University of Rochester Intellectual and Developmental Disabilities Research Center

罗切斯特大学智力与发育障碍研究中心

• 批准号: 10445279
• 负责人: JOHN J FOXE
• 金额: $ 122.87万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445279
• 关键词: Adopted; Advisory Committees; Affect; Amalgam; Animal Behavior; Architecture; Area; Automobile Driving; Basic Science; Biological; Biology; Brain; Caring; Catchment Area; Child; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Collaborations; Communication; Communities; Community Outreach; Consultations; Counseling; Development; Developmental Disabilities; Diagnostic Procedure; Disease; Education and Outreach; Educational workshop; Ensure; Evaluation; Family; Fostering; Fruit; Funding; Goals; Grant; Health Personnel; Heart; Human; Individual; Infrastructure; Institutes; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Lead; Leadership; Medical; Medical center; Medicine; Mind; Mission; Modeling; Morals; Motion; Multilingualism; Neurosciences; Neurosciences Research; Online Systems; Pathologic; Pathway interactions; Patients; Pediatrics; Persons; Phenotype; Philosophy; Pilot Projects; Population; Positioning Attribute; Program Sustainability; Protocols documentation; Psychology; Publications; Quality Control; Rare Diseases; Recording of previous events; Research; Research Personnel; Research Project Grants; Scientist; Services; Spielmeyer-Vogt Disease; Strategic Planning; Stress; Support Groups; System; Talents; Technology; Therapeutic; Training; Translational Research; Universities; Vision; Work; autism spectrum disorder; base; biopsychosocial; cellular imaging; clinical care; clinically actionable; college; cost effectiveness; cultural competence; design; early life exposure; early life stress; ethnic diversity; expectation; health disparity; innovation; insight; interest; lectures; molecular imaging; multisensory; neurodevelopment; neuroimaging; neuroinflammation; neurophysiology; next generation; novel diagnostics; operation; outreach; prevent; professor; programs; recruit; service programs; socioeconomics; success; translational neuroscience; translational scientist

The University of Rochester (UR) has a long and extraordinarily rich history of providing first-rate clinical services to persons with Intellectual and Developmental Disabilities (IDD), and in driving new discoveries through research that create increased opportunity for individuals with IDD to live their lives to the fullest of their potential. This proposed UR-IDDRC is founded upon a revolutionary philosophy of medicine, first introduced here at UR Medical Center by Profs. George Engel and Jon Romano in 1977: The Biopsychosocial Model. This simple, yet profound idea, that the person seeking treatment is not merely a product of their biology, but rather, is also an amalgam of their psychology and socio-economic circumstances, places the whole person in all their complexity at the center of medicine. If ever there was a population that deserves to be recognized and treated in this holistic humanistic manner, it is those with an IDD. This UR-IDDRC places persons with IDD at the center of our inclusive neurodiverse mission, and commits to providing excellence in our basic, translational and clinical research, with a singular focus on providing tractable clinical solutions for these individuals. In the pages of this program application, we describe the Center’s crucial scientific infrastructure, which supports four cutting-edge Cores that elevate and accelerate the work of our 105 UR-IDDRC investigators, providing the very latest available technologies and expertise with high efficiency and excellent cost-effectiveness. These Cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). Through vigorous leadership and in close consultation with our UR-IDDRC community and the five key advisory committees that provide counsel to our Administrative Core (ADM), we articulate a set of five research foci that embrace key and established research strengths at our institution while also seeking to expand our program into important areas of concern to the larger IDD community. These are: (1) Rare and orphaned diseases of neurodevelopment; (2) Parental stress and early life exposure as determinants of brain development; (3) Neuroinflammatory mechanisms in pathological brain development; (4) Autism spectrum disorder; (5) Multisensory and sensorimotor integration. Some 202 ongoing IDD projects, and 9 associated training grants, are supported by this infrastructure, and the Center Leadership is committed to further growing this already thriving program by attracting and training new young investigators and clinicians in IDD research. Major efforts to disseminate the work of the Center through media outlets and culturally competent multilingual publications, oriented at our community, are in place. Outreach to our IDD community and the public at large is a central concern of the UR-IDDRC. Leveraging the enormous financial commitment of the University of Rochester’s leadership to developing the UR-IDDRC, and through a philanthropy-driven annual pilot grant fund of $400,000, UR-IDDRC leadership is strongly positioned to prosecute an innovative transformative IDD research agenda over the proposed five-year term of this program.

罗切斯特大学（UR）在提供一流的临床服务方面有着悠久而丰富的历史 智力和发育障碍（IDD）的人，并推动新发现， 研究为缺碘症患者创造更多的机会，使他们的生活最大限度地发挥其潜力。 这个建议UR-IDDRC是建立在一个革命性的医学哲学，首先介绍了在这里UR 医学中心教授乔治恩格尔和乔恩罗马诺在1977年：生物心理社会模型。这个简单的， 然而深刻的想法是，寻求治疗的人不仅仅是其生物学的产物，而且也是 他们的心理和社会经济环境的混合物，将整个人置于他们所有的 复杂性是医学的核心。如果有一群人值得被承认和对待 在这种整体的人文主义的态度下，它是那些患有IDD的人。该UR-IDDRC将IDD患者置于中心位置 我们的包容性神经多样性的使命，并致力于提供卓越的基础，翻译和临床 研究，专注于为这些人提供易于处理的临床解决方案。在这本书中， 计划的应用，我们描述了该中心的重要科学基础设施，它支持四个尖端 提升和加速我们105名UR-IDDRC调查人员的工作，提供最新的 利用现有的技术和专业知识，高效率和高成本效益。这些核心是： 人类表型和招募（HPR）;转化神经影像学和神经生理学（TNN）;细胞和 分子成像（CMI）;和动物行为和神经生理学（ABN）。通过强有力的领导和 与我们的UR-IDDRC社区和提供咨询的五个关键咨询委员会密切协商， 我们的行政核心（ADM），我们阐明了一套五个研究重点，包括关键和建立 在我们机构的研究优势，同时也寻求扩大我们的计划到关注的重要领域 更大的IDD社区。这些是：（1）罕见和孤儿神经发育疾病;（2）父母 压力和早期生活暴露作为大脑发育的决定因素;（3） 病理性脑发育;（4）自闭症谱系障碍;（5）多感觉和感觉运动整合。 大约202个正在进行的缺碘症项目和9个相关的培训赠款得到了这一基础设施的支助， 中心领导致力于进一步发展这个已经蓬勃发展的计划，吸引和培训新的 年轻的研究人员和临床医生在碘缺乏病研究。通过以下方式传播中心工作的重大努力 已经建立了面向我们社区的媒体渠道和具有文化能力的多语种出版物。 与我们的IDD社区和广大公众的联系是UR-IDDRC的核心关注点。借力 罗切斯特大学领导层对开发UR-IDDRC的巨大财政承诺，以及 通过每年40万美元的由慈善机构推动的试点赠款基金，乌干达大学-非洲发展研究中心的领导层处于有利地位 在该计划拟议的五年期内，执行一项创新的、变革性的缺碘症研究议程。