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Biospecimen Core

生物样本核心

基本信息

批准号：
10224122
负责人：
Craig Michael Horbinski
金额：
$ 29.48万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-17 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10224122
关键词：
Autopsy Bioinformatics Biological Assay Biological Markers Biological Specimen Banks Biometry Blood Blood specimen Brain Neoplasms Caring Cell Line Cells Cerebrospinal Fluid Clinical Clinical Research Collection Consent Consultations Cryopreservation DNA Data Databases Development Diagnostic Engraftment Ensure Equipment and supply inventories Evaluation Freezing Funding Genes Glioma Histologic Hospitals Human Resources Immunocompromised Host Individual Institution Laboratory Research Lymphocyte Malignant Neoplasms Malignant neoplasm of brain Microscopy Modeling Molecular Molecular Profiling Mus Mutation Normal tissue morphology Operating Rooms Operative Surgical Procedures Paraffin Embedding Pathologic Patients Pattern Plasma Procedures Promega Protocols documentation Quality Control RNA analysis Recurrence Research Research Personnel Research Support Resistance Resources Sampling Secure Services Short Tandem Repeat Source Specimen Supervision Testing Therapeutic Time Tissue Sample Tissues Translations Tumor Tissue base biobank cancer stem cell cell free DNA clinical translation experience follow-up improved innovation interest light microscopy neoplastic cell next generation sequencing patient derived xenograft model repository stem cell model therapy outcome transcriptome sequencing transcriptomics translational approach tumor tumor registry

项目摘要

BIOSPECIMEN CORE: SUMMARY The Biospecimen Core is a vital resource that supports all brain tumor research at Northwestern, and is especially important in seeing that all projects experience clinical translation within the period of SPORE funding. Regular interactions with the Biostatistics & Bioinformatics Core and Administrative Core will ensure that each project achieves its objectives, and has positive impact on the care of brain tumor patients. The Biospecimen Core will have extensive interactions with all projects and cores by acting as the central repository of patient tissues and renewable tumor resources, by providing the highest quality of tissue analytical services, and by providing neuropathological consultation. The Director of the Core, Dr. Horbinski, as well as the Co-Director, Dr. Daniel Brat, will supervise quality control testing of banked specimens, and will perform all microscopy-based analyses of patient tissues and tumor models for each SPORE project. Biospecimen Core activities will be performed to accomplish the following aims: Aim 1: Provide Northwestern brain tumor researchers with annotated biospecimens from brain tumor patients. Aim 2: Subject all biospecimens to rigorous quality control. Aim 3: Propagate, bank, and characterize surgical specimen derivatives, including PDX and cancer stem cell (CSC) models, to meet ongoing needs for renewable tumor cell sources. Aim 4: Support SPORE projects with biospecimens and neuropathologic analyses.

生物样本核心：总结生物标本核心是支持西北大学所有脑肿瘤研究的重要资源，尤其重要的是，要确保所有项目都在SPORE期间经历临床翻译经费与生物统计学和生物信息学核心和行政核心的定期互动将确保每个项目都能达到其目标，并对脑肿瘤患者的护理产生积极的影响。生物标本核心将作为中心，与所有项目和核心进行广泛的互动，通过提供最高质量的组织，分析服务，并提供神经病理咨询。核心主任Horbinski博士，作为以及联合主任丹尼尔布拉特博士，将监督库存标本的质量控制测试，并将对每个SPORE项目的患者组织和肿瘤模型进行所有基于显微镜的分析。将开展生物样本核心活动，以实现以下目标：目的1：为西北脑肿瘤研究者提供脑肿瘤的注释生物标本患者目标2：对所有生物标本进行严格的质量控制。目标3：鉴定、储存和表征手术标本衍生物，包括PDX和癌症干细胞（CSC）模型，以满足对可再生肿瘤细胞来源的持续需求。目标4：通过生物标本和神经病理学分析支持SPORE项目。