Module 1: Visual Function Assessment

模块 1：视觉功能评估

• 批准号: 10470148
• 负责人: Sylvia B. Smith
• 金额: $ 19.94万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470148
• 关键词: Address; Age related macular degeneration; Animal Experimentation; Animal Model; Architecture; Center Core Grants; Collaborations; Corneal dystrophy; Development; Diabetic Retinopathy; Disease; Doctor of Philosophy; Electroretinography; Equipment; Evaluation; Eye; Fluorescein Angiography; Funding; Future; Glaucoma; Goals; Hand; Human; Individual; Intervention; Laboratories; Laboratory Personnel; Optical Coherence Tomography; Outcome; Patients; Physiologic Intraocular Pressure; Process; Productivity; Publications; Research Personnel; Research Project Grants; Resolution; Resources; Retina; Retinitis Pigmentosa; Scientist; Services; Structure; System; Testing; Time; Training; Treatment outcome; Vision; Vision research; Visual system structure; clinically relevant; disease natural history; equipment acquisition; image guided; imaging system; in vivo; in vivo imaging; instrument; instrumentation; investigator training; laboratory experience; member; microscopic imaging; novel; response; retinal imaging; slit lamp imaging; tool

The visual function assessment module allows non-invasive assessment of eye structure and function, which is critical for clinically-relevant studies of the visual system employing animal models. It affords investigators the tools necessary to systematically interrogate normal visual function and the consequences on vision when normal processes go awry. The expertise and instrumentation available in this module exceed resources of individual investigators’ laboratories and provide access to equipment that, if purchased by a single investigator, would rapidly deplete precious resources. The module provides skilled expertise, training and essential, state- of-the-art equipment to perform the following assessments: (1) electroretinography (ERG), (2) optokinetic tracking response (OKR), (3) spectral domain optical coherence tomography (OCT), (4) fundoscopy, (5) fluorescein angiography (FA), (6) slit-lamp biomicroscopy, (7) intraocular pressure (IOP). For ERGs, the module offers the expertise of a highly skilled PhD electrophysiologist who can perform sophisticated retinal function evaluation and it also offers training for investigators in execution of routine ERGs. A PhD level scientist directs the module and provides training for laboratory personnel for other assessments (OCT, FA, OKR etc). Instruments available in this module include the Celeris Fully Integrated High Throughput ERG Testing system, the Phoenix MICRON Ganzfield ERG, the Bioptigen Spectral Domain Ophthalmic Imaging System (Envisu R2200), the image-guided MICRON IV OCT, two Phoenix MICRON IV in vivo high-resolution retinal imaging microscopes for FA and fundoscopy, the Topcon SL-DR slit-lamp and two hand-held tonometers for rapid IOP assessment. These instruments have been widely used by a number of Culver VDI investigators resulting in collaborations and shared publications/presentations that fully justify formalizing these services as a module. Access to this equipment will enhance vision research for established NEI investigators, first-time NEI R01 investigators, and scientists new to the field of vision research. The activities of the core will be achieved through the following aims: Aim 1. Provide core investigators access to state-of-the-art instrumentation for in vivo visual function analysis and in vivo imaging of the visual system. Aim 2. Provide expert technical assistance and training in the use of the shared instrumentation within the module. Aim 3. Maintain module instrumentation in good working condition, manage usage in a manner that will facilitate productivity, collaboration and the development of novel projects that address major sight-threatening diseases.

视觉功能评估模块允许对眼睛结构和功能进行非侵入性评估， 这对于采用动物模型的视觉系统的临床相关研究至关重要。它为调查人员提供了 必要的工具，系统地询问正常的视觉功能和视力的后果时， 正常的程序就会出错本模块中提供的专业知识和工具超过了 研究人员的实验室，并提供使用设备的机会，如果由一名研究人员购买， 会迅速耗尽宝贵的资源该模块提供熟练的专业知识，培训和必要的，状态- 最先进的设备进行以下评估：（1）视网膜电图（ERG），（2）视动 跟踪响应（OKR），（3）谱域光学相干断层扫描（OCT），（4）眼底镜检查，（5） 荧光素血管造影（FA）;（6）裂隙灯生物显微镜检查;（7）眼内压（IOP）。对于ERG，模块 提供了一个高度熟练的电生理学博士的专业知识，他可以执行复杂的视网膜功能， 它还为研究者提供执行常规ERG的培训。一位博士水平的科学家指导 该模块并为实验室人员提供其他评估（OCT、FA、OKR等）的培训。 该模块中提供的仪器包括全集成高分辨率ERG测试系统， Phoenix MICRON Ganzfield ERG、Bioptigen光谱域眼科成像系统（Envisu R2200）、图像引导MICRON IV OCT、两台Phoenix MICRON IV体内高分辨率视网膜成像 用于FA和眼底镜检查的显微镜，Topcon SL-DR裂隙灯和两个用于快速IOP的手持式眼压计 考核这些仪器已被广泛使用的一些卡尔弗研究人员， 合作和共享出版物/演示文稿，充分证明将这些服务正式定为一个模块是合理的。 获得这种设备将加强对NEI研究人员的视觉研究，首次NEI R 01 研究人员和科学家新的视觉研究领域。核心的活动将通过以下方式实现： 目标：目标1。为核心研究者提供最先进的仪器，以进行体内目视检查 视觉系统的功能分析和体内成像。目标2.提供专家技术援助， 培训如何使用模块内的共享仪器。目标3。维护模块仪表， 良好的工作条件，管理使用的方式，将促进生产力，协作和 开发解决主要威胁视力疾病的新项目。