Computational/Biostatistical Core

计算生物学与生物统计学核心综述 计算生物学和生物统计核心(CBBC)将提供基本的计算和 前列腺癌WCM孢子(PCA)所有项目的生物统计服务和资源。分析 服务包括统计设计和分析、广泛的质量控制、综合分析和解释 基因组(DNA-SEQ、RNA-SEQ)表观基因组(CHIP-SEQ、亚硫酸氢盐测序)数据集及其实现 以及开发项目所需的定制计算管道。核心调查人员包括DRS Elemento和Ballman(联合主任)、Sboner博士(联合调查员)和Demichelis博士(联合调查员)。全 CBBC调查人员是经验丰富的科学家，拥有广泛的出版物和赠款记录 在他们的领域中，并撰写了前列腺癌的第一本、最后一本或合著的出版物。CBBC调查人员已经 开发了关键的计算生物学方法，从途径和基序分析(IPAGE和FIRE)到 融合检测(FusionSeq)和肿瘤与突变克隆分析(CLONET)。除了分析之外 服务，计算生物学和生物统计核心将提供对一些 核心调查人员开发的计算工具以及直接获取设计专业知识 以及基因组和表观基因组实验的分析。计算生物学和生物统计学的核心将 利用计算生物医学研究所(ICB)的共享计算基础设施 在威尔·康奈尔医学(WCM)和已经在此背景下开发的临床级计算管道 在WCM/纽约长老会医院(NYPH)英格兰精密医学研究所(IPM)。 具体地说，CBBC将提供基因组、表观基因组和转录图谱的计算分析 属于该孢子的所有项目和核心(目标1)。CBBC还将提供全方位的 为属于孢子的所有项目和核心提供统计服务(目标2)。项目1(由Dr Beltran和Demichelis)、项目2(由Rickman和Beltran博士共同领导)、项目3(由Rubin博士、 汤姆林斯和沈从文)和项目4(由巴比耶里博士和沈从文共同领导)都将使用CBBC。此外，CBBC 将在DRP和CEP项目发展过程中提供支持。

COMPUTATIONAL BIOLOGY AND BIOSTATISTICS CORE SUMMARY The Computational Biology and Biostatistics Core (CBBC) will provide essential computational and biostatistical services and resources for all projects of the WCM SPORE in Prostate Cancer (PCa). Analytic services include statistical design and analysis, extensive quality control, integrative analysis and interpretation of genomic (DNA-seq, RNA-seq) epigenomic (ChIP-seq, bisulfite sequencing) datasets and implementation and development of custom computational pipelines needed by the projects. Core investigators include Drs Elemento and Ballman (Co-Directors), Dr Sboner (Co-investigator) and Dr Demichelis (Co-investigator). All CBBC investigators are highly experienced scientists with an extensive track record of publications and grants in their field and have authored first, last or co-author publications in prostate cancer. CBBC investigators have developed key computational biology methods ranging from pathway and motif analysis (iPAGE and FIRE) to fusion detection (FusionSeq) and tumor and mutational clonality analysis (CLONET). In addition to analytic services, the Computational Biology and Biostatistics Core will provide centralized access to a number of computational tools developed by the core investigators as well as direct access to expertise for the design and analysis of genomic and epigenomic experiments. The Computational Biology and Biostatistics Core will take advantage of the shared computational infrastructure of the Institute for Computational Biomedicine (ICB) at Weill Cornell Medicine (WCM) and of clinical-grade computational pipelines already developed in the context of the WCM/NewYork-Presbyterian Hospital (NYPH) Englander Institute for Precision Medicine (IPM). Specifically, CBBC will provide computational analysis of genomic, epigenomic, and transcriptional profiling for all Projects and Cores that are part of this SPORE (Aim 1). CBBC will also provide the full spectrum of statistical services for all Projects and Cores that are part of the SPORE (Aim 2). Project 1 (co-led by Dr Beltran and Demichelis), Project 2 (co-led by Drs Rickman and Beltran), Project 3 (co-led by Drs. Rubin, Tomlins, and Shen) and Project 4 (co-led by Dr. Barbieri and Shen) will all use the CBBC. In addition, CBBC will support DRP and CEP projects as they develop.