The 'Career MODE' Program: Careers through Mentoring and training in Omics and Data for Early-stage investigators

项目概要/摘要 美国国家科学院描述了科学家从接受指导的道路上遇到的障碍。 独立研究是对美国生物医学科学未来的最严重威胁。 美国。妇女和边缘化群体的个人面临更大的障碍，特别是在 技术密集型领域，如经济科学。尽管NIH有单独的拨款审查和支付线， 研究人员获得第一个R 01的平均年龄继续攀升至46岁的历史最高水平， 延续了35年的负增长趋势。与此同时，博士毕业生成为教授的可能性 在过去的几十年里，这一数字大幅下降，使美国生物医学研究的未来处于危险之中。 为了应对这些挑战，我们提出了“职业模式”计划：通过指导和 为早期研究人员提供组学和数据培训，以增强不同年龄组的年轻研究人员的能力 在美国各地-即，博士后在最后几年的指导培训和教员在两年内 他们的第一个目标是在组学和数据科学领域建立独立、成功的职业生涯。组学- 从基因组学到微生物组学，已经彻底改变了生物医学科学。因为他们已经成为 作为任何生物医学领域的一部分，每个学科都缺乏受过适当组学培训的劳动力， 成为一个严峻的挑战。我们寻求制定一个为期11个月的计划，提供强化培训， 经济学和数据科学以及来自全国范围内的70多位导师的专业指导。职业生涯 MODE还将提供专业技能培训，包括领导力和团队管理， 写作，指导，目标设定和战略制定，沟通和教学，科学严谨， 透明度、可重复性、负责任的研究行为和健康公平。通过利用其全国范围内的 由导师和学员组成的职业模式还将提供一个有条理的方法来加强合作 和网络，帮助创建突破性研究项目团队以及K99/R 00和R 01类型的资助 建议，进一步的职业发展，并帮助确保终身职位和教师晋升。 职业模式将以混合（虚拟和面对面）课程和学习活动（靴子训练营， 圆桌会议、小组讨论会、专题讨论会、研讨会），对每个目标进行有力的评估，并将产生和 广泛传播关于组学和数据科学的教育材料。该计划将做外展到 最有前途的，积极的，和多样化的初级教师-一组传统上资源有限- 建立有能力的科学家队伍，通过先进的知识和工具追求独立， 适用于所有生物医学研究领域的组学和数据科学。因此，我们的计划与NIGMS保持一致 目标，并为投资提供高回报。我们还将制定战略，促进公平和机会 在组学研究和促进职业模式，以学术机构，赞助商和利益相关者达到 在R25供资的五年之后，财政可持续性和自我支持。

PROJECT SUMMARY/ABSTRACT The National Academy of Sciences describes the barriers that scientists experience on the path from mentored to independent research as the single most critical threat to the future of biomedical sciences in the United States (US). Women and individuals from marginalized groups face steeper obstacles, particularly in technology-intensive fields such as omic sciences. Despite NIH’s separate grant reviews and paylines, the mean age at which investigators receive their first R01 has continued to climb to an all-time high of 46 years, extending a 35-year negative trend. In parallel, the likelihood of PhD graduates becoming professors has dropped significantly in the last decades, putting the future of biomedical research in the US at risk. To address these challenges, we propose the 'Career MODE' program: Careers through Mentoring and training in Omics and Data for Early-stage investigators to empower diverse cohorts of young researchers across the US—i.e., postdocs in the final years of mentored training and faculty members within two years of their first appointment—to establish independent, successful careers in omics and data sciences. Omics— ranging from genomics to the microbiome—have revolutionized biomedical sciences. As they have become part of any biomedical field, the scarcity of a workforce within each discipline with appropriate omic training has emerged as a critical challenge. We seek to develop an 11-month program to provide intensive training in omics and data science and specialized mentoring from a nationwide, diverse network of 70+ mentors. Career MODE will also feature training in professional skills, including leadership and team management, grant writing, mentoring, goal setting and strategy development, communication and teaching, scientific rigor, transparency, reproducibility, responsible conduct of research, and health equity. By leveraging its nationwide group of mentors and trainees, Career MODE will also offer a structured approach to enhance collaborations and networking, help create teams for breakthrough research projects and K99/R00 and R01-type grant proposals, further career development, and help secure tenure-track positions and faculty promotions. Career MODE will feature hybrid (virtual and in-person) coursework and learning activities (boot camps, roundtables, panels, symposia, observerships), a robust evaluation of each objective, and will generate and disseminate extensive educational material on omics and data science. The program will do outreach to the most promising, motivated, and diverse junior investigators—a group traditionally with limited resources— to create empowered cohorts of scientists to pursue independence through advanced knowledge and tools in omics and data sciences applicable to all biomedical research fields. Thus, our program aligns with NIGMS goals and provides a high return for investment. We will also develop strategies to advance equity and access in omics research and promote Career MODE to academic institutions, sponsors, and stakeholders to reach financial sustainability and self-support beyond the five years of R25 funding.