Morris K. Udall Centers of Excellence for Parkinson's Disease Research at Emory University

埃默里大学莫里斯·尤德尔帕金森病研究卓越中心

• 批准号: 10495205
• 负责人: Thomas N Wichmann
• 金额: $ 235.93万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-29 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10495205
• 关键词: Address; Administrator; Affect; Algorithmic Analysis; American; Anatomy; Animals; Antiparkinson Agents; Area; Basal Ganglia; Basic Science; Behavior Control; Behavior assessment; Brain; Caregivers; Cell Nucleus; Cells; Cerebral cortex; Clinic; Clinical; Clinical Sciences; Collaborations; Communities; Community Outreach; Complement; Data Analyses; Deep Brain Stimulation; Development; Disease; Dopaminergic Agents; Education; Education and Outreach; Educational Activities; Electrocorticogram; Electroencephalography; Event; Fostering; Foundations; Functional disorder; Funding; General Population; Goals; Grant; Human; Human Resources; Image; Information Centers; Institution; Journals; K-12 student; Knowledge; Levodopa; Light; Logistics; Mission; Modeling; Monkeys; Morphology; Motor; Motor Cortex; Movement Disorders; Neurons; Neurosciences; Parkinson Disease; Parkinsonian Disorders; Patients; Pattern; Persons; Physiology; Population; Primates; Recommendation; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Rodent; Role; Scientist; Series; Services; Signal Transduction; Slice; Social Workers; Societies; Structure; Students; Synapses; Therapeutic; Therapeutic Intervention; Tissue Sample; Training; Translational Research; Universities; Work; age group; biomedical referral center; career; catalyst; clinical care; clinical translation; collaborative environment; connectome; data sharing; design; experience; experimental study; in vivo; innovation; insight; interest; intervention effect; laboratory experience; motor control; nonhuman primate; outreach; parkinsonian non-human primate; programs; recruit; relating to nervous system; response; science education; side effect; statistical service; symptom treatment; treatment optimization; virtual; voltage; web site

Project Summary – Overall Center The Morris K. Udall Parkinson's Disease Center of Excellence for Parkinson’s Disease Research at Emory University is a collaborative research program that studies the pathophysiology of parkinsonism with the goal of optimizing the treatment for Parkinson’s disease (PD). The Center draws upon the proven ability of the basal ganglia research community at Emory to conduct collaborative translational research. Other Udall Center assets are the availability of primates for research at the Yerkes National Primate Research Center at Emory, and the presence of one of the largest movement disorders clinic in the US. The Center consists of four projects and three cores. The planned research will shed light on the poorly understood parkinsonism-related activity changes of specifically identified groups of projection neurons in the cerebral cortex which, in turn, will help us to better understand the pathophysiology of parkinsonism, and to optimize therapeutic strategies. Project 1 (led by Dr. Jaeger) will utilize rodent experiments for large-scale voltage imaging and brain slice recordings and use neural computational approaches to develop mechanistic models of cortical dysfunction in parkinsonism. Project 2 (Dr. Galvan), will explore the spontaneous and task-related activity of corticostriatal and corticospinal neurons in the primary motor cortex (M1) and the supplementary motor area (SMA) in normal and parkinsonian monkeys, using an opto-tagging approach to identify the projection targets of the recorded neurons. Project 3 (Dr. Smith) will examine morphological changes in the M1 and SMA microcircuitry and parkinsonism-associated changes in the connectome of cortical projection neurons in primates, a topic that is virtually unexplored and of high relevance to the interpretation of data in projects 1 and 2. The clinical ‘Catalyst’ project 4 is an examination of parkinsonism-related changes in cortical activity in response inhibition tasks, studied in electrocorticography and electroencephalography signals in patients with PD. The functional experiments will also study the effects of levodopa and deep brain stimulation treatments in these paradigms. All projects will be supported by an administrative core (Core A, Dr. Wichmann, PI; Dr. Smith, Associate Director, Ms Holbrook, administrator), and by a service core that provides anatomical services to projects 1 and 2, behavioral assessments to projects 2 and 3, and statistical services to all projects (Core B, Dr. Galvan). A clinical core (Core C) will support project 4 with recruitment and logistic services for the human studies. In addition to pursuing its research mission (aim 1), the Center will help young scientists to develop their career in PD research (aim 2), and will engage in extensive outreach efforts, aimed at communicating the Center’s (and Udall Center network) research findings to the public (aim 3), reaching all age groups and background levels. As part of the outreach agenda, the center plans to organize annual outreach events for patients and their caregivers. Generous internal support funds will help the Center to fund some of its education and outreach missions, as well as its pilot grant program, designed to expand PD research at Emory.

项目概要——整体中心 埃默里大学莫里斯·尤德尔帕金森病研究卓越中心 大学是一个合作研究项目，研究帕金森病的病理生理学，其目标是 优化帕金森病（PD）的治疗。该中心利用了基础设施已被证实的能力 埃默里大学的神经节研究社区进行合作转化研究。尤德尔中心的其他资产包括埃默里耶基斯国家灵长类动物研究中心提供的灵长类动物用于研究， 以及美国最大的运动障碍诊所之一的存在。该中心由四个项目和三个核心组成。计划中的研究将揭示人们对大脑皮层中专门识别的投射神经元组的帕金森病相关活动变化知之甚少的情况，而这些变化反过来将 帮助我们更好地了解帕金森病的病理生理学，并优化治疗策略。项目 1（由 Jaeger 博士领导）将利用啮齿动物实验进行大规模电压成像和脑切片记录，并使用神经计算方法开发帕金森症皮质功能障碍的机制模型。项目 2（Galvan 博士）将探索皮质纹状体和任务相关的自发活动和 正常和正常情况下初级运动皮层 (M1) 和辅助运动区 (SMA) 中的皮质脊髓神经元 帕金森猴，使用光标记方法来识别记录的神经元的投射目标。项目 3（Smith 博士）将检查 M1 和 SMA 微电路的形态变化以及灵长类动物皮层投射神经元连接组中与帕金森病相关的变化，这个主题实际上尚未探索，并且与项目 1 和 2 中数据的解释高度相关。临床“催化剂”项目 4 是检查反应抑制任务中与帕金森病相关的皮层活动变化，研究 PD 患者的皮质电图和脑电图信号。功能实验 还将研究左旋多巴和深部脑刺激治疗在这些范例中的效果。所有项目 将得到行政核心的支持（核心 A，Wichmann 博士，PI；Smith 博士，副主任，Ms Holbrook，管理员），以及为项目 1 和 2 提供解剖服务、为项目 2 和 3 提供行为评估以及为所有项目提供统计服务的服务核心（核心 B，Galvan 博士）。临床一 核心（核心 C）将支持项目 4，为人类研究提供招募和后勤服务。此外 在履行其研究使命（目标 1）的同时，该中心将帮助年轻科学家在 PD 研究领域发展职业生涯（目标 2），并将开展广泛的外展工作，旨在传达该中心（和 Udall）的研究成果。 中心网络）向公众公布研究成果（目标3），覆盖所有年龄段和背景水平。作为一部分 在外展议程中，该中心计划为患者及其护理人员组织年度外展活动。 慷慨的内部支持资金将帮助该中心为其一些教育和外展任务提供资金，因为 及其试点资助计划，旨在扩大埃默里大学的PD研究。