FASEB's The Molecular Mechanisms of Immune Cell Development and Function Conference

FASEB 免疫细胞发育和功能的分子机制会议

• 批准号: 10224401
• 负责人: David G. Schatz
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224401
• 关键词: American; Antigen Receptors; Architecture; Area; Autoimmunity; B cell differentiation; Biological; Biological Models; Biology; Budgets; Businesses; California; Canada; Career Mobility; Cell Communication; Cells; Chromatin; Clinical; Collaborations; DNA Repair; Development; Developmental Process; Disease; Educational workshop; Effector Cell; Ensure; Environment; Evaluation; Faculty; Feedback; Financial Support; Fostering; Functional disorder; Funding; Future; Gene Expression; Gene Expression Regulation; Gene Rearrangement; Genes; Genetic Recombination; Genome; Genomic DNA; Genomics; Health; Hematopoietic; Hematopoietic stem cells; Homeostasis; Human; Immune; Immune response; Immune system; Immunologic Receptors; Immunology; Immunooncology; Individual; Innate Immune System; International; Island; Knowledge; Laboratories; Letters; Lymphocyte; Malignant Neoplasms; Mentors; Modeling; Molecular; Molecular Biology; Molecular Immunology; Nova Scotia; Oral; Pattern; Postdoctoral Fellow; Receptor Gene; Regulation; Request for Proposals; Research; Research Personnel; Scientist; Senior Scientist; Series; Signal Pathway; Signal Transduction; Societies; Stem Cell Development; System; T-Cell Development; Thinking; Time; Training; Transcriptional Regulation; Travel; Underrepresented Minority; United States National Institutes of Health; Woman; Work; biological research; career; career development; cost; design; epigenomics; experience; gene function; genome integrity; genome-wide; graduate student; gut homeostasis; immune function; information processing; insight; leukemia; meetings; microorganism; minority scientist; posters; pre-doctoral; programs; response; scientific atmosphere; summer research; symposium; synergism; transcriptomics

PROJECT SUMMARY This proposal requests partial support for a 2021 Summer Research Conference sponsored by the Federation of American Societies for Experimental Biology (FASEB) on the subject of “Molecular Mechanisms of Immune Cell Development and Function”, the 10th conference in this highly successful series. This conference has been chosen for sponsorship by FASEB after a competitive re-evaluation every other year since its inception in summer 2003. The distinctive features of this conference are: (1) A strong emphasis on molecular biology of gene regulation in immune cell development and function, including new insights emerging from genome-wide and systems approaches; (2) Close integration of the study of molecular mechanisms of immune receptor gene recombination and diversification with concepts in genomic architecture and long-range genomic control; (3) Deliberate juxtaposition of research on different classes of immune cells to reveal larger patterns of shared use of molecular and developmental mechanisms; (4) An explicit focus on gene network and signaling network connections rather than “one gene at a time” studies to provide a comprehensive explanation of biological regulation; (5) Creation of new sessions that integrate the major molecular/mechanistic themes of the meeting with immuno-oncology, gut homeostasis, and autoimmunity; (6) Integration of presentations from scientists at many career levels, from internationally renowned experts to junior postdoctoral and graduate students, in an intensive, all-plenary program—allowing trainees easy access to experienced senior scientists who in turn gain an appreciation of the young people’s individual ideas. (7) Implementation of our unique financial model in which invited speakers forego financial support for their participation to allow the use of the majority of funds to support trainees and young investigators who are establishing their independent careers. These distinctive features are designed around three specific aims: Aim 1—To disseminate the most recent and important advances and new paradigms in molecular immunology; Aim 2—To create a highly interactive, supportive, and collegial environment for the sharing of scientific knowledge between scientists at many different stages of training and career development, thereby facilitating new collaborations, broadening of professional and mentoring networks, and career development; and Aim 3—To enhance diversity among the individuals who participate in, contribute to, and achieve career advancement in the field of immunology and biological research more broadly. Many laboratories are unwilling or unable to send promising trainees to important conferences and young investigators attempting to establish their independent careers are often unable to cover the costs of conference attendance. The support requested is crucial to make it possible for the most promising trainees and junior faculty in molecular immunology to publicly present their work and interact in an intimate setting with leaders in their field. This meeting has received enthusiastic feedback from conference attendees of previous meetings and a strong mandate for long-term continuation.

项目摘要 该提案要求对联邦赞助的2021年夏季研究会议进行部分支持 美国实验生物学社会（FASEB）关于“免疫分子机制的主题 细胞开发和功能”，这个非常成功的系列中的第十次会议。这次会议是 自一年以来，每隔一年就选择了FaseB的赞助 2003年夏季。这次会议的独特特征是：（1）非常强调 免疫细胞发育和功能中的基因调节，包括全基因组出现的新见解 和系统方法； （2）紧密整合免疫受体基因的分子机制 重组和多样化，具有基因组结构和远程基因组控制中的概念； （3） 故意对不同类别的免疫细胞的研究并置，以揭示更大的共享使用模式 分子和发育机制； （4）明确关注基因网络和信号网络 连接而不是“一次基因”研究，以提供对生物学的全面解释 规定; （5）创建整合会议的主要分子/机械主题的新会议 具有免疫肿瘤，肠道稳态和自身免疫性； （6）从科学家的演讲整合 从国际知名的专家到初级博士后和研究生，许多职业级别 密集的全样计划 - 允许学员轻松进入经验丰富的高级科学家 对年轻人的个人想法的欣赏。 （7）实施我们独特的财务模型 邀请演讲者放弃参与的财政支持，以允许使用大多数资金来支持 正在建立独立职业的学员和年轻的调查员。这些独特的特征是 围绕三个特定目标设计：目标1-传播最新和重要的进步和新的进步 分子免疫学范例；目标2 - 创建一个高度互动，支持和大学 在培训的许多不同阶段，科学家之间分享科学知识的环境和 职业发展，从而支持新的合作，扩大专业和心理网络， 和职业发展；和目标3-增强参与个人的多样性，做出贡献 更广泛地在免疫学和生物学研究领域实现职业发展。 许多实验室不愿意或无法向重要的会议发送诺言培训 试图建立独立职业的调查人员通常无法支付会议的费用 出勤。要求的支持对于使最有前途的培训和初级教师成为可能 在分子免疫学中，公开介绍他们的工作，并在与领导者的亲密环境中进行互动 场地。这次会议收到了以前会议的会议与会者的热情反馈和 长期延续的强大任务。