Udall Parkinson's Disease Research Center at Emory University

埃默里大学尤德尔帕金森病研究中心

• 批准号: 9356330
• 负责人: Thomas N Wichmann
• 金额: $ 137.03万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9356330
• 关键词: Address; Administrator; Adverse effects; Affect; Algorithmic Analysis; American; Anatomy; Animals; Antiparkinson Agents; Area; Assisted Living Facilities; Basal Ganglia; Basic Science; Behavior; Behavior Control; Brain; Caregivers; Cell Nucleus; Cells; Cerebral cortex; Child; Clinic; Clinical; Clinical Sciences; Collaborations; Communities; Community Outreach; Complement; Data Analyses; Deep Brain Stimulation; Development; Disease; Education; Education and Outreach; Educational Activities; Electron Microscopy; Fostering; Foundations; Functional disorder; Funding; Future Teacher; General Population; Goals; Grant; High School Student; Human Resources; Immunohistochemistry; Information Centers; Institutes; Institution; Journals; K-12 student; Knowledge; Light; Link; Mission; Modeling; Monkeys; Morphology; Motivation; Movement Disorders; Neurosciences; Parkinson Disease; Parkinsonian Disorders; Patients; Pattern; Physiology; Population; Primates; Recommendation; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Role; Scientist; Series; Services; Slice; Social Workers; Societies; Standardization; Structure; Students; Synapses; Thalamic structure; Therapeutic Intervention; Time; Tissue Sample; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Work; age group; biomedical referral center; career; career development; clinical care; clinical movement disorder; clinical translation; collaborative environment; data sharing; design; experience; experimental study; in vivo; innovation; insight; interest; intervention effect; laboratory experience; motor control; neuroregulation; outreach; outreach program; programs; relating to nervous system; retiree; science education; symposium; virtual; web site

The Morris K. Udall Parkinson's Disease Center of Excellence for Parkinson's Disease Research at Emory University is a collaborative research program in which electrophysiologists and anatomists study the pathophysiology of parkinsonism, and examine and optimize the effects of existing treatments for Parkinson's disease. The Center draws upon the proven ability of the basal ganglia research community at Emory to conduct translational research. Other Udall Center assets are its close ties to the clinical movement disorders group at Emory, and the availability of primates for research at the Yerkes National Primate Research Center at Emory University. Emory is strongly committed to the Udall Center's research, and supports the Center by funding pilot grants, invited speakers, and portions of its education and outreach programs. The Center consists of three tightly linked projects and two cores. The planned research will shed light on the poorly understood parkinsonism-related activity changes in thalamus and cortex which, in turn, will help us to better understand the pathophysiology of parkinsonism, and to optimize existing neuromodulation strategies and to develop new ones. Project 1 (led by Dr. Jaeger) will utilize brain slice and in vivo recordings in rodents, as well as a neural computational approach to develop mechanistic models of thalamocortical dysfunction in parkinsonism. Project 2 (Dr. Wichmann), will continue the exploration of thalamic and cortical abnormalities in parkinsonian monkeys, using selective activation and inactivation approaches which are designed to study corticothalamic, pallidothalamic and thalamocortical information transfer. Project 3 (Dr. Smith) will examine morphological changes in the thalamic and cortical microcircuitry in parkinsonian primates, a topic that is virtually unexplored at this time and of high relevance to the interpretation of data in the other projects. All projects will be supported by an Administrative Core (Dr. Wichmann, PI; Dr. DeLong, Co-I, Dr. Smith, Co-I, Ms Holbrook, administrator), and by an Anatomy and Behavior Core (Dr. Galvan) which will provide immunohistochemistry and electron microscopy services to all of the center projects, and standardized MPTP treatment and quantification of parkinsonism to the primate experiments in Projects 2 and 3. In addition to pursuing its research mission (Aim 1), the Center will help junior scientists to develop their career in Parkinson's disease research (Aim 2), and will engage in extensive outreach efforts, aimed at communicating the Center's (and Udall Center network) research findings to the public (Aim 3), reaching all age groups and background levels, ranging from K-12 children to retirees in assisted living facilities. As part of the outreach agenda, the center plans to organize annual symposia for patients and their caregivers. The center will be generously supported by the University. These internal support funds will help the Center to fund some of its education and outreach missions, as well as its pilot grant program, designed to expand Parkinson's disease research at Emory University.

埃默里大学莫里斯·尤德尔帕金森病研究卓越中心是一个合作研究项目，电生理学家和解剖学家研究帕金森病的病理生理学，并检查和优化现有帕金森病治疗方法的效果。该中心利用埃默里大学基底神经节研究界经过验证的能力进行转化研究。尤德尔中心的其他资产包括与埃默里大学临床运动障碍小组的密切联系，以及埃默里大学耶克斯国家灵长类动物研究中心可提供灵长类动物进行研究。埃默里大学坚定地致力于尤德尔中心的研究，并通过资助试点拨款、特邀演讲者以及部分教育和外展项目来支持该中心。 该中心由三个紧密相连的项目和两个核心组成。计划中的研究将揭示丘脑和皮质中与帕金森病相关的活动变化知之甚少，这反过来又将帮助我们更好地了解帕金森病的病理生理学，优化现有的神经调节策略并开发新的策略。项目 1（由 Jaeger 博士领导）将利用啮齿动物的脑切片和体内记录以及神经计算方法来开发帕金森病丘脑皮质功能障碍的机制模型。项目 2（Wichmann 博士）将继续探索帕金森猴的丘脑和皮质异常，采用选择性激活和失活方法，旨在研究皮质丘脑、苍白丘脑和丘脑皮质信息传递。项目 3（史密斯博士）将检查帕金森灵长类动物的丘脑和皮质微电路的形态变化，这个主题目前实际上尚未被探索，并且与其他项目中数据的解释高度相关。所有项目都将得到行政核心（Wichmann 博士、PI；DeLong 博士、Co-I 博士、Smith 博士、Co-I、Holbrook 女士，管理员）和解剖学和行为核心（Galvan 博士）的支持，该核心将为所有中心项目提供免疫组织化学和电子显微镜服务，并对项目 2 和 3 中的灵长类动物实验提供标准化 MPTP 治疗和帕金森病定量。 除了其研究使命（目标 1）之外，该中心将帮助初级科学家发展帕金森病研究的职业生涯（目标 2），并将开展广泛的外展工作，旨在向公众传播该中心（和尤德尔中心网络）的研究成果（目标 3），覆盖所有年龄组和背景水平，从 K-12 儿童到辅助生活设施中的退休人员。作为外展议程的一部分，该中心计划为患者及其护理人员组织年度研讨会。该中心将得到大学的慷慨支持。这些内部支持资金将帮助该中心资助其一些教育和外展任务，以及旨在扩大埃默里大学帕金森病研究的试点拨款计划。