University of Rochester Intellectual and Developmental Disabilities Research Center

罗切斯特大学智力与发育障碍研究中心

• 批准号: 10085498
• 负责人: JOHN J FOXE
• 金额: $ 122.87万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10085498
• 关键词: Adopted; Advisory Committees; Affect; Amalgam; Animal Behavior; Architecture; Area; Automobile Driving; Basic Science; Biological; Biology; Brain; Caring; Catchment Area; Child; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Collaborations; Communication; Communities; Community Outreach; Consultations; Counseling; Development; Developmental Disabilities; Diagnostic Procedure; Disease; Education and Outreach; Educational workshop; Ensure; Evaluation; Family; Fostering; Fruit; Funding; Goals; Grant; Health Personnel; Heart; Human; Individual; Infrastructure; Institutes; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Lead; Leadership; Medical; Medical center; Medicine; Mind; Mission; Modeling; Morals; Motion; Multilingualism; Neurosciences; Neurosciences Research; Online Systems; Pathologic; Pathway interactions; Patients; Pediatrics; Persons; Phenotype; Philosophy; Pilot Projects; Population; Positioning Attribute; Program Sustainability; Protocols documentation; Psychology; Publications; Quality Control; Rare Diseases; Recording of previous events; Research; Research Personnel; Research Project Grants; Scientist; Services; Spielmeyer-Vogt Disease; Strategic Planning; Stress; Support Groups; System; Talents; Technology; Therapeutic; Training; Translational Research; Universities; Vision; Work; autism spectrum disorder; base; biopsychosocial; cellular imaging; clinical care; clinically actionable; college; cost effectiveness; design; early life exposure; early life stress; ethnic diversity; expectation; health disparity; innovation; insight; interest; lectures; molecular imaging; multisensory; neurodevelopment; neuroimaging; neuroinflammation; neurophysiology; next generation; novel diagnostics; operation; outreach; prevent; professor; programs; recruit; service programs; socioeconomics; success; translational neuroscience; translational scientist

The University of Rochester (UR) has a long and extraordinarily rich history of providing first-rate clinical services to persons with Intellectual and Developmental Disabilities (IDD), and in driving new discoveries through research that create increased opportunity for individuals with IDD to live their lives to the fullest of their potential. This proposed UR-IDDRC is founded upon a revolutionary philosophy of medicine, first introduced here at UR Medical Center by Profs. George Engel and Jon Romano in 1977: The Biopsychosocial Model. This simple, yet profound idea, that the person seeking treatment is not merely a product of their biology, but rather, is also an amalgam of their psychology and socio-economic circumstances, places the whole person in all their complexity at the center of medicine. If ever there was a population that deserves to be recognized and treated in this holistic humanistic manner, it is those with an IDD. This UR-IDDRC places persons with IDD at the center of our inclusive neurodiverse mission, and commits to providing excellence in our basic, translational and clinical research, with a singular focus on providing tractable clinical solutions for these individuals. In the pages of this program application, we describe the Center’s crucial scientific infrastructure, which supports four cutting-edge Cores that elevate and accelerate the work of our 105 UR-IDDRC investigators, providing the very latest available technologies and expertise with high efficiency and excellent cost-effectiveness. These Cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). Through vigorous leadership and in close consultation with our UR-IDDRC community and the five key advisory committees that provide counsel to our Administrative Core (ADM), we articulate a set of five research foci that embrace key and established research strengths at our institution while also seeking to expand our program into important areas of concern to the larger IDD community. These are: (1) Rare and orphaned diseases of neurodevelopment; (2) Parental stress and early life exposure as determinants of brain development; (3) Neuroinflammatory mechanisms in pathological brain development; (4) Autism spectrum disorder; (5) Multisensory and sensorimotor integration. Some 202 ongoing IDD projects, and 9 associated training grants, are supported by this infrastructure, and the Center Leadership is committed to further growing this already thriving program by attracting and training new young investigators and clinicians in IDD research. Major efforts to disseminate the work of the Center through media outlets and culturally competent multilingual publications, oriented at our community, are in place. Outreach to our IDD community and the public at large is a central concern of the UR-IDDRC. Leveraging the enormous financial commitment of the University of Rochester’s leadership to developing the UR-IDDRC, and through a philanthropy-driven annual pilot grant fund of $400,000, UR-IDDRC leadership is strongly positioned to prosecute an innovative transformative IDD research agenda over the proposed five-year term of this program.

罗切斯特大学 (UR) 在提供一流的临床服务方面拥有悠久而丰富的历史 为智力和发育障碍 (IDD) 人士提供帮助，并通过以下方式推动新发现 研究为 IDD 患者创造更多机会，让他们充分发挥自己的潜力。 UR-IDDRC 提案建立在革命性的医学哲学之上，首次在 UR 引入 教授的医疗中心。乔治·恩格尔和乔恩·罗马诺，1977 年：生物心理社会模型。这个简单的， 然而深刻的想法是，寻求治疗的人不仅仅是其生物学的产物，而且也是 他们的心理和社会经济环境的结合，使整个人处于他们所有的状态 医学中心的复杂性。如果有一个群体值得被认可和对待 以这种整体人文主义的方式，它是那些具有 IDD 的人。该 UR-IDDDRC 将 IDD 患者置于中心位置 我们的包容性神经多样性使命，并致力于在我们的基础、转化和临床方面提供卓越的服务 研究，重点是为这些人提供易于处理的临床解决方案。在本页中 在项目申请中，我们描述了该中心的关键科学基础设施，它支持四个尖端 提升和加速我们 105 名 UR-IDDRC 研究人员工作的核心，提供最新的 现有的技术和专业知识具有高效率和卓越的成本效益。这些核心是： 人类表型分析和招募（HPR）；转化神经影像学和神经生理学（TNN）；细胞 ＆ 分子成像（CMI）；以及动物行为和神经生理学（ABN）。通过强有力的领导和 与我们的 UR-IDDRC 社区以及提供咨询的五个主要咨询委员会密切协商 在我们的行政核心（ADM）中，我们阐明了一组五个研究重点，其中包括关键和既定的研究重点 我们机构的研究优势，同时也寻求将我们的项目扩展到重要的关注领域 到更大的 IDD 社区。这些是： (1) 神经发育的罕见和孤儿疾病； (2) 家长 压力和早期生活暴露是大脑发育的决定因素； (3)神经炎症机制 病理性大脑发育； (4) 自闭症谱系障碍； (5)多感觉和感觉运动整合。 该基础设施支持约 202 个正在进行的 IDD 项目以及 9 项相关培训补助金 中心领导层致力于通过吸引和培训新人来进一步发展这个已经蓬勃发展的项目 IDD 研究中的年轻研究者和临床医生。通过以下方式传播中心工作的主要努力： 面向我们社区的媒体机构和具有文化能力的多语言出版物已经到位。 UR-IDDRC 的核心关注点是向我们的 IDD 社区和广大公众进行宣传。利用 罗切斯特大学领导层对发展 UR-IDDRC 的巨额财政承诺，以及 通过由慈善事业驱动的 400,000 美元年度试点拨款基金，UR-IDDDRC 的领导地位处于有利地位 在该计划拟议的五年期限内实施创新的变革性 IDD 研究议程。