Morris K. Udall Centers of Excellence for Parkinson's Disease Research at Emory University

埃默里大学莫里斯·尤德尔帕金森病研究卓越中心

• 批准号: 10284843
• 负责人: Thomas N Wichmann
• 金额: $ 239.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-29 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10284843
• 关键词: Address; Administrator; Affect; Algorithmic Analysis; American; Anatomy; Animals; Antiparkinson Agents; Area; Basal Ganglia; Basic Science; Behavior Control; Behavior assessment; Brain; Caregivers; Cell Nucleus; Cells; Cerebral cortex; Clinic; Clinical; Clinical Sciences; Collaborations; Communities; Community Outreach; Complement; Data Analyses; Deep Brain Stimulation; Development; Disease; Dopaminergic Agents; Education; Education and Outreach; Educational Activities; Electrocorticogram; Electroencephalography; Event; Fostering; Foundations; Functional disorder; Funding; General Population; Goals; Grant; Human; Human Resources; Image; Information Centers; Institution; Journals; K-12 student; Knowledge; Levodopa; Light; Logistics; Mission; Modeling; Monkeys; Morphology; Motor; Motor Cortex; Movement Disorders; Neurons; Neurosciences; Parkinson Disease; Parkinsonian Disorders; Patients; Pattern; Physiology; Population; Primates; Recommendation; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Rodent; Role; Scientist; Series; Services; Signal Transduction; Slice; Social Workers; Societies; Structure; Students; Synapses; Therapeutic; Therapeutic Intervention; Tissue Sample; Training; Translational Research; Universities; Work; age group; biomedical referral center; career; catalyst; clinical care; clinical translation; collaborative environment; connectome; data sharing; design; experience; experimental study; in vivo; innovation; insight; interest; intervention effect; laboratory experience; motor control; nonhuman primate; outreach; parkinsonian non-human primate; programs; recruit; relating to nervous system; response; science education; side effect; statistical service; symptom treatment; treatment optimization; virtual; voltage; web site

Project Summary – Overall Center The Morris K. Udall Parkinson's Disease Center of Excellence for Parkinson’s Disease Research at Emory University is a collaborative research program that studies the pathophysiology of parkinsonism with the goal of optimizing the treatment for Parkinson’s disease (PD). The Center draws upon the proven ability of the basal ganglia research community at Emory to conduct collaborative translational research. Other Udall Center assets are the availability of primates for research at the Yerkes National Primate Research Center at Emory, and the presence of one of the largest movement disorders clinic in the US. The Center consists of four projects and three cores. The planned research will shed light on the poorly understood parkinsonism-related activity changes of specifically identified groups of projection neurons in the cerebral cortex which, in turn, will help us to better understand the pathophysiology of parkinsonism, and to optimize therapeutic strategies. Project 1 (led by Dr. Jaeger) will utilize rodent experiments for large-scale voltage imaging and brain slice recordings and use neural computational approaches to develop mechanistic models of cortical dysfunction in parkinsonism. Project 2 (Dr. Galvan), will explore the spontaneous and task-related activity of corticostriatal and corticospinal neurons in the primary motor cortex (M1) and the supplementary motor area (SMA) in normal and parkinsonian monkeys, using an opto-tagging approach to identify the projection targets of the recorded neurons. Project 3 (Dr. Smith) will examine morphological changes in the M1 and SMA microcircuitry and parkinsonism-associated changes in the connectome of cortical projection neurons in primates, a topic that is virtually unexplored and of high relevance to the interpretation of data in projects 1 and 2. The clinical ‘Catalyst’ project 4 is an examination of parkinsonism-related changes in cortical activity in response inhibition tasks, studied in electrocorticography and electroencephalography signals in patients with PD. The functional experiments will also study the effects of levodopa and deep brain stimulation treatments in these paradigms. All projects will be supported by an administrative core (Core A, Dr. Wichmann, PI; Dr. Smith, Associate Director, Ms Holbrook, administrator), and by a service core that provides anatomical services to projects 1 and 2, behavioral assessments to projects 2 and 3, and statistical services to all projects (Core B, Dr. Galvan). A clinical core (Core C) will support project 4 with recruitment and logistic services for the human studies. In addition to pursuing its research mission (aim 1), the Center will help young scientists to develop their career in PD research (aim 2), and will engage in extensive outreach efforts, aimed at communicating the Center’s (and Udall Center network) research findings to the public (aim 3), reaching all age groups and background levels. As part of the outreach agenda, the center plans to organize annual outreach events for patients and their caregivers. Generous internal support funds will help the Center to fund some of its education and outreach missions, as well as its pilot grant program, designed to expand PD research at Emory.

项目摘要 - 整体中心 莫里斯·帕金森氏病帕金森氏病帕金森氏病研究中心 大学是一项合作研究计划，研究了帕金森氏症的病理生理学 优化帕金森氏病（PD）的治疗方法。该中心借鉴了基本的可靠能力 Emory的神经节研究社区进行合作转化研究。其他UDALL中心资产是在埃默里（Emory）的Yerkes国家灵长类动物研究中心的主要研究 以及美国最大的运动障碍诊所之一的存在。该中心由四个项目和三个核心组成。计划的研究将阐明知识较低的帕金森氏症与活动的活动变化，在大脑皮层中特定鉴定的投射神经元组的变化反过来又将 帮助我们更好地了解帕金森氏症的病理生理学，并优化治疗策略。项目1（由Jaeger博士领导）将利用啮齿动物实验进行大规模的电压成像和脑切片记录，并使用神经计算方法来开发帕金森主义中皮质功能障碍的机械模型。项目2（Galvan博士）将探讨皮质纹状体的赞助和任务相关的活动 一级运动皮质（M1）中的皮质脊髓神经元和正常的补充运动区域（SMA） 帕金森尼猴子使用选择方法来识别记录的神经元的项目目标。项目3（史密斯博士）将检查M1和SMA微电路和帕金森氏症与私人皮质投影神经元连接组的变化的形态变化，这个主题几乎是意想不到的，并且与项目1和2中的数据解释相关，并且与临床“催化剂”项目4的解释相关。 PD患者的皮质学和脑电图信号。功能实验 还将研究这些范式中左旋多巴和深脑刺激治疗的影响。所有项目 将由行政核心（Core A，Wichmann博士，PI； Smith博士，MS）的支持 霍尔布鲁克（Holbrook），管理员），以及通过为项目1和项目提供解剖学服务的服务核心，对项目2和3的行为评估以及所有项目的统计服务（Core B，Galvan博士）。临床 Core（Core C）将支持项目4的招聘和物流服务。此外 该中心追求其研究任务（AIM 1），将帮助年轻科学家在PD研究中发展职业（AIM 2），并将从事广泛的外展工作，旨在传达该中心（和Udall） 中心网络）向公众进行研究结果（AIM 3），达到所有年龄段和背景水平。作为一部分 在外展议程中，该中心计划为患者及其护理人员组织年度外展活动。 一般内部支持资金将帮助该中心资助其一些教育和外展任务，因为 以及其试点赠款计划，旨在扩大Emory的PD研究。