成本效益、创新和广泛使用的科学核心的运作。除了行政核心，我们 提出四个科学核心。临床翻译核心将促进招募不同的样本， 人类参与者，提供专业的临床专业知识来诊断和表征参与者，支持 复杂的表型分析，收集和存储生物标本，并将数字技术整合到治疗研究中。 生物和分子分析核心将提供以下领域的专业知识和技术 免疫功能、细胞和分子成像、表观遗传学和环境暴露， 神经发育啮齿动物行为核心将提供小鼠和大鼠行为的测定， 开发突变啮齿动物模型，并支持药物安全性和有效性的临床前评价。的 生物统计学、生物信息学和研究设计核心将为研究设计、创建 电子数据采集和管理系统，以及复杂多维数据集的统计分析。 目标3是改善缺碘症患者的生活，减少保健方面的健康和社会差距， 一个传播和实施科学发现的有力计划。该计划将涉及多种途径， 与目标专业人员和决策者沟通，接触不同社区，同时了解 IDD患者及其家人的观点。目标4是开展一项标志性研究项目， 探讨了母体自身抗体的结果和机制的异质性，这些结果的基础 自闭症谱系障碍（ASD）可能占ASD病例的20%。的 该项目将利用现有的人类临床数据，为建立大鼠模型系统提供信息， 关于因果机制的假设。该签名项目涉及RFA的三个主题：预防和 减轻可能导致IDD的暴露的影响，干预措施的结局指标或生物标志物，或 治疗，以及开发一种以上IDD疾病的生物标志物或评估措施。

PROJECT SUMMARY – OVERALL The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The MIND Institute IDDRC will address four specific aims. Aim 1 is to conduct interdisciplinary translational research that yields insights into the nature, causes, and consequences of IDD and leads to innovative evidence-based approaches to prevention and treatment. To this end, we propose 81 externally funded projects that reflect the themes of Integrated Biobehavioral Characterization of IDD, Genetic and Environmental Contributions to IDD, and Treatment of IDD. These projects are led by 43 investigators from 16 academic departments and 5 schools/colleges. 68 projects are funded by the NIH, including 16 by NICHD. Aim 2 is to accelerate the pace of interdisciplinary translational research via the operation of cost-effective, innovative, and widely used scientific cores. In addition to an Administrative Core, we propose four scientific cores. The Clinical Translational Core will facilitate recruitment of diverse samples of human participants, provide specialized clinical expertise to diagnose and characterize participants, support complex phenotyping, collect and store biospecimens, and integrate digital technologies into treatment studies. The Biological and Molecular Analysis Core will provide access to expertise and technologies in the areas of immune function, cellular and molecular imaging, epigenetics, and environmental exposures as they relate to neural development. The Rodent Behavior Core will provide assays of mouse and rat behavior, guidance in the development of mutant rodent models, and support for preclinical evaluations of drug safety and efficacy. The Biostatistics, Bioinformatics, and Research Design Core will provide support for study design, creation of electronic data capture and management systems, and statistical analysis of complex multidimensional datasets. Aim 3 is to improve the lives of people with IDD and reduce health and social disparities in care by developing a robust plan for disseminating and implementing scientific discoveries. The plan will involve multiple paths of communication to target professionals and policy makers, reach diverse communities, while being informed by the perspectives of people with IDD and their families. Aim 4 is to conduct a signature research project that examines the heterogeneity of outcomes and mechanisms underlying those outcomes in maternal autoantibody related (MAR) autism spectrum disorder (ASD), which may account for as much as 20% of ASD cases. The project will make use of existing human clinical data to inform the creation of rat model systems to test hypotheses about causal mechanisms. The signature project addresses three RFA themes: Preventing and mitigating the impact of exposures that can cause IDD, Outcome measures or biomarkers for interventions or treatments, and Development of biomarkers or assessment measures in more than one IDD condition.