Center for Aging and Policy Studies - Alzheimer's Disease Research Supplement

拟议的研究包括五个不同的试点项目，每个项目将作为 老龄化和政策研究中心（CAPS）的计划发展（试点）核心（核心）的一部分 B）。所有五个都是基于人口的社会科学研究，解决一个或多个NIA的 宣布阿尔茨海默病和相关痴呆症（ADRD）领域的优先事项 research.其中两项拟议任务是扩大现有的 试点项目。(1)中年晚期残疾对消费的影响 存在，将研究中年后期残疾对经济福祉的影响 使用基于消费的衡量标准，而不是通常的基于收入的衡量标准。(2)健康 父母和孩子之间空间接近的冲击和变化将研究如何 家庭成员空间接近度的变化与健康状况的变化有关，例如 AD诊断其余三个项目代表了新的、以ADRD为重点的研究， CAPS的具体目标。(3)动脉僵硬度估计值作为认知功能下降的预测指标 和老年痴呆症将使用一种新的基于调查的措施， 动脉硬度来预测认知能力下降和向痴呆诊断的转变。（四） 唐氏综合征患者与非唐氏综合征患者阿尔茨海默病相关死亡率的比较 检查有和没有唐氏综合征的人在ADRD方面的差异 患病率和报告的死亡原因。(5)独居和发展风险 阿尔茨海默病和相关痴呆症：何时独居重要，为什么会 研究独居作为ADRD发作的风险因素的作用，以及 缓冲这种风险的因素。总之，这些项目将产生重要的新发现， 一些优先领域，包括拟议的研究将解决流行和 认知能力下降和痴呆症的发病率;将告知知识库， 认知能力下降和衰老的轨迹;并将提供有关后果的新发现 为个人和他们的家庭流行的ADRD，增加了我们的知识， 人口一级的疾病负担。此外，其中一个拟议项目将开发和 应用创新的方法，使用生物标志物作为痴呆症的早期迹象， 增加我们对认知能力下降和ADRD因果途径的了解， 提示ADRD的行为和社会途径可能具有可塑性的机制靶点。

The proposed research consists of five distinct Pilot Projects, each of which will be carried out as part of the Center for Aging and Policy Studies (CAPS)’s Program Development (Pilot) Core (Core B). All five are population-based social science studies that address one or more of NIA’s announced priorities in the area of Alzheimer’s disease and related dementias (ADRD) research. Two of the proposed tasks represent a broadening of the analyses conducted in existing Pilot Projects. (1) Consequences of Disabilities in Late Middle Age for Consumption Well- Being, will examine the consequences of disability in late middle age for economic well-being using consumption-based measures instead of the usual income-based measures. (2) Health Shocks and Changes in Spatial Proximity between Parents and Children will study how changes in spatial proximity of family members evolves relative to changes in health, such as an AD diagnosis. The remaining three projects represent new, ADRD-focused studies that contribute to CAPS’s Specific Aims. (3) Estimated Arterial Stiffness as a Predictor of Cognitive Decline and Dementia in Middle-Aged and Older Adults will use a novel survey-based measure of arterial stiffness to predict cognitive decline and the transition to a dementia diagnosis. (4) Comparing Alzheimer’s Related Mortality Among People with and without Down Syndrome examines differences between those with and without Down syndrome with respect to ADRD prevalence and in reported cause of death. (5) Living alone and risk for the development of Alzheimer’s Disease and related dementias: When does solitary living matter and why will investigate the role of living alone as a risk factor for ADRD onset, as well as the presence of factors that buffer this risk. Together, these projects will produce important new findings in a number of priority areas, including the proposed research will address both the prevalence and the incidence of cognitive decline and dementia; will inform the knowledge base with respect to trajectories of cognitive decline and aging; and will provide new findings on the consequences for individuals and their families of prevalent ADRD, adding to our knowledge about the population-level burden of illness. Additionally, one of the proposed projects will develop and apply an innovative approach to using biomarkers as an early sign of dementia, which promises to add to our knowledge regarding causal pathways to cognitive decline and ADRD, and to suggest possible malleable mechanistic targets on behavioral and social pathways to ADRD.