University of Rochester Intellectual and Developmental Disabilities Research Center

罗切斯特大学智力与发育障碍研究中心

• 批准号: 10633122
• 负责人: JOHN J FOXE
• 金额: $ 122.87万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633122
• 关键词: Acceleration; Adopted; Advisory Committees; Affect; Amalgam; Animal Behavior; Architecture; Area; Articulation; Automobile Driving; Basic Science; Biological; Biology; Brain; Caring; Catchment Area; Child; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Collaborations; Communication; Communities; Community Health Education; Community Outreach; Consultations; Counseling; Dedications; Development; Developmental Disabilities; Diagnostic Procedure; Disease; Education and Outreach; Educational workshop; Ensure; Evaluation; Family; Fostering; Funding; Goals; Grant; Health Personnel; Heart; Human; Individual; Infrastructure; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Leadership; Medical; Medical center; Medicine; Mind; Mission; Modeling; Morals; Motion; Multilingualism; Neurosciences; Neurosciences Research; Online Systems; Pathologic; Pathway interactions; Patients; Pediatrics; Persons; Phenotype; Philosophy; Pilot Projects; Population; Positioning Attribute; Program Sustainability; Protocols documentation; Psychology; Publications; Quality Control; Recording of previous events; Research; Research Personnel; Research Project Grants; Scientist; Services; Spielmeyer-Vogt Disease; Strategic Planning; Stress; Support Groups; System; Systems Integration; Talents; Technology; Therapeutic; Training; Translational Research; Universities; Vision; Work; autism spectrum disorder; base; biopsychosocial; cellular imaging; clinical care; clinically actionable; college; cost effectiveness; cultural competence; design; early life exposure; ethnic diversity; expectation; health disparity; innovation; insight; interest; lectures; molecular imaging; multisensory; neurodevelopment; neuroimaging; neuroinflammation; neurophysiology; next generation; novel diagnostics; operation; outreach; prevent; professor; programs; recruit; service programs; socioeconomics; success; translational neuroscience; translational scientist

The University of Rochester (UR) has a long and extraordinarily rich history of providing first-rate clinical services to persons with Intellectual and Developmental Disabilities (IDD), and in driving new discoveries through research that create increased opportunity for individuals with IDD to live their lives to the fullest of their potential. This proposed UR-IDDRC is founded upon a revolutionary philosophy of medicine, first introduced here at UR Medical Center by Profs. George Engel and Jon Romano in 1977: The Biopsychosocial Model. This simple, yet profound idea, that the person seeking treatment is not merely a product of their biology, but rather, is also an amalgam of their psychology and socio-economic circumstances, places the whole person in all their complexity at the center of medicine. If ever there was a population that deserves to be recognized and treated in this holistic humanistic manner, it is those with an IDD. This UR-IDDRC places persons with IDD at the center of our inclusive neurodiverse mission, and commits to providing excellence in our basic, translational and clinical research, with a singular focus on providing tractable clinical solutions for these individuals. In the pages of this program application, we describe the Center’s crucial scientific infrastructure, which supports four cutting-edge Cores that elevate and accelerate the work of our 105 UR-IDDRC investigators, providing the very latest available technologies and expertise with high efficiency and excellent cost-effectiveness. These Cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). Through vigorous leadership and in close consultation with our UR-IDDRC community and the five key advisory committees that provide counsel to our Administrative Core (ADM), we articulate a set of five research foci that embrace key and established research strengths at our institution while also seeking to expand our program into important areas of concern to the larger IDD community. These are: (1) Rare and orphaned diseases of neurodevelopment; (2) Parental stress and early life exposure as determinants of brain development; (3) Neuroinflammatory mechanisms in pathological brain development; (4) Autism spectrum disorder; (5) Multisensory and sensorimotor integration. Some 202 ongoing IDD projects, and 9 associated training grants, are supported by this infrastructure, and the Center Leadership is committed to further growing this already thriving program by attracting and training new young investigators and clinicians in IDD research. Major efforts to disseminate the work of the Center through media outlets and culturally competent multilingual publications, oriented at our community, are in place. Outreach to our IDD community and the public at large is a central concern of the UR-IDDRC. Leveraging the enormous financial commitment of the University of Rochester’s leadership to developing the UR-IDDRC, and through a philanthropy-driven annual pilot grant fund of $400,000, UR-IDDRC leadership is strongly positioned to prosecute an innovative transformative IDD research agenda over the proposed five-year term of this program.

罗切斯特大学（UR）在提供一流的临床服务方面有着悠久而非凡的丰富历史

项目成果

Neural Markers of Auditory Response and Habituation in Phelan-McDermid Syndrome.

• DOI: 10.3389/fnins.2022.815933
• 发表时间: 2022
• 期刊: FRONTIERS IN NEUROSCIENCE
• 影响因子: 4.3
• 作者: Isenstein, Emily L.;Grosman, Hannah E.;Guillory, Sylvia B.;Zhang, Yian;Barkley, Sarah;McLaughlin, Christopher S.;Levy, Tess;Halpern, Danielle;Siper, Paige M.;Buxbaum, Joseph D.;Kolevzon, Alexander;Foss-Feig, Jennifer H.
• 通讯作者: Foss-Feig, Jennifer H.

Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9-10 year old children.

子宫内摄入咖啡因与 9-10 岁儿童的大脑结构改变和有害的神经认知结果有关。

• DOI: 10.1016/j.neuropharm.2021.108479
• 发表时间: 2021-03-15
• 期刊: Neuropharmacology
• 影响因子: 4.7
• 作者: Christensen ZP;Freedman EG;Foxe JJ
• 通讯作者: Foxe JJ

Network size affects the complexity of activity in human iPSC-derived neuronal populations.

网络大小影响人类 iPSC 衍生神经元群体活动的复杂性。

• DOI: 10.1101/2023.10.31.564939
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Uzun,YavuzSelim;Santos,Renata;Marchetto,MariaC;Padmanabhan,Krishnan
• 通讯作者: Padmanabhan,Krishnan

Event-related potential (ERP) evidence for visual processing differences in children and adults with cystinosis (CTNS gene mutations).

• DOI: 10.1186/s13023-023-02985-y
• 发表时间: 2023-12-12
• 期刊: Orphanet journal of rare diseases
• 影响因子: 3.7

A Model-Based Hierarchical Bayesian Approach to Sholl Analysis.

基于模型的 Sholl 分析的分层贝叶斯方法。

• DOI: 10.1101/2023.01.23.525256
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Vonkaenel,Erik;Feidler,Alexis;Lowery,Rebecca;Andersh,Katherine;Love,Tanzy;Majewska,Ania;McCall,MatthewN
• 通讯作者: McCall,MatthewN