课题基金 / 基金详情

T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis

T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis
人复发性扁桃体炎中滤泡辅助性 T (Tfh) CD4 T 细胞、生发中心和抗体反应功能障碍
批准号：
10169568
负责人：
Shane P Crotty
金额：
$38.62万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-05-26 至 2021-02-28
来源：
https://reporter.nih.gov/project-details/10169568
关键词：
2019-nCoVAntibody ResponseAntigensB-LymphocytesBacteriaBiologyBronchoalveolar LavageCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCOVID-19COVID-19 vaccineCellsDevelopmentDiseaseEpitopesFunctional disorderHelper-Inducer T-LymphocyteHumanImmune responseImmunologicsImpairmentInfectionInterventionKnowledgeLungMeasuresMedicalPatientsPeptidesPeripheral Blood Mononuclear CellPhenotypeRecurrenceResolutionSeverity of illnessStructure of germinal center of lymph nodeT cell responseT-LymphocyteT-Lymphocyte EpitopesTechniquesTherapeuticTonsillitisVaccinesViruscost effectivecytokinein vivoinnovationpandemic diseasepathogenresponsetherapy development

项目摘要

项目成果

Shane P Crotty的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Overall Component COVID19 is a severe ongoing pandemic. Our understanding of the immune response to this disease is lacking, which impairs both the development of proper therapeutics and a vaccine. Vaccines are one of the most cost effective and extraordinarily successful medical interventions. Most of those vaccines depend on CD4 T+ cells and their help to B cells. We have developed multiple new techniques to study human CD4+ T cells over the past several years, which have have been implementing in our LJI CCHI. The supplement proposed here will facilitate rapid and vigorous pursuit of an understanding of the T cell responses to SARS-CoV2 in humans, which may help in the development of treatments and vaccines for COVID19.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Immune engineering of optimized sequential immunization strategies for HIV vaccines
Immune engineering of optimized sequential immunization strategies for HIV vaccines
T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis
  • 批准号：
    10304742
  • 项目类别：
  • 资助金额：
    $126.39万
  • 财政年份：
    2020
  • 负责人：
    Shane P Crotty
  • 依托单位：
    LA JOLLA INSTITUTE FOR IMMUNOLOGY
Administrative Core
  • 批准号：
    10591866
  • 项目类别：
  • 资助金额：
    $6.88万
  • 财政年份：
    2020
  • 负责人：
    Shane P Crotty
  • 依托单位：
    UNIVERSITY OF FLORIDA
海外基金