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Evaluating the effect of water fluoridation on adverse birth outcomes

评估水氟化对不良分娩结局的影响

基本信息

批准号：
10456197
负责人：
Dana E Goin
金额：
$ 9.96万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10456197
关键词：
Affect Area Arsenic Award Biological Process Birth Birth Records Birth Weight California Cardiovascular system Characteristics Child Child Health Communities Community of Practice Consumption Country Data Data Science Development Education Endocrine Disruptors Endocrine system Environmental Exposure Environmental Hazards Environmental Risk Factor Epidemiologist Exposure to Fetal Growth Fetus Fluorides Funding Future Gestational Age Goals Grant Health High Risk Woman Hormones Illinois Individual Infant Infant Health Knowledge Lead Life Link Low Birth Weight Infant Machine Learning Maternal Exposure Maternal Health Measures Mentorship Metal exposure Mothers National Institute of Environmental Health Sciences Oral health Outcome Perinatal Epidemiology Play Policies Population Population Heterogeneity Predisposition Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Process Public Health Public Health Practice Research Research Personnel Research Training Risk Role San Francisco Second Pregnancy Trimester Services Shapes Small for Gestational Age Infant Socioeconomic Status Statistical Methods Subgroup System Techniques Temperature Thyroid Function Tests Thyroid Hormones Time Toxic effect Training Translating United States United States National Institutes of Health Universities Urine Variant Vulnerable Populations Water Water Supply Water fluoridation Whole Blood Woman Women Status adverse birth outcomes adverse pregnancy outcome clinical decision-making cohort drinking water environmental chemical fetal health disparity health of the mother healthy pregnancy improved in utero lead exposure low socioeconomic status male neurodevelopment novel perinatal health population health prenatal exposure pressure programs sex social social factors systemic inflammatory response urinary

项目摘要

Project Summary/Abstract The objective of this K99/R00 proposal is to estimate the effect of community water fluoridation on adverse birth outcomes in California and identify whether there are subpopulations who are especially vulnerable to fluoride exposure during pregnancy. Fluoride has been added to water supplies to promote dental health in the United States since 1945, but the impacts on pregnancy outcomes have never been assessed. It is possible that maternal and in-utero fetal exposure to fluoride increases risk of preterm birth and small-for- gestational age. A small number of studies in other countries suggest there is an increased risk of adverse birth outcomes associated with drinking water with naturally high levels of fluoride, and evidence suggests fluoride consumption can affect thyroid function and cardiovascular systems, both of which play important roles in regulating and maintaining a healthy pregnancy. Since 1995, California has required water systems with at least 10,000 service connections to fluoridate their water, but systems were only required to implement a fluoridation program once the funds were allocated. Therefore, there is a substantial amount of variability in which water systems have added fluoride over the last 25 years, and when they did so. We will leverage this variation in water fluoridation practices in California to (1) identify the effects of changes in water fluoridation on adverse birth outcomes during 2006-2017 and (2) evaluate whether there are heterogeneous exposure effects by maternal/fetal characteristics and environmental co-exposures. Furthermore, we will use the ECHO.CA.IL pregnancy cohort, which is composed of pregnant women and their children in San Francisco and Illinois, to (3a) assess whether maternal urinary fluoride during the second trimester is associated with reduced gestational age or lower birthweight-for-gestational-age-z-scores at birth and (3b) evaluate whether there are heterogeneous effects of exposure by maternal/fetal characteristics and environmental co-exposures. The research plan is bolstered by an exceptional mentorship team and training plan at the University of San Francisco, California. The proposed project builds on the applicant’s background in perinatal epidemiology and provides training in new statistical methods to identify heterogeneous exposure effects and education in the biological processes of gestation and parturition, exposure assessment of environmental chemicals, and translating scientific findings to policymakers. The combined research and training plans will enable the candidate to transition into an independent researcher of policy-relevant social and environmental factors that shape perinatal health. This research aligns with NIEHS’s strategic goals to evaluate health effects of the exposome, identify individual susceptibilities to environmental hazards, utilize data science techniques, and generate evidence that can be utilized by policymakers to improve population health.

项目总结/摘要本K99/R 00提案的目的是评估社区水氟化对不利环境的影响。出生结果在加州，并确定是否有亚群谁是特别容易受到怀孕期间接触氟化物。氟化物已被添加到供水，以促进牙齿健康，美国自1945年以来，但对妊娠结局的影响从未被评估过。母亲和胎儿在子宫内接触氟化物可能会增加早产和小胎儿的风险。胎龄其他国家的少数研究表明，出生结果与饮用天然高水平氟化物的水有关，有证据表明，氟的消耗会影响甲状腺功能和心血管系统，这两个系统都起着重要的作用在调节和维持一个健康的怀孕。自1995年以来，加州要求供水系统至少有10，000个服务连接来氟化他们的水，但系统只需要实施一个一旦资金到位，就开始实施氟化项目。因此，存在大量的可变性，在过去的25年里，哪些水系统添加了氟化物，以及他们何时这样做。我们将利用加州水氟化实践的这种变化来（1）确定变化的影响在2006-2017年期间，水氟化对不良出生结果的影响;（2）评估是否存在母体/胎儿特征和环境共同暴露的异质暴露效应。此外，我们将使用ECHO.CA.IL妊娠队列，该队列由孕妇及其儿童在旧金山弗朗西斯科和伊利诺伊州，（3a）评估是否产妇尿氟在第二次孕三个月与出生时胎龄减少或出生体重-胎龄-Z评分降低相关和（3b）根据母体/胎儿特征评估是否存在暴露的异质效应，环境共暴露。该研究计划得到了旧金山大学卓越的导师团队和培训计划的支持加州的弗朗西斯科。拟议的项目建立在申请人在围产期流行病学的背景，提供新的统计方法的培训，以确定异质性暴露影响和教育，妊娠和分娩的生物过程，环境化学品的接触评估，以及将科学发现转化为政策制定者。合并的研究和培训计划将使候选人过渡到政策相关的社会和环境因素，塑造围产期健康。这项研究符合NIEHS的战略目标，以评估健康影响的麻烦，确定个人对环境危害的敏感性，利用数据科学技术，并生成可以政策制定者用来改善人口健康。