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Mentoring Diabetes Research in Oklahoma

指导俄克拉荷马州的糖尿病研究

基本信息

批准号：
10219291
负责人：
YUN Zheng LE
金额：
$ 111万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10219291
关键词：
Affect Age American American Heart Association Animal Model Area Basic Science California Centers of Research Excellence Clinical Clinical Research Collaborations Communities Core Facility Development Diabetes Mellitus Diagnosis Economic Burden Fees Fostering Foundations Funding Goals Grant Growth Health Sciences High Prevalence Human Individual Infrastructure Institution Joints Leadership Medicine Mentors Native Americans Nutritional Science Oklahoma Older Population Paper Peer Review Phase Pilot Projects Population Positioning Attribute Prevention Program Research Project Grants Progress Reports Publications Publishing Research Research Personnel Research Project Grants Research Support Resources Role Sampling Scientist Seeds Services Strategic Planning Translating Translational Research Translations Tribes United States National Institutes of Health Universities career college diabetic patient improved mid-career faculty programs ranpirnase recruit research facility social success

项目摘要

SUMMARY Oklahoma is one of the states in the US with the highest prevalence of diabetes, with 10% of the population affected. Diabetes is particularly prevalent among Native American communities, where it affects up to 40% of older individuals in some tribes. Thus, diabetes and its complications constitute a major threat to the working- age and older population, and confer an immense social and economic burden on Oklahoma. The goal of this COBRE is to enhance diabetes research in Oklahoma. In Phase I and Phase II, our COBRE achieved its milestones. All of the COBRE-supported Junior Investigators have received independent grants, including eight NIH R01 grants, two R21 grants, and multiple grants from foundations such as the American Diabetes Association and the American Heart Association. Five of our Junior Investigators have been promoted to Associate Professor, and three of them have received tenure thus far. In addition, because of their success in research, two of them received endowed chair positions. Between them, the Junior Investigators have published 207 peer-reviewed papers, 135 of which received support from COBRE-funded Cores. In collaboration with the College of Medicine, the COBRE has recruited three NIH R01-funded and 1 K99/R00-funded diabetes researchers into The University of Oklahoma Health Sciences Center (OUHSC). The COBRE-funded Cores have provided support and service to multiple PIs and supported their publications and NIH-funded grants, which enhanced diabetes research in Oklahoma. In Phase III of the COBRE program, we plan to sustain and augment these successes. We will continue supporting and mentoring Junior Investigators who graduated from the COBRE. We will expand and improve Core facilities to serve diabetes research in Oklahoma and complete transition of the COBRE-funded facilities into institutional research Cores. We will further increase the critical mass of diabetes research in Oklahoma by promoting recruitment of diabetes researchers into OUHSC. Moreover, we will continue promoting collaborative and translational research. These efforts should contribute to continuous growth of diabetes research to achieve our goal of becoming a NIH P30-funded Diabetes Research Center (DRC). This Center should greatly improve prevention and treatment of diabetes.

总结俄克拉荷马州是美国糖尿病患病率最高的州之一，占人口的10 影响。糖尿病在美洲原住民社区中特别普遍，在那里它影响了高达40%的人。一些部落中的老人因此，糖尿病及其并发症构成了对工作的主要威胁，年龄和老年人口，并赋予俄克拉荷马州巨大的社会和经济负担。这个COBRE的目标是加强俄克拉荷马州的糖尿病研究。在第一阶段和第二阶段，我们的COBRE 实现了里程碑。所有COBRE-supported初级调查员都收到了独立的赠款，包括八个NIH R 01赠款，两个R21赠款，以及来自美国基金会等基金会的多个赠款。糖尿病协会和美国心脏协会。我们的五名初级调查员到目前为止，他们中的三个人已经获得了终身教职。此外，由于他们在研究，其中两人获得了捐赠的椅子位置。在他们之间，初级调查员发表了 207篇同行评审论文，其中135篇得到了COBREs资助的Cores的支持。联同 COBRE招募了3名NIH R 01资助和1名K99/R 00资助的糖尿病患者研究人员进入俄克拉荷马州大学健康科学中心（OUHSC）。COBRE资助的核心为多个PI提供支持和服务，并支持他们的出版物和NIH资助的赠款，在俄克拉荷马州加强糖尿病研究。在COBRE计划的第三阶段，我们计划维持和增强这些成功。我们将继续支持和指导毕业于眼镜蛇我们将扩大和改善核心设施，为俄克拉荷马州的糖尿病研究服务，将COBREF资助的设施转变为机构研究核心。我们将进一步提高关键在俄克拉荷马州，通过促进招募糖尿病研究人员进入OUHSC，开展大量的糖尿病研究。此外，我们将继续促进合作和转化研究。这些努力应有助于糖尿病研究的持续增长，以实现我们成为NIH P30资助糖尿病的目标。研究中心（DRC）。该中心将大大提高糖尿病的预防和治疗。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration.

DOI：
10.1167/iovs.17-22107
发表时间：
2017-08-01
期刊：
Investigative ophthalmology & visual science
影响因子：
4.4
作者：
Du M;Phelps E;Balangue MJ;Dockins A;Moiseyev G;Shin Y;Kane S;Otalora L;Ma JX;Farjo R;Farjo KM
通讯作者：
Farjo KM

Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1.