Mentoring Diabetes Research in Oklahoma

摘要 俄克拉荷马州是美国糖尿病患病率最高的州之一，有10%的人口 受影响。糖尿病在美洲原住民社区中尤其普遍，在那里它影响多达40%的 一些部落中年纪较大的人。因此，糖尿病及其并发症对工作人员构成了重大威胁-- 老龄化和人口老龄化，并给俄克拉何马州带来巨大的社会和经济负担。 Cobre的目标是加强俄克拉荷马州的糖尿病研究。在第一阶段和第二阶段，我们的Cobre 取得了里程碑的成就。所有由科布雷资助的初级调查人员都获得了独立拨款， 包括八项NIH R01拨款、两项R21拨款以及来自美国等基金会的多项拨款 糖尿病协会和美国心脏协会。我们的五名初级调查员已被提升 被授予副教授，其中三人迄今已获得终身教职。此外，由于他们在 研究表明，他们中的两人获得了捐赠的主席职位。在他们之间，初级调查人员已经发布了 207篇同行评审的论文，其中135篇得到了科布雷资助的核心机构的支持。与 科布雷医学院招募了3名NIH R01资助的糖尿病患者和1名K99/R00资助的糖尿病患者 俄克拉荷马大学健康科学中心(OUHSC)的研究人员。科布雷资助的核心 向多个私人投资机构提供支持和服务，并支持他们的出版物和国家卫生研究院资助的赠款，这些 俄克拉荷马州加强糖尿病研究。在科布雷计划的第三阶段，我们计划维持和扩大 这些成功。我们将继续支持和指导从 科布雷。我们将扩大和改善核心设施，为俄克拉荷马州的糖尿病研究提供服务，并完成 将科布雷资助的设施转变为机构研究核心。我们将进一步增加关键的 通过促进OUHSC招募糖尿病研究人员，在俄克拉何马州开展大量糖尿病研究。 此外，我们将继续促进合作和翻译研究。这些努力应该有助于 不断增长的糖尿病研究，以实现我们成为NIH P30资助的糖尿病患者的目标 研究中心(DRC)。该中心将极大地改善糖尿病的预防和治疗。

SUMMARY Oklahoma is one of the states in the US with the highest prevalence of diabetes, with 10% of the population affected. Diabetes is particularly prevalent among Native American communities, where it affects up to 40% of older individuals in some tribes. Thus, diabetes and its complications constitute a major threat to the working- age and older population, and confer an immense social and economic burden on Oklahoma. The goal of this COBRE is to enhance diabetes research in Oklahoma. In Phase I and Phase II, our COBRE achieved its milestones. All of the COBRE-supported Junior Investigators have received independent grants, including eight NIH R01 grants, two R21 grants, and multiple grants from foundations such as the American Diabetes Association and the American Heart Association. Five of our Junior Investigators have been promoted to Associate Professor, and three of them have received tenure thus far. In addition, because of their success in research, two of them received endowed chair positions. Between them, the Junior Investigators have published 207 peer-reviewed papers, 135 of which received support from COBRE-funded Cores. In collaboration with the College of Medicine, the COBRE has recruited three NIH R01-funded and 1 K99/R00-funded diabetes researchers into The University of Oklahoma Health Sciences Center (OUHSC). The COBRE-funded Cores have provided support and service to multiple PIs and supported their publications and NIH-funded grants, which enhanced diabetes research in Oklahoma. In Phase III of the COBRE program, we plan to sustain and augment these successes. We will continue supporting and mentoring Junior Investigators who graduated from the COBRE. We will expand and improve Core facilities to serve diabetes research in Oklahoma and complete transition of the COBRE-funded facilities into institutional research Cores. We will further increase the critical mass of diabetes research in Oklahoma by promoting recruitment of diabetes researchers into OUHSC. Moreover, we will continue promoting collaborative and translational research. These efforts should contribute to continuous growth of diabetes research to achieve our goal of becoming a NIH P30-funded Diabetes Research Center (DRC). This Center should greatly improve prevention and treatment of diabetes.