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Drinking water contaminants and fetal loss in Northern California

北加州的饮用水污染物和胎儿丢失

基本信息

批准号：
10727706
负责人：
Dana E Goin
金额：
$ 18.6万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-10 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10727706
关键词：
Address Affect Arsenic Benchmarking Benzene Birth Birth Records Blood California Characteristics Chemicals Climate Clinic Visits Cohort Studies Collaborations Communities Computerized Medical Record Data Data Sources Droughts Education Electronic Health Record Ensure Environmental Hazards Ethnic Origin Exclusion Exposure to Fetal health Fetus General Population Gestational Age Goals Health Health Status Heavy Metals Hormonal Household Human Rights Immunologics Incidence Individual Intervention Knowledge Lead Link Literature Live Birth Manganese Maternal Health Metals Monitor National Institute of Child Health and Human Development National Institute of Environmental Health Sciences Nitrates Occupational Exposure Outcome Overlapping Genes Participant Persons Policy Maker Population Population Heterogeneity Pregnancy Pregnancy Complications Pregnancy loss Prenatal care Prevalence Prevention Public Health Race Recording of previous events Records Regulation Reproductive Health Research Research Personnel Risk Risk Reduction Socioeconomic Status Spontaneous abortion System Time Toxicogenomics United States Universities Uranium Vanadium Visit Water Water Pollutants Water Supply Wildfire Work adverse birth outcomes chromium hexavalent ion climate change cohort contaminated water density drinking water environmental justice experience fetal loss health disparity health goals improved marginalized population novel population health pregnant racial disparity socioeconomics stillbirth water quality water testing

项目摘要

PROJECT SUMMARY/ABSTRACT The objective of this R03 proposal is to characterize the rates of miscarriage and stillbirth by gestational week in a Northern California population, and to evaluate whether climate change-sensitive drinking water contaminants increase rates of miscarriage and stillbirth. We also aim to estimate the effects of a hypothetical intervention of reducing water contaminant levels on risk of fetal loss. The relationships between drinking water contaminants and risks of miscarriage and stillbirth have not been investigated in California since the early 1980s. As climate change threatens the quality of drinking water in the state, it is important to better understand how climate-sensitive drinking water contaminants affect reproductive health. There is a significant gap in research on environmental determinants of fetal loss at a population level. This is likely due to the challenges in studying early fetal loss, as existing data sources have difficulty capturing miscarriage. However, electronic health record data can help us improve our knowledge of fetal loss between 10 and 20 weeks of gestation, when many pregnant people have received a prenatal care visit but whose pregnancies would not be captured in birth records. We propose to use Sutter Health’s electronic medical records to identify pregnancies, and link participants to community water system boundaries using residential address at each clinic visit. We will then assign water contaminant levels based on the annual average contaminant levels collected from public water monitoring information at the water system level in California. The goals of this project are to 1) characterize the rate of fetal loss in a diverse California cohort, 2) evaluate the individual and mixture effects of climate-sensitive water contaminants on rates of fetal loss, and 3) assess whether reducing all water contaminants to their 50th percentiles observed in the study cohort reduces the risk of fetal loss. The research plan is supported by a strong team of investigators from UCSF, Sutter Health, UC Berkeley, and Columbia University. The investigators have a strong history of collaboration and experience working with electronic health records. They bring significant expertise in reproductive health, drinking water contaminants, climate change, and environmental justice. This research addresses a significant gap in the literature and aligns with both NIEHS’s goal to generate evidence that can be used by policymakers to improve population health, and NICHD’s goals to understand contributors to pregnancy loss and to help identify targets for effective prevention of health disparities.

项目总结/文摘