T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis

人复发性扁桃体炎中滤泡辅助性 T (Tfh) CD4 T 细胞、生发中心和抗体反应功能障碍

• 批准号: 10304742
• 负责人: Shane P Crotty
• 金额: $ 126.39万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-17 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10304742
• 关键词: 2019-nCoV; Address; Antibody Response; B-Lymphocytes; Bacteria; CD4 Positive T Lymphocytes; COVID-19; COVID-19 pandemic; COVID-19 severity; Clinical; Common Cold; Contracts; Coronavirus Infections; Functional disorder; Human; Immune; Individual; Infection; Longitudinal Studies; Measurement; Politics; Recurrence; Reporting; Risk; Role; SARS-CoV-2 infection; Structure of germinal center of lymph node; T cell response; T memory cell; Tonsillitis; Viral Load result; Virus; cohort; experimental study; memory CD4 T lymphocyte; response

PROJECT SUMMARY Pre-existing T cell memory to SARS-CoV-2 is detectable in ~50% of people. We first reported this, and we have since shown that this may largely be due to crossreactive memory CD4+ T cells from common cold coronavirus (CCC) infections. While this observation has been reproduced on three continents, the big unanswered question is whether these crossreactive memory T cells (i) confer some form of protection against COVID-19 disease severity, (ii) have no impact on COVID-19 severity, or (iii) increase COVID-19 disease severity. This issue has been widely discussed in scientific, public, and political spheres, and it potentially has major ramifications for understanding the COVID-19 pandemic. The direct experiment to address this topic is a longitudinal study of uninfected individuals at risk for acquisition of SARS-CoV-2, then assessing COVID-19 disease severity in individuals who contract SARS-CoV-2 infection, stratified between individuals who did or did not have pre- existing T cell memory to SARS-CoV-2.

项目摘要 在约50％的人中，可以检测到SARS-COV-2的T细胞存储器预先存在的T细胞记忆。我们首先报告了这一点，我们有 由于表明这可能主要是由于共同冷冠状病毒的交叉反应记忆CD4+ T细胞 （CCC）感染。虽然该观察结果已经在三大洲进行了复制，但一个很大的未解决问题 这些交叉反应性记忆T细胞（i）是否提供了针对Covid-19疾病的某种形式的保护 严重程度，（ii）对COVID-19的严重程度没有影响，或者（iii）增加了COVID-199疾病的严重程度。这个问题有 在科学，公众和政治领域中广泛讨论，它可能对 了解19009年大流行。解决此主题的直接实验是对 未感染的个体有可能获得SARS-COV-2的风险，然后评估Covid-19中的疾病严重程度 感染SARS-COV-2感染的个人，在没有或没有的个人之间分层 现有的T细胞内存到SARS-COV-2。