University of Rochester Intellectual and Developmental Disabilities Research Center

罗切斯特大学(UR)在提供一流临床服务方面有着悠久而极其丰富的历史 对于智力和发育障碍(IDD)的人，以及通过 为IDD患者创造更多机会充分发挥他们的生活潜力的研究。 这个提议的UR-IDDRC建立在革命性的医学哲学基础上，首先在UR引入 医学中心由教授主持。乔治·恩格尔和乔恩·罗马诺合著的《生物心理社会模型》。这很简单， 然而，深刻的想法是，寻求治疗的人不仅是他们生物学上的产物，而且也是 他们的心理和社会经济环境的混合体，将整个人置于他们所有的 复杂性是医学的中心。如果有一群人值得被认识和对待 在这种整体性的人文主义方式下，是那些患有IDD的人。UR-IDDRC将IDD患者置于中心 ，并致力于在基础、翻译和临床方面提供卓越的服务 研究，专注于为这些人提供易于处理的临床解决方案。在这本书的页面中 项目应用，我们描述了该中心的关键科学基础设施，它支持四个尖端 提升和加速我们105个UR-IDDRC调查人员的工作的核心，提供最新的 高效率、高性价比的现有技术和专业知识。这些核心是： 人类表型和招募(HPR)；翻译神经成像和神经生理学(TNN)；细胞和 分子成像(CMI)；以及动物行为和神经生理学(ABN)。通过强有力的领导和 与我们的UR-IDDRC社区和提供咨询意见的五个主要咨询委员会密切协商 对于我们的管理核心(ADM)，我们阐明了一组五个研究重点，这些重点拥抱了关键并确立了 我们机构的研究优势，同时也寻求将我们的计划扩展到重要的关注领域 给更大的IDD社区。这些疾病是：(1)罕见的神经发育孤儿疾病；(2)父母 应激和早期生活暴露是脑发育的决定因素；(3)神经炎症机制 病理性脑发育；(4)自闭症谱系障碍；(5)多感觉和感觉运动整合。 这一基础设施支持了大约202个正在进行的IDD项目和9个相关的培训赠款， 中心领导层致力于通过吸引和培训新的人才来进一步发展这个已经蓬勃发展的项目。 IDD研究中的年轻研究人员和临床医生。通过以下方式宣传中心工作的主要努力 针对我们社区的媒体渠道和具有文化能力的多语种出版物已经到位。 与我们的IDD社区和广大公众进行接触是UR-IDDRC的核心关注事项。利用 罗切斯特大学领导层对发展UR-IDDRC的巨大财政承诺，以及 通过一个400,000美元的慈善驱动的年度试点赠款基金，城市发展与发展中心领导层处于强有力的地位 在该计划拟议的五年任期内，提出一项创新的、变革性的IDD研究议程。

The University of Rochester (UR) has a long and extraordinarily rich history of providing first-rate clinical services to persons with Intellectual and Developmental Disabilities (IDD), and in driving new discoveries through research that create increased opportunity for individuals with IDD to live their lives to the fullest of their potential. This proposed UR-IDDRC is founded upon a revolutionary philosophy of medicine, first introduced here at UR Medical Center by Profs. George Engel and Jon Romano in 1977: The Biopsychosocial Model. This simple, yet profound idea, that the person seeking treatment is not merely a product of their biology, but rather, is also an amalgam of their psychology and socio-economic circumstances, places the whole person in all their complexity at the center of medicine. If ever there was a population that deserves to be recognized and treated in this holistic humanistic manner, it is those with an IDD. This UR-IDDRC places persons with IDD at the center of our inclusive neurodiverse mission, and commits to providing excellence in our basic, translational and clinical research, with a singular focus on providing tractable clinical solutions for these individuals. In the pages of this program application, we describe the Center’s crucial scientific infrastructure, which supports four cutting-edge Cores that elevate and accelerate the work of our 105 UR-IDDRC investigators, providing the very latest available technologies and expertise with high efficiency and excellent cost-effectiveness. These Cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). Through vigorous leadership and in close consultation with our UR-IDDRC community and the five key advisory committees that provide counsel to our Administrative Core (ADM), we articulate a set of five research foci that embrace key and established research strengths at our institution while also seeking to expand our program into important areas of concern to the larger IDD community. These are: (1) Rare and orphaned diseases of neurodevelopment; (2) Parental stress and early life exposure as determinants of brain development; (3) Neuroinflammatory mechanisms in pathological brain development; (4) Autism spectrum disorder; (5) Multisensory and sensorimotor integration. Some 202 ongoing IDD projects, and 9 associated training grants, are supported by this infrastructure, and the Center Leadership is committed to further growing this already thriving program by attracting and training new young investigators and clinicians in IDD research. Major efforts to disseminate the work of the Center through media outlets and culturally competent multilingual publications, oriented at our community, are in place. Outreach to our IDD community and the public at large is a central concern of the UR-IDDRC. Leveraging the enormous financial commitment of the University of Rochester’s leadership to developing the UR-IDDRC, and through a philanthropy-driven annual pilot grant fund of $400,000, UR-IDDRC leadership is strongly positioned to prosecute an innovative transformative IDD research agenda over the proposed five-year term of this program.