Computational/Biostatistical Core

计算/生物统计核心

• 批准号: 10227728
• 负责人: Olivier Elemento
• 金额: $ 21.51万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-30 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227728
• 关键词: Alleles; Area; Award; Benchmarking; Biometry; Biostatistics Core; Cancer Model; ChIP-seq; Chromatin; Clinical; Clinical Trials Design; Clonality; Collaborations; Computational Biology; Computer Analysis; Computer Vision Systems; Custom; DNA Methylation; DNA analysis; DNA sequencing; Data Set; Detection; Development; Early Detection Research Network; Encyclopedia of DNA Elements; Gene Expression Profiling; Genome; Genome Data Analysis Network; Genomic DNA; Genomics; Grant; Heterogeneity; Hi-C; Hospitals; Image Analysis; Institutes; International; Malignant neoplasm of prostate; Medicine; Methodology; Methods; Methylation; Mutation; New York; Pathway interactions; Pharmaceutical Preparations; Phase; Pilot Projects; Presbyterian Church; Publications; Publishing; Quality Control; Research; Research Personnel; Resources; Sampling; Scientist; Services; Signal Pathway; Techniques; The Cancer Genome Atlas; bisulfite sequencing; cancer genome; computational pipelines; computer infrastructure; computerized tools; data centers; data sharing; design; epigenomics; experience; experimental study; genomic data; mathematical model; member; metabolomics; novel; novel strategies; precision medicine; statistical service; synergism; tool; transcriptome sequencing; tumor

COMPUTATIONAL BIOLOGY AND BIOSTATISTICS CORE SUMMARY The Computational Biology and Biostatistics Core (CBBC) will provide essential computational and biostatistical services and resources for all projects of the WCM SPORE in Prostate Cancer (PCa). Analytic services include statistical design and analysis, extensive quality control, integrative analysis and interpretation of genomic (DNA-seq, RNA-seq) epigenomic (ChIP-seq, bisulfite sequencing) datasets and implementation and development of custom computational pipelines needed by the projects. Core investigators include Drs Elemento and Ballman (Co-Directors), Dr Sboner (Co-investigator) and Dr Demichelis (Co-investigator). All CBBC investigators are highly experienced scientists with an extensive track record of publications and grants in their field and have authored first, last or co-author publications in prostate cancer. CBBC investigators have developed key computational biology methods ranging from pathway and motif analysis (iPAGE and FIRE) to fusion detection (FusionSeq) and tumor and mutational clonality analysis (CLONET). In addition to analytic services, the Computational Biology and Biostatistics Core will provide centralized access to a number of computational tools developed by the core investigators as well as direct access to expertise for the design and analysis of genomic and epigenomic experiments. The Computational Biology and Biostatistics Core will take advantage of the shared computational infrastructure of the Institute for Computational Biomedicine (ICB) at Weill Cornell Medicine (WCM) and of clinical-grade computational pipelines already developed in the context of the WCM/NewYork-Presbyterian Hospital (NYPH) Englander Institute for Precision Medicine (IPM). Specifically, CBBC will provide computational analysis of genomic, epigenomic, and transcriptional profiling for all Projects and Cores that are part of this SPORE (Aim 1). CBBC will also provide the full spectrum of statistical services for all Projects and Cores that are part of the SPORE (Aim 2). Project 1 (co-led by Dr Beltran and Demichelis), Project 2 (co-led by Drs Rickman and Beltran), Project 3 (co-led by Drs. Rubin, Tomlins, and Shen) and Project 4 (co-led by Dr. Barbieri and Shen) will all use the CBBC. In addition, CBBC will support DRP and CEP projects as they develop.

预防生物学和生物统计学核心摘要 计算生物学和生物统计学核心（CBBC）将提供必要的计算和 为WCM SPORE在前列腺癌（PCa）中的所有项目提供生物统计服务和资源。解析 服务包括统计设计和分析、广泛的质量控制、综合分析和解释 基因组（DNA-seq，RNA-seq）表观基因组（ChIP-seq，亚硫酸氢盐测序）数据集和实施 以及开发项目所需的自定义计算管道。核心调查人员包括博士 Elemento和Ballman（联合主任）、Sponer博士（联合研究者）和Demichelis博士（联合研究者）。所有 牛熊证调查员是经验丰富的科学家，拥有丰富的出版物和赠款记录 在他们的领域，并撰写了前列腺癌的第一，最后或共同作者的出版物。CBBC调查人员 开发了关键的计算生物学方法，从途径和基序分析（iPAGE和FIRE）到 融合检测（FusionSeq）和肿瘤和突变克隆性分析（CLONET）。除了分析 服务，计算生物学和生物统计学核心将提供集中访问一些 核心研究人员开发的计算工具以及直接获得设计专业知识 以及基因组和表观基因组实验的分析。计算生物学和生物统计学核心将 利用计算生物医学研究所（ICB）的共享计算基础设施 在威尔康奈尔医学（WCM）和临床级计算管道已经开发的背景下， WCM/纽约长老会医院（NYPH）英格兰德精密医学研究所（IPM）。 具体来说，CBBC将提供基因组，表观基因组和转录谱的计算分析， 属于此SPORE（目标1）一部分的所有项目和核心。牛熊证亦会提供全面的 为所有属于SPORE（目标2）的项目和核心提供统计服务。项目1（由Dr Beltran和Demichelis），项目2（由Rickman博士和Beltran博士共同领导），项目3（由Rubin博士共同领导， Tomlins博士及沈博士共同领导）及项目4（由Barbieri博士及沈博士共同领导）将全部使用牛熊证。此外，CBBC 将支持DRP和CEP项目的发展。