Administrative Core

项目摘要：罗切斯特大学(UR)IDDRC的行政核心(ADM) 应用程序是一个完全集成的系统的主要协调中心，该系统由四个科学核心组成，支持 105名UR-IDDRC调查人员的关键工作目前起诉了202名基础、翻译和临床 碘缺乏病研究领域的研究项目。这些核心是：人类表型和招募(HPR)； 翻译神经成像与神经生理学(TNN)；细胞与分子成像(CMI)；动物行为 神经生理学(ABN)。ADM核心汇集了IDD领域的两位国际领先者 研究，约翰·福克斯教授和乔纳森·明克教授，都有丰富的互补领导 经验，以协调和起诉这一努力。在与UR-IDDRC社区协商后，他们已经 制定了在IDD研究中卓越的明确和进步的使命，这一使命使我们 为那些有IDD的人服务，IDD是我们中心的核心，是促进公平、包容、多样性和 文化/语言能力。行政管理领导层已经确定了五个主题研究集群，这些集群有助于 将我们的产品组合整合为一个连贯、清晰的IDD计划，我们将围绕该计划建设我们的未来。 它们是：(1)罕见的神经发育孤儿疾病；(2)父母压力和早期生活暴露，如 脑发育的决定因素；(3)病理性脑发育中的神经炎症机制； (4)自闭症谱系障碍；(5)多感觉与感觉运动整合。ADM协调一个 大量试点赠款计划，通过广泛的慈善努力和大量大学提供支持 支持，在一个竞争激烈的计划中每年分发400,000美元，旨在促进高风险、高风险和 退还IDD项目。我们建立了一套创新的事前和事后教育活动制度 博士生，以及大量的传播努力，包括多个在线社交媒体渠道(通过 西班牙语的隐藏字幕和现场活动中的ASL翻译)，这是一项专门设计的工作 供公众消费。ADM协调主要的数据归档和共享工作 与UR CTSI对接，并利用我们最先进的生物实验室信息学系统(BLIS)。 核心已经建立了报告和系统评估，不断审查和评估 中心的运作，确保效率和成本效益保持在最高水平 核心不断演变，以完全响应技术和系统的变化。支持ADM 由五个关键的咨询委员会提供关于该中心持续运作的重要意见。这些 它们是：(A)执行委员会；(B)外部咨询委员会；(C)家长和社区咨询 (D)内部咨询委员会；(E)核心设施管理委员会。我们站在这里 致力于一个清晰的目标，通过我们的科学，我们每天都将努力消除 IDD患者面临的障碍使他们无法尽可能过上最健康、最有成就感的生活。

Project Summary: The Administrative Core (ADM) of this new University of Rochester (UR) IDDRC application serves as the main coordination hub of a fully integrated system of four scientific cores that support the crucial work of 105 UR-IDDRC investigators currently prosecuting 202 basic, translational and clinical research projects in the domain of IDD research. These cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). The ADM Core brings together two international leaders in the field of IDD research, Professors John Foxe and Jonathan Mink, both with a wealth of complementary leadership experience, to coordinate and prosecute this effort. In consultation with the UR-IDDRC community, they have formulated a clear and progressive mission of excellence in IDD research, one that places the people we serve, those with an IDD, at the heart of our Center, and one that promotes equity, inclusion, diversity, and cultural/linguistic competence. The ADM leadership has identified five thematic research clusters that serve to coalesce our portfolio into a coherent well-articulated IDD program, and around which we will build our future. These are: (1) Rare & Orphaned Diseases of Neurodevelopment; (2) Parental Stress & Early Life Exposure as Determinants of Brain Development; (3) Neuroinflammatory Mechanisms in Pathological Brain Development; (4) Autism Spectrum Disorder; and (5) Multisensory & Sensorimotor Integration. The ADM coordinates a substantial pilot grant program, supported through extensive philanthropic efforts and substantial University support, distributing $400,000 per annum in a highly competitive program designed to promote high-risk high- return IDD projects. We have set in place an innovative system of educational activities for pre- and post- doctoral trainees, and a substantial dissemination effort that includes multiple online social media outlets (with closed captioning in Spanish, and ASL translators at live events), an effort that has been specifically designed to be consumable by the public. The ADM coordinates a major data archiving and sharing effort across the Cores, interfacing with the UR CTSI and leveraging our state-of-the-art Bio-Lab Informatics System (BLIS). The Core has established reportage and systematic assessments that continuously scrutinize and evaluate the functioning of the center, ensuring that efficiency and cost-effectiveness are maintained at the highest levels and that the Cores evolve to be fully responsive to changes in technology and systems. The ADM is supported by five key advisory committees that provide crucial input regarding ongoing functioning of the center. These are: (a) The Executive Committee; (b) The External Advisory Board; (c) The Parent and Community Advisory Board; (d) The Internal Advisory Board; and (e) The Core Facilities Management Committee. We stand committed to a clear-eyed purpose, that through our science, we will endeavor each and every day to remove impediments facing people with IDD that prevent them from living the healthiest, most fulfilling lives possible.