Evaluating the effect of water fluoridation on adverse birth outcomes

评估水氟化对不良分娩结局的影响

基本信息

批准号：
10284698
负责人：
Dana E Goin
金额：
$ 9.96万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10284698
关键词：
Affect Area Arsenic Award Biological Process Birth Birth Records Birth Weight California Cardiovascular system Characteristics Child Child Health Communities Community of Practice Consumption Country Data Data Science Development Education Endocrine Disruptors Endocrine system Environmental Exposure Environmental Hazards Environmental Risk Factor Epidemiologist Exposure to Fetal Growth Fetus Fluorides Funding Future Gestational Age Goals Grant Health High Risk Woman Hormones Illinois Individual Infant Infant Health Knowledge Lead Life Link Low Birth Weight Infant Machine Learning Maternal Exposure Maternal Health Measures Mentorship Metal exposure Mothers National Institute of Environmental Health Sciences Oral health Outcome Perinatal Epidemiology Play Policies Population Population Heterogeneity Predisposition Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Process Public Health Public Health Practice Research Research Personnel Research Training Risk Role San Francisco Second Pregnancy Trimester Services Shapes Small for Gestational Age Infant Socioeconomic Status Statistical Methods Subgroup System Techniques Temperature Thyroid Function Tests Thyroid Hormones Time Toxic effect Training Translating United States United States National Institutes of Health Universities Urine Variant Vulnerable Populations Water Water Supply Water fluoridation Whole Blood Woman Women Status adverse birth outcomes adverse pregnancy outcome clinical decision-making cohort drinking water environmental chemical fetal health disparity health of the mother healthy pregnancy improved in utero lead exposure low socioeconomic status male neurodevelopment novel perinatal health population health prenatal exposure pressure programs sex social social factors systemic inflammatory response urinary

项目摘要

Project Summary/Abstract The objective of this K99/R00 proposal is to estimate the effect of community water fluoridation on adverse birth outcomes in California and identify whether there are subpopulations who are especially vulnerable to fluoride exposure during pregnancy. Fluoride has been added to water supplies to promote dental health in the United States since 1945, but the impacts on pregnancy outcomes have never been assessed. It is possible that maternal and in-utero fetal exposure to fluoride increases risk of preterm birth and small-for- gestational age. A small number of studies in other countries suggest there is an increased risk of adverse birth outcomes associated with drinking water with naturally high levels of fluoride, and evidence suggests fluoride consumption can affect thyroid function and cardiovascular systems, both of which play important roles in regulating and maintaining a healthy pregnancy. Since 1995, California has required water systems with at least 10,000 service connections to fluoridate their water, but systems were only required to implement a fluoridation program once the funds were allocated. Therefore, there is a substantial amount of variability in which water systems have added fluoride over the last 25 years, and when they did so. We will leverage this variation in water fluoridation practices in California to (1) identify the effects of changes in water fluoridation on adverse birth outcomes during 2006-2017 and (2) evaluate whether there are heterogeneous exposure effects by maternal/fetal characteristics and environmental co-exposures. Furthermore, we will use the ECHO.CA.IL pregnancy cohort, which is composed of pregnant women and their children in San Francisco and Illinois, to (3a) assess whether maternal urinary fluoride during the second trimester is associated with reduced gestational age or lower birthweight-for-gestational-age-z-scores at birth and (3b) evaluate whether there are heterogeneous effects of exposure by maternal/fetal characteristics and environmental co-exposures. The research plan is bolstered by an exceptional mentorship team and training plan at the University of San Francisco, California. The proposed project builds on the applicant’s background in perinatal epidemiology and provides training in new statistical methods to identify heterogeneous exposure effects and education in the biological processes of gestation and parturition, exposure assessment of environmental chemicals, and translating scientific findings to policymakers. The combined research and training plans will enable the candidate to transition into an independent researcher of policy-relevant social and environmental factors that shape perinatal health. This research aligns with NIEHS’s strategic goals to evaluate health effects of the exposome, identify individual susceptibilities to environmental hazards, utilize data science techniques, and generate evidence that can be utilized by policymakers to improve population health.

项目摘要/摘要该K99/R00建议的目的是估算社区水氟化对广告的影响加利福尼亚州的出生成果，并确定是否有特别容易受到的亚群怀孕期间的氟化物暴露。氟化物已被添加到水供应中，以促进牙齿健康自1945年以来，美国，但对怀孕结果的影响从未得到评估。含氟化物的母乳和尿液中的胎儿暴露可能会增加早产的风险胎龄。在其他国家的少数研究表明，逆境风险增加与饮用水相关的出生结果，氟化物自然很高，有证据表明氟化物的消耗会影响甲状腺功能和心血管系统，这两者都起着重要作用在确定和维持健康的怀孕时。自1995年以来，加利福尼亚需要AT的水系统至少有10,000个服务连接以氟化水，但是只需要系统才能实施氟化计划一旦分配了资金。因此，有很大的可变性在过去的25年中，哪些供水系统增加了氟化物。我们将利用加利福尼亚水氟化实践的这种变化来确定变化的影响在2006 - 2017年期间的不良出生结果中氟化中，（2）评估是否存在产妇/胎儿特征和环境共曝光的异质暴露影响。此外，我们将使用由孕妇及其组成的Echo.ca.il妊娠队列旧金山和伊利诺伊州的儿童（3A）评估是否在第二次尿中尿孕期与胎龄降低或出生时胎龄较低有关（3b）评估母亲/胎儿特征和环境共同曝光。该研究计划由SAN大学的杰出指导团队和培训计划增强加利福尼亚州弗朗西斯科。拟议的项目以围产期流行病学和申请人背景为基础提供新的统计方法的培训，以识别在妊娠和分娩的生物学过程，环境化学物质的暴露评估以及将科学发现转化为政策制定者。联合研究和培训计划将使候选人过渡到与政策相关的社会和环境因素的独立研究人员形状围产健康。这项研究与NIEHS的战略目标一致，以评估展览会的健康影响，确定个人对环境危害，利用数据科学技术的敏感性，并产生可以是由决策者利用来改善人口健康。