Center for Aging and Policy Studies - Alzheimer's Disease Research Supplement

老龄化与政策研究中心 - 阿尔茨海默病研究增刊

• 批准号: 10286938
• 负责人: Jennifer Karas Montez
• 金额: $ 22.17万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10286938
• 关键词: Address; Administrative Supplement; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Behavioral; Biological Markers; Buffers; Cause of Death; Child; Cognitive aging; Consumption; Dementia; Demography; Development; Diagnosis; Down Syndrome; Economics; Elderly; Family; Family member; Fostering; Funding; Grant; Health; Impaired cognition; Incidence; Income; Individual; Interdisciplinary Study; London; Measures; Parents; Pathway interactions; Personal Satisfaction; Pilot Projects; Policies; Population; Prevalence; Program Development; Reporting; Request for Applications; Research; Research Support; Research Training; Resources; Risk; Risk Factors; Role; Rural; Scientist; Shock; Social Sciences; Surveys; Testing; Universities; Yang; arterial stiffness; base; burden of illness; cognitive change; data resource; disability; human capital; innovation; intergenerational; knowledge base; middle age; modifiable risk; mortality; novel; population based; programs; social; urban area

The proposed research consists of five distinct Pilot Projects, each of which will be carried out as part of the Center for Aging and Policy Studies (CAPS)’s Program Development (Pilot) Core (Core B). All five are population-based social science studies that address one or more of NIA’s announced priorities in the area of Alzheimer’s disease and related dementias (ADRD) research. Two of the proposed tasks represent a broadening of the analyses conducted in existing Pilot Projects. (1) Consequences of Disabilities in Late Middle Age for Consumption Well- Being, will examine the consequences of disability in late middle age for economic well-being using consumption-based measures instead of the usual income-based measures. (2) Health Shocks and Changes in Spatial Proximity between Parents and Children will study how changes in spatial proximity of family members evolves relative to changes in health, such as an AD diagnosis. The remaining three projects represent new, ADRD-focused studies that contribute to CAPS’s Specific Aims. (3) Estimated Arterial Stiffness as a Predictor of Cognitive Decline and Dementia in Middle-Aged and Older Adults will use a novel survey-based measure of arterial stiffness to predict cognitive decline and the transition to a dementia diagnosis. (4) Comparing Alzheimer’s Related Mortality Among People with and without Down Syndrome examines differences between those with and without Down syndrome with respect to ADRD prevalence and in reported cause of death. (5) Living alone and risk for the development of Alzheimer’s Disease and related dementias: When does solitary living matter and why will investigate the role of living alone as a risk factor for ADRD onset, as well as the presence of factors that buffer this risk. Together, these projects will produce important new findings in a number of priority areas, including the proposed research will address both the prevalence and the incidence of cognitive decline and dementia; will inform the knowledge base with respect to trajectories of cognitive decline and aging; and will provide new findings on the consequences for individuals and their families of prevalent ADRD, adding to our knowledge about the population-level burden of illness. Additionally, one of the proposed projects will develop and apply an innovative approach to using biomarkers as an early sign of dementia, which promises to add to our knowledge regarding causal pathways to cognitive decline and ADRD, and to suggest possible malleable mechanistic targets on behavioral and social pathways to ADRD.

拟议的研究包括五个不同的试点项目，每个试点项目都将作为 老龄化与政策研究中心S项目开发(试点)核心(核心)的一部分 b)。这五项研究都是以人口为基础的社会科学研究，涉及NIA的一个或多个 宣布阿尔茨海默病和相关痴呆领域的优先事项(ADRD) 研究。拟议的任务中有两项是扩大现有的 试点。(1)中年后期残疾对良好消费的后果- 将研究中年后期残疾对经济福祉的影响 使用以消费为基础的衡量标准，而不是通常以收入为基础的衡量标准。(2)健康 父母和孩子之间的空间接近程度的冲击和变化将如何研究 家庭成员的空间邻近性的变化相对于健康的变化而演变，例如 AD诊断。剩下的三个项目是新的、以ADRD为重点的研究，它们有助于 卡普斯的具体目标。(3)动脉僵硬对认知功能衰退的预测作用 中老年人的痴呆症将使用一种新的基于调查的测量方法 动脉僵硬可以预测认知功能下降和向痴呆诊断的过渡。(4) 唐氏综合征患者与非唐氏综合征患者阿尔茨海默病相关死亡率的比较 研究唐氏综合症患者与非唐氏综合征患者在ADRD方面的差异 流行率和报告的死因中。(5)独居和发展的风险 阿尔茨海默病和相关痴呆：独居生活什么时候重要？为什么重要？ 调查独居作为ADRD发病危险因素的作用，以及 缓冲这种风险的因素。这些项目加在一起，将在一个 若干优先领域，包括拟议的研究，将处理流行率和 认知功能减退和痴呆症的发生率；将向知识库提供关于 认知衰退和衰老的轨迹；并将就其后果提供新的发现 对于流行的ADRD的个人及其家人，增加了我们对 人口层面的疾病负担。此外，其中一个拟议的项目将开发和 应用一种创新的方法使用生物标记物作为痴呆症的早期迹象，这有望 为了增加我们关于认知衰退和ADRD的因果路径的知识，并 在ADRD的行为和社会途径上建议可能的可塑性机械性目标。