FASEB's The Molecular Mechanisms of Immune Cell Development and Function Conference

项目总结 该提案要求对联合会主办的2021年夏季研究会议提供部分支持 美国实验生物学学会(FASE B)关于“免疫的分子机制”的研究 细胞发育和功能“，这是这个非常成功的系列中的第10次会议。这次会议一直是 FASEB自#年成立以来每隔一年进行一次竞争性重新评估后，被选为FASEB的赞助商 2003年夏天。这次会议的鲜明特点是：(1)高度重视生物分子生物学 免疫细胞发育和功能中的基因调控，包括来自全基因组的新见解 (2)紧密结合免疫受体基因的分子机制研究 基因组结构和远程基因组控制概念的重组和多样化；(3) 故意将对不同类别免疫细胞的研究并列在一起，以揭示共享使用的更大模式 分子和发育机制；(4)明确关注基因网络和信号网络 联系，而不是“一次一个基因”的研究，以提供一个全面的生物学解释 管理；(5)设立新的会议，将会议的主要分子/机制主题结合起来 与免疫肿瘤学、肠道动态平衡和自身免疫有关；(6)整合科学家在 许多职业水平，从国际知名的专家到初级博士后和研究生，在 密集的全会计划-使学员能够轻松接触到经验丰富的资深科学家，这些科学家反过来又能获得 对年轻人个人想法的欣赏。(7)实施我们独特的财务模式： 受邀发言者放弃对他们的参与的财政支持，以允许使用大多数资金来支持 正在建立独立职业生涯的实习生和年轻的调查人员。这些鲜明的特征是 围绕三个具体目标设计：目标1--传播最新和最重要的进展和新的 分子免疫学的范例；目标2-创建一个高度互动、支持和合作的 为处于不同培训和培训阶段的科学家之间分享科学知识创造环境 职业发展，从而促进新的合作，扩大专业和指导网络， 和职业发展；以及目标3--增强参与、贡献 在更广泛的免疫学和生物研究领域实现职业发展。 许多实验室不愿意或没有能力将有前途的受训者送到重要的会议和年轻的 试图建立独立职业生涯的调查人员往往无法支付会议费用 出席率。所要求的支持对于使最有前途的实习生和初级教员成为可能是至关重要的 在分子免疫学中公开展示他们的工作，并在亲密的环境中与他们的 菲尔德。本次会议得到了历届会议与会者的热烈反馈和 长期持续的强大授权。

PROJECT SUMMARY This proposal requests partial support for a 2021 Summer Research Conference sponsored by the Federation of American Societies for Experimental Biology (FASEB) on the subject of “Molecular Mechanisms of Immune Cell Development and Function”, the 10th conference in this highly successful series. This conference has been chosen for sponsorship by FASEB after a competitive re-evaluation every other year since its inception in summer 2003. The distinctive features of this conference are: (1) A strong emphasis on molecular biology of gene regulation in immune cell development and function, including new insights emerging from genome-wide and systems approaches; (2) Close integration of the study of molecular mechanisms of immune receptor gene recombination and diversification with concepts in genomic architecture and long-range genomic control; (3) Deliberate juxtaposition of research on different classes of immune cells to reveal larger patterns of shared use of molecular and developmental mechanisms; (4) An explicit focus on gene network and signaling network connections rather than “one gene at a time” studies to provide a comprehensive explanation of biological regulation; (5) Creation of new sessions that integrate the major molecular/mechanistic themes of the meeting with immuno-oncology, gut homeostasis, and autoimmunity; (6) Integration of presentations from scientists at many career levels, from internationally renowned experts to junior postdoctoral and graduate students, in an intensive, all-plenary program—allowing trainees easy access to experienced senior scientists who in turn gain an appreciation of the young people’s individual ideas. (7) Implementation of our unique financial model in which invited speakers forego financial support for their participation to allow the use of the majority of funds to support trainees and young investigators who are establishing their independent careers. These distinctive features are designed around three specific aims: Aim 1—To disseminate the most recent and important advances and new paradigms in molecular immunology; Aim 2—To create a highly interactive, supportive, and collegial environment for the sharing of scientific knowledge between scientists at many different stages of training and career development, thereby facilitating new collaborations, broadening of professional and mentoring networks, and career development; and Aim 3—To enhance diversity among the individuals who participate in, contribute to, and achieve career advancement in the field of immunology and biological research more broadly. Many laboratories are unwilling or unable to send promising trainees to important conferences and young investigators attempting to establish their independent careers are often unable to cover the costs of conference attendance. The support requested is crucial to make it possible for the most promising trainees and junior faculty in molecular immunology to publicly present their work and interact in an intimate setting with leaders in their field. This meeting has received enthusiastic feedback from conference attendees of previous meetings and a strong mandate for long-term continuation.