Module 1: Visual Function Assessment

视觉功能评估模块允许对眼睛结构和功能进行非侵入性评估，这是 对于使用动物模型的视觉系统的临床相关研究至关重要。它为调查人员提供了 系统地询问正常的视觉功能及其对视觉的影响所需的工具 正常的流程会出错。本模块中提供的专业知识和工具超出了 单独调查人员的实验室，并提供访问设备的机会，如果由一名调查人员购买， 会迅速耗尽宝贵的资源。该模块提供熟练的专业知识、培训和必要的状态- 进行以下评估的最先进的设备：(1)视网膜电图(ERG)，(2)视动 跟踪响应(OKR)，(3)光谱域光学相干断层扫描(OCT)，(4)眼底检查，(5) 荧光素血管造影术(FA)，(6)裂隙灯生物显微镜，(7)眼压。对于ERG，模块 提供高技能的博士电生理学家的专业知识，他可以执行复杂的视网膜功能 它还为调查人员提供执行常规ERG的培训。一位博士级别的科学家执导 并为实验室人员提供其他评估(OCT、FA、OKR等)的培训。 本模块中提供的仪器包括Celeris完全集成的高通量ERG测试系统， 菲尼克斯微米甘兹菲尔德ERG，生物光谱域眼科成像系统(ENVISU R2200)、图像导引Micron IV OCT、二凤凰Micron IV活体高分辨率视网膜成像 用于眼底检查和眼底检查的显微镜，Topcon SL-DR裂隙灯和两个用于快速眼压的手持式眼压计 评估。这些仪器已被许多卡尔弗VDI调查人员广泛使用，导致 协作和共享出版物/演示文稿，充分证明将这些服务正式化为一个模块是合理的。 该设备的使用将加强NEI调查人员的视力研究，这是NEI R01的首次 研究人员和视觉研究领域的新手科学家。核心的活动将通过以下方式实现 以下目标：目标1.为核心研究人员提供最先进的活体视觉仪器 视觉系统的功能分析和活体成像。目标2.提供专家技术援助和 培训模块内共享仪器的使用。目标3.维护模块插装 良好的工作条件，以促进工作效率、协作和 开发解决威胁视力的重大疾病的新项目。

The visual function assessment module allows non-invasive assessment of eye structure and function, which is critical for clinically-relevant studies of the visual system employing animal models. It affords investigators the tools necessary to systematically interrogate normal visual function and the consequences on vision when normal processes go awry. The expertise and instrumentation available in this module exceed resources of individual investigators’ laboratories and provide access to equipment that, if purchased by a single investigator, would rapidly deplete precious resources. The module provides skilled expertise, training and essential, state- of-the-art equipment to perform the following assessments: (1) electroretinography (ERG), (2) optokinetic tracking response (OKR), (3) spectral domain optical coherence tomography (OCT), (4) fundoscopy, (5) fluorescein angiography (FA), (6) slit-lamp biomicroscopy, (7) intraocular pressure (IOP). For ERGs, the module offers the expertise of a highly skilled PhD electrophysiologist who can perform sophisticated retinal function evaluation and it also offers training for investigators in execution of routine ERGs. A PhD level scientist directs the module and provides training for laboratory personnel for other assessments (OCT, FA, OKR etc). Instruments available in this module include the Celeris Fully Integrated High Throughput ERG Testing system, the Phoenix MICRON Ganzfield ERG, the Bioptigen Spectral Domain Ophthalmic Imaging System (Envisu R2200), the image-guided MICRON IV OCT, two Phoenix MICRON IV in vivo high-resolution retinal imaging microscopes for FA and fundoscopy, the Topcon SL-DR slit-lamp and two hand-held tonometers for rapid IOP assessment. These instruments have been widely used by a number of Culver VDI investigators resulting in collaborations and shared publications/presentations that fully justify formalizing these services as a module. Access to this equipment will enhance vision research for established NEI investigators, first-time NEI R01 investigators, and scientists new to the field of vision research. The activities of the core will be achieved through the following aims: Aim 1. Provide core investigators access to state-of-the-art instrumentation for in vivo visual function analysis and in vivo imaging of the visual system. Aim 2. Provide expert technical assistance and training in the use of the shared instrumentation within the module. Aim 3. Maintain module instrumentation in good working condition, manage usage in a manner that will facilitate productivity, collaboration and the development of novel projects that address major sight-threatening diseases.