Administrative Core

项目概要：罗切斯特大学（UR）IDDRC的行政核心（ADM） 应用程序是一个完全集成的系统的主要协调中心，该系统由四个科学核心组成， 105名UR-IDDRC调查人员的关键工作，目前起诉202名基础，翻译和临床 碘缺乏病研究领域的研究项目。这些核心是：人类表型和招募（HPR）; 转化神经影像学和神经生理学（TNN）;细胞和分子成像（CMI）;和动物行为 神经生理学（ABN）ADM核心汇集了IDD领域的两个国际领导者 研究，教授约翰福克斯和乔纳森明克，都具有丰富的互补领导 经验，以协调和起诉这一努力。在与UR-IDDRC社区协商后，他们 制定了一个明确的和渐进的使命卓越的缺碘症研究，一个地方的人，我们 服务，那些与IDD，在我们的中心的核心，一个促进公平，包容，多样性， 文化/语言能力。ADM领导层确定了五个专题研究集群， 将我们的业务组合整合成一个连贯的、清晰的IDD计划，我们将围绕这个计划建设我们的未来。 这些是：（1）罕见和孤儿神经发育疾病;（2）父母压力和早期生活暴露， 脑发育的决定因素;（3）病理性脑发育中的神经炎症机制; (4)自闭症谱系障碍;（5）多感觉和感觉运动整合。ADM协调a 大量的试点赠款计划，通过广泛的慈善努力和大量的大学支持， 支持，每年在一个高度竞争的计划中分配40万美元，该计划旨在促进高风险的高风险， 返回IDD项目。我们已经建立了一个创新的教育活动系统， 博士生，以及大量的传播工作，包括多个在线社交媒体渠道（与 西班牙语的隐藏字幕，以及现场活动中的ASL翻译），这是一项专门设计的工作， 供大众消费。ADM负责协调整个 核心，与UR CTSI接口，并利用我们最先进的生物实验室信息系统（BLIS）。 核心组织建立了报告文学和系统评估，不断审查和评估 中心的运作，确保效率和成本效益保持在最高水平 核心的发展能够充分响应技术和系统的变化。ADM支持 五个主要咨询委员会就中心的持续运作提供关键投入。这些 （a）执行委员会;（B）外部咨询委员会;（c）家长和社区咨询委员会 （d）内部咨询委员会;（e）核心设施管理委员会。我们站 致力于一个明确的目标，通过我们的科学，我们将奋进每一天，以消除 缺碘症患者所面临的障碍，使他们无法过上最健康、最充实的生活。

Project Summary: The Administrative Core (ADM) of this new University of Rochester (UR) IDDRC application serves as the main coordination hub of a fully integrated system of four scientific cores that support the crucial work of 105 UR-IDDRC investigators currently prosecuting 202 basic, translational and clinical research projects in the domain of IDD research. These cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). The ADM Core brings together two international leaders in the field of IDD research, Professors John Foxe and Jonathan Mink, both with a wealth of complementary leadership experience, to coordinate and prosecute this effort. In consultation with the UR-IDDRC community, they have formulated a clear and progressive mission of excellence in IDD research, one that places the people we serve, those with an IDD, at the heart of our Center, and one that promotes equity, inclusion, diversity, and cultural/linguistic competence. The ADM leadership has identified five thematic research clusters that serve to coalesce our portfolio into a coherent well-articulated IDD program, and around which we will build our future. These are: (1) Rare & Orphaned Diseases of Neurodevelopment; (2) Parental Stress & Early Life Exposure as Determinants of Brain Development; (3) Neuroinflammatory Mechanisms in Pathological Brain Development; (4) Autism Spectrum Disorder; and (5) Multisensory & Sensorimotor Integration. The ADM coordinates a substantial pilot grant program, supported through extensive philanthropic efforts and substantial University support, distributing $400,000 per annum in a highly competitive program designed to promote high-risk high- return IDD projects. We have set in place an innovative system of educational activities for pre- and post- doctoral trainees, and a substantial dissemination effort that includes multiple online social media outlets (with closed captioning in Spanish, and ASL translators at live events), an effort that has been specifically designed to be consumable by the public. The ADM coordinates a major data archiving and sharing effort across the Cores, interfacing with the UR CTSI and leveraging our state-of-the-art Bio-Lab Informatics System (BLIS). The Core has established reportage and systematic assessments that continuously scrutinize and evaluate the functioning of the center, ensuring that efficiency and cost-effectiveness are maintained at the highest levels and that the Cores evolve to be fully responsive to changes in technology and systems. The ADM is supported by five key advisory committees that provide crucial input regarding ongoing functioning of the center. These are: (a) The Executive Committee; (b) The External Advisory Board; (c) The Parent and Community Advisory Board; (d) The Internal Advisory Board; and (e) The Core Facilities Management Committee. We stand committed to a clear-eyed purpose, that through our science, we will endeavor each and every day to remove impediments facing people with IDD that prevent them from living the healthiest, most fulfilling lives possible.