Evaluating the effect of water fluoridation on adverse birth outcomes
评估水氟化对不良分娩结局的影响
基本信息
- 批准号:10284698
- 负责人:
- 金额:$ 9.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAreaArsenicAwardBiological ProcessBirthBirth RecordsBirth WeightCaliforniaCardiovascular systemCharacteristicsChildChild HealthCommunitiesCommunity of PracticeConsumptionCountryDataData ScienceDevelopmentEducationEndocrine DisruptorsEndocrine systemEnvironmental ExposureEnvironmental HazardsEnvironmental Risk FactorEpidemiologistExposure toFetal GrowthFetusFluoridesFundingFutureGestational AgeGoalsGrantHealthHigh Risk WomanHormonesIllinoisIndividualInfantInfant HealthKnowledgeLeadLifeLinkLow Birth Weight InfantMachine LearningMaternal ExposureMaternal HealthMeasuresMentorshipMetal exposureMothersNational Institute of Environmental Health SciencesOral healthOutcomePerinatal EpidemiologyPlayPoliciesPopulationPopulation HeterogeneityPredispositionPregnancyPregnancy OutcomePregnant WomenPremature BirthProcessPublic HealthPublic Health PracticeResearchResearch PersonnelResearch TrainingRiskRoleSan FranciscoSecond Pregnancy TrimesterServicesShapesSmall for Gestational Age InfantSocioeconomic StatusStatistical MethodsSubgroupSystemTechniquesTemperatureThyroid Function TestsThyroid HormonesTimeToxic effectTrainingTranslatingUnited StatesUnited States National Institutes of HealthUniversitiesUrineVariantVulnerable PopulationsWaterWater SupplyWater fluoridationWhole BloodWomanWomen Statusadverse birth outcomesadverse pregnancy outcomeclinical decision-makingcohortdrinking waterenvironmental chemicalfetalhealth disparityhealth of the motherhealthy pregnancyimprovedin uterolead exposurelow socioeconomic statusmaleneurodevelopmentnovelperinatal healthpopulation healthprenatal exposurepressureprogramssexsocialsocial factorssystemic inflammatory responseurinary
项目摘要
Project Summary/Abstract
The objective of this K99/R00 proposal is to estimate the effect of community water fluoridation on adverse
birth outcomes in California and identify whether there are subpopulations who are especially vulnerable to
fluoride exposure during pregnancy. Fluoride has been added to water supplies to promote dental health in the
United States since 1945, but the impacts on pregnancy outcomes have never been assessed.
It is possible that maternal and in-utero fetal exposure to fluoride increases risk of preterm birth and small-for-
gestational age. A small number of studies in other countries suggest there is an increased risk of adverse
birth outcomes associated with drinking water with naturally high levels of fluoride, and evidence suggests
fluoride consumption can affect thyroid function and cardiovascular systems, both of which play important roles
in regulating and maintaining a healthy pregnancy. Since 1995, California has required water systems with at
least 10,000 service connections to fluoridate their water, but systems were only required to implement a
fluoridation program once the funds were allocated. Therefore, there is a substantial amount of variability in
which water systems have added fluoride over the last 25 years, and when they did so.
We will leverage this variation in water fluoridation practices in California to (1) identify the effects of changes
in water fluoridation on adverse birth outcomes during 2006-2017 and (2) evaluate whether there are
heterogeneous exposure effects by maternal/fetal characteristics and environmental co-exposures.
Furthermore, we will use the ECHO.CA.IL pregnancy cohort, which is composed of pregnant women and their
children in San Francisco and Illinois, to (3a) assess whether maternal urinary fluoride during the second
trimester is associated with reduced gestational age or lower birthweight-for-gestational-age-z-scores at birth
and (3b) evaluate whether there are heterogeneous effects of exposure by maternal/fetal characteristics and
environmental co-exposures.
The research plan is bolstered by an exceptional mentorship team and training plan at the University of San
Francisco, California. The proposed project builds on the applicant’s background in perinatal epidemiology and
provides training in new statistical methods to identify heterogeneous exposure effects and education in the
biological processes of gestation and parturition, exposure assessment of environmental chemicals, and
translating scientific findings to policymakers. The combined research and training plans will enable the
candidate to transition into an independent researcher of policy-relevant social and environmental factors that
shape perinatal health.
This research aligns with NIEHS’s strategic goals to evaluate health effects of the exposome, identify individual
susceptibilities to environmental hazards, utilize data science techniques, and generate evidence that can be
utilized by policymakers to improve population health.
项目摘要/摘要
这项K99/R00提案的目的是评估社区水氟化对有害物质的影响
加州的出生结局并确定是否有特别容易患上这种疾病的亚群
孕期接触氟化物。已经在供水中添加了氟化物,以促进
自1945年以来一直在美国,但对妊娠结局的影响从未被评估过。
孕妇和宫内胎儿暴露在氟化物中可能会增加早产和小儿麻痹的风险。
胎龄。其他国家的少量研究表明,患癌症的风险增加
出生结局与饮用天然高氟化物的水有关,有证据表明
摄入氟化物会影响甲状腺功能和心血管系统,这两个方面都发挥着重要作用
在调节和维持健康怀孕方面的作用。自1995年以来,加利福尼亚州一直要求供水系统与AT
至少10,000个服务连接来为他们的水加氟,但系统只需要实施
一旦资金分配到位,就会实施氟化计划。因此,存在着大量的可变性
在过去的25年里,哪些供水系统添加了氟化物,以及它们何时添加了氟化物。
我们将利用加州水加氟实践中的这种变化来(1)确定变化的影响
2006-2017年间在水中加氟对不良生育结局的影响和(2)评估是否有
母亲/胎儿特征和环境共同暴露的异质性暴露效应。
此外,我们将使用ECHO.CA.IL妊娠队列,该队列由孕妇和他们的
旧金山和伊利诺伊州的儿童,以(3a)评估母亲第二次尿氟是否
妊娠三个月与胎龄减少或出生时出生体重与胎龄z分数降低有关
以及(3b)根据母亲/胎儿的特征评估暴露是否存在异质性影响,以及
环境共同暴露。
这项研究计划得到了旧金山大学杰出的指导团队和培训计划的支持
加利福尼亚州,弗朗西斯科。拟议的项目以申请者在围产期流行病学和
提供新的统计方法方面的培训,以确定不同的暴露影响和教育
妊娠和分娩的生物过程,环境化学品的暴露评估,以及
向政策制定者转化科学发现。综合研究和培训计划将使
转变为独立研究与政策相关的社会和环境因素的候选人
塑造围产期健康。
这项研究与NIEHS的战略目标一致,即评估暴露组对健康的影响,确定个人
易受环境危害的影响,利用数据科学技术,并生成可以
被政策制定者用来改善人口健康。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Dana E Goin', 18)}}的其他基金
Evaluating the effect of water fluoridation on adverse birth outcomes
评估水氟化对不良分娩结局的影响
- 批准号:
10889310 - 财政年份:2023
- 资助金额:
$ 9.96万 - 项目类别:
Drinking water contaminants and fetal loss in Northern California
北加州的饮用水污染物和胎儿丢失
- 批准号:
10727706 - 财政年份:2023
- 资助金额:
$ 9.96万 - 项目类别:
Evaluating the effect of water fluoridation on adverse birth outcomes
评估水氟化对不良分娩结局的影响
- 批准号:
10456197 - 财政年份:2021
- 资助金额:
$ 9.96万 - 项目类别:
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