The 'Career MODE' Program: Careers through Mentoring and training in Omics and Data for Early-stage investigators

项目摘要/摘要 美国国家科学院描述了科学家在从 将独立研究作为对美国生物医学科学未来的最关键威胁 州(美国)。妇女和边缘化群体的个人面临着更大的障碍，特别是在 经济科学等技术密集型领域。尽管NIH单独进行了拨款审查和支付热线，但 调查人员首次领取R01的平均年龄继续攀升至46岁，创历史新高。 延续了35年的负面趋势。与此同时，博士毕业生成为教授的可能性 在过去的几十年里显著下降，将美国生物医学研究的未来置于危险之中。 为了应对这些挑战，我们提出了“职业模式”计划：通过指导和 为早期研究人员提供OMICS和数据方面的培训，以增强不同的年轻研究人员队伍的能力 在全美--即，指导培训最后几年的博士后和两年内的教职员工 他们的第一个任命--在组学和数据科学领域建立独立、成功的职业生涯。组学- 从基因组学到微生物组，都给生物医学科学带来了革命性的变化。因为他们已经变成了 作为任何生物医学领域的一部分，每个学科中缺乏接受过适当的经济学培训的劳动力 这是一项关键的挑战。我们寻求制定一个为期11个月的计划，在以下方面提供强化培训 由70名导师组成的全国范围内的多样化网络提供组学和数据科学以及专业指导。职业生涯 MODE还将以专业技能培训为特色，包括领导力和团队管理， 写作，指导，目标设定和战略制定，沟通和教学，科学严谨， 透明度、可再现性、负责任的研究行为和健康公平。通过在全国范围内利用其 职业模式还将提供一种结构化的方法来加强协作 和网络，帮助创建突破性研究项目团队以及K99/R00和R01类型的拨款 建议，进一步的职业发展，并帮助确保终身教职的职位和教师晋升。 职业模式将以混合(虚拟和面对面)课程和学习活动(新兵训练营、 圆桌会议、小组讨论、专题讨论会、观察者)，对每个目标进行强有力的评价，并将产生和 广泛传播有关组学和数据科学的教育材料。该计划将向 最有前途、最有动力、最多样化的初级调查人员--这是一个传统上资源有限的群体-- 创建授权的科学家队伍，通过先进的知识和工具追求独立性 组学和数据科学适用于所有生物医学研究领域。因此，我们的计划与NIGMS保持一致 目标和提供高回报的投资。我们还将制定促进公平和准入的战略。 在组学研究和推广职业模式方面，以学术机构、赞助商和利益相关者的方式达成 超过五年R25资金的财务可持续性和自给自足。

PROJECT SUMMARY/ABSTRACT The National Academy of Sciences describes the barriers that scientists experience on the path from mentored to independent research as the single most critical threat to the future of biomedical sciences in the United States (US). Women and individuals from marginalized groups face steeper obstacles, particularly in technology-intensive fields such as omic sciences. Despite NIH’s separate grant reviews and paylines, the mean age at which investigators receive their first R01 has continued to climb to an all-time high of 46 years, extending a 35-year negative trend. In parallel, the likelihood of PhD graduates becoming professors has dropped significantly in the last decades, putting the future of biomedical research in the US at risk. To address these challenges, we propose the 'Career MODE' program: Careers through Mentoring and training in Omics and Data for Early-stage investigators to empower diverse cohorts of young researchers across the US—i.e., postdocs in the final years of mentored training and faculty members within two years of their first appointment—to establish independent, successful careers in omics and data sciences. Omics— ranging from genomics to the microbiome—have revolutionized biomedical sciences. As they have become part of any biomedical field, the scarcity of a workforce within each discipline with appropriate omic training has emerged as a critical challenge. We seek to develop an 11-month program to provide intensive training in omics and data science and specialized mentoring from a nationwide, diverse network of 70+ mentors. Career MODE will also feature training in professional skills, including leadership and team management, grant writing, mentoring, goal setting and strategy development, communication and teaching, scientific rigor, transparency, reproducibility, responsible conduct of research, and health equity. By leveraging its nationwide group of mentors and trainees, Career MODE will also offer a structured approach to enhance collaborations and networking, help create teams for breakthrough research projects and K99/R00 and R01-type grant proposals, further career development, and help secure tenure-track positions and faculty promotions. Career MODE will feature hybrid (virtual and in-person) coursework and learning activities (boot camps, roundtables, panels, symposia, observerships), a robust evaluation of each objective, and will generate and disseminate extensive educational material on omics and data science. The program will do outreach to the most promising, motivated, and diverse junior investigators—a group traditionally with limited resources— to create empowered cohorts of scientists to pursue independence through advanced knowledge and tools in omics and data sciences applicable to all biomedical research fields. Thus, our program aligns with NIGMS goals and provides a high return for investment. We will also develop strategies to advance equity and access in omics research and promote Career MODE to academic institutions, sponsors, and stakeholders to reach financial sustainability and self-support beyond the five years of R25 funding.