Biospecimen Core

Biosecimen核：综述 Biospecimen Core是支持西北大学所有脑瘤研究的重要资源，并且是 尤其重要的是要确保所有项目都在孢子期内经历临床翻译 资金问题。与生物统计和生物信息学核心和管理核心的定期互动将确保 每个项目都实现了目标，并对脑肿瘤患者的护理产生了积极影响。 Biosecimen核心将作为中心与所有项目和核心进行广泛的互动 通过提供最高质量的组织，存储患者组织和可再生的肿瘤资源 分析服务，并提供神经病理咨询。核心主任霍宾斯基博士 以及联席主任Daniel Brat博士将监督银行标本的质量控制测试，并将 对每个孢子项目的患者组织和肿瘤模型进行所有基于显微镜的分析。 将开展Biosecimen核心活动，以实现以下目标： 目的1：为西北脑肿瘤研究人员提供脑肿瘤生物标本的注释 病人。 目标2：对所有生物检验品进行严格的质量控制。 目的3：扩增、储存和鉴定外科标本衍生品，包括PDX和癌症 干细胞(CSC)模型，以满足对可再生肿瘤细胞来源的持续需求。 目的4：用生物标本和神经病理学分析来支持孢子项目。

BIOSPECIMEN CORE: SUMMARY The Biospecimen Core is a vital resource that supports all brain tumor research at Northwestern, and is especially important in seeing that all projects experience clinical translation within the period of SPORE funding. Regular interactions with the Biostatistics & Bioinformatics Core and Administrative Core will ensure that each project achieves its objectives, and has positive impact on the care of brain tumor patients. The Biospecimen Core will have extensive interactions with all projects and cores by acting as the central repository of patient tissues and renewable tumor resources, by providing the highest quality of tissue analytical services, and by providing neuropathological consultation. The Director of the Core, Dr. Horbinski, as well as the Co-Director, Dr. Daniel Brat, will supervise quality control testing of banked specimens, and will perform all microscopy-based analyses of patient tissues and tumor models for each SPORE project. Biospecimen Core activities will be performed to accomplish the following aims: Aim 1: Provide Northwestern brain tumor researchers with annotated biospecimens from brain tumor patients. Aim 2: Subject all biospecimens to rigorous quality control. Aim 3: Propagate, bank, and characterize surgical specimen derivatives, including PDX and cancer stem cell (CSC) models, to meet ongoing needs for renewable tumor cell sources. Aim 4: Support SPORE projects with biospecimens and neuropathologic analyses.