FASEB's The Molecular Mechanisms of Immune Cell Development and Function Conference

项目摘要 该提案要求对联合会赞助的2021年夏季研究会议提供部分支持 美国实验生物学学会（FASEB）关于“免疫的分子机制”的主题 细胞发育与功能”，这是这个非常成功的系列中的第10次会议。这次会议是 FASEB自2004年成立以来，每隔一年进行一次竞争性重新评估， 2003年夏天。本次会议的特点是：（1）高度重视分子生物学， 免疫细胞发育和功能中的基因调控，包括全基因组研究中出现的新见解 （2）紧密结合免疫受体基因的分子机制研究 基因组结构和远程基因组控制概念的重组和多样化;（3） 有意识地将不同类别的免疫细胞研究并列，以揭示更大的共享使用模式 （4）明确关注基因网络和信号网络 连接，而不是“一次一个基因”的研究，以提供生物学的全面解释， （5）创建整合会议主要分子/机制主题的新会议 与免疫肿瘤学，肠道稳态和自身免疫;（6）整合科学家的演讲， 从国际知名专家到初级博士后和研究生， 密集，所有全会方案，使学员容易接触到经验丰富的资深科学家，谁又获得 对年轻人个人想法的欣赏。(7)实施我们独特的财务模式， 请发言者放弃对他们参加会议的财政支助，以便将大部分资金用于支助 学员和年轻的调查人员正在建立自己的独立职业生涯。这些独特的特点是 围绕三个具体目标设计：目标1-传播最新和重要的进展和新的 分子免疫学的范例;目标2-创建一个高度互动的，支持性的和合议的 在许多不同培训阶段的科学家之间分享科学知识的环境， 职业发展，从而促进新的合作，扩大专业和指导网络， 和职业发展;以及目标3-加强参与、贡献和参与的个人的多样性， 并在免疫学和生物学研究领域取得更广泛的职业发展。 许多实验室不愿意或不能派有前途的受训人员参加重要会议， 试图建立自己独立职业生涯的调查人员往往无法支付会议费用 出席情况.所要求的支持对于使最有前途的受训人员和初级教员能够 在分子免疫学中公开展示他们的工作，并与他们的领导者在亲密的环境中互动。 领域本次会议得到了往届会议与会者的热烈反馈， 长期持续的强有力的授权。

PROJECT SUMMARY This proposal requests partial support for a 2021 Summer Research Conference sponsored by the Federation of American Societies for Experimental Biology (FASEB) on the subject of “Molecular Mechanisms of Immune Cell Development and Function”, the 10th conference in this highly successful series. This conference has been chosen for sponsorship by FASEB after a competitive re-evaluation every other year since its inception in summer 2003. The distinctive features of this conference are: (1) A strong emphasis on molecular biology of gene regulation in immune cell development and function, including new insights emerging from genome-wide and systems approaches; (2) Close integration of the study of molecular mechanisms of immune receptor gene recombination and diversification with concepts in genomic architecture and long-range genomic control; (3) Deliberate juxtaposition of research on different classes of immune cells to reveal larger patterns of shared use of molecular and developmental mechanisms; (4) An explicit focus on gene network and signaling network connections rather than “one gene at a time” studies to provide a comprehensive explanation of biological regulation; (5) Creation of new sessions that integrate the major molecular/mechanistic themes of the meeting with immuno-oncology, gut homeostasis, and autoimmunity; (6) Integration of presentations from scientists at many career levels, from internationally renowned experts to junior postdoctoral and graduate students, in an intensive, all-plenary program—allowing trainees easy access to experienced senior scientists who in turn gain an appreciation of the young people’s individual ideas. (7) Implementation of our unique financial model in which invited speakers forego financial support for their participation to allow the use of the majority of funds to support trainees and young investigators who are establishing their independent careers. These distinctive features are designed around three specific aims: Aim 1—To disseminate the most recent and important advances and new paradigms in molecular immunology; Aim 2—To create a highly interactive, supportive, and collegial environment for the sharing of scientific knowledge between scientists at many different stages of training and career development, thereby facilitating new collaborations, broadening of professional and mentoring networks, and career development; and Aim 3—To enhance diversity among the individuals who participate in, contribute to, and achieve career advancement in the field of immunology and biological research more broadly. Many laboratories are unwilling or unable to send promising trainees to important conferences and young investigators attempting to establish their independent careers are often unable to cover the costs of conference attendance. The support requested is crucial to make it possible for the most promising trainees and junior faculty in molecular immunology to publicly present their work and interact in an intimate setting with leaders in their field. This meeting has received enthusiastic feedback from conference attendees of previous meetings and a strong mandate for long-term continuation.