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T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis

T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis
人复发性扁桃体炎中滤泡辅助性 T (Tfh) CD4 T 细胞、生发中心和抗体反应功能障碍
批准号：
10169568
负责人：
Shane P Crotty
金额：
$38.62万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-05-26 至 2021-02-28
来源：
https://reporter.nih.gov/project-details/10169568
关键词：
2019-nCoVAntibody ResponseAntigensB-LymphocytesBacteriaBiologyBronchoalveolar LavageCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCOVID-19COVID-19 vaccineCellsDevelopmentDiseaseEpitopesFunctional disorderHelper-Inducer T-LymphocyteHumanImmune responseImmunologicsImpairmentInfectionInterventionKnowledgeLungMeasuresMedicalPatientsPeptidesPeripheral Blood Mononuclear CellPhenotypeRecurrenceResolutionSeverity of illnessStructure of germinal center of lymph nodeT cell responseT-LymphocyteT-Lymphocyte EpitopesTechniquesTherapeuticTonsillitisVaccinesViruscost effectivecytokinein vivoinnovationpandemic diseasepathogenresponsetherapy development

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中文摘要
翻译
总体组件 COVID 19是一种严重的持续流行病。我们对这种疾病的免疫反应缺乏了解， 这损害了适当疗法和疫苗的开发。疫苗是成本最高的 有效和非常成功的医疗干预。大多数疫苗依赖于CD4 T+细胞 以及它们对B细胞的帮助。过去，我们开发了多种新技术来研究人类CD 4 + T细胞 几年来，这已经在我们的LJI CCHI实施。此处建议的补充将有助于 快速而有力地追求对人类T细胞对SARS-CoV2反应的理解，这可能 帮助开发COVID 19的治疗方法和疫苗。
英文摘要
Overall Component COVID19 is a severe ongoing pandemic. Our understanding of the immune response to this disease is lacking, which impairs both the development of proper therapeutics and a vaccine. Vaccines are one of the most cost effective and extraordinarily successful medical interventions. Most of those vaccines depend on CD4 T+ cells and their help to B cells. We have developed multiple new techniques to study human CD4+ T cells over the past several years, which have have been implementing in our LJI CCHI. The supplement proposed here will facilitate rapid and vigorous pursuit of an understanding of the T cell responses to SARS-CoV2 in humans, which may help in the development of treatments and vaccines for COVID19.
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Immune engineering of optimized sequential immunization strategies for HIV vaccines
Immune engineering of optimized sequential immunization strategies for HIV vaccines
T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis
  • 批准号：
    10304742
  • 项目类别：
  • 资助金额：
    $126.39万
  • 财政年份：
    2020
  • 负责人：
    Shane P Crotty
  • 依托单位：
    LA JOLLA INSTITUTE FOR IMMUNOLOGY
Administrative Core
  • 批准号：
    10591866
  • 项目类别：
  • 资助金额：
    $6.88万
  • 财政年份：
    2020
  • 负责人：
    Shane P Crotty
  • 依托单位：
    UNIVERSITY OF FLORIDA
海外基金