Biomarkers Project for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的生物标志物项目
基本信息
- 批准号:10289798
- 负责人:
- 金额:$ 16.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-16 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAfrican AmericanAssessment toolAvena sativaBetaineBioinformaticsBiological MarkersBlood PressureBreadCalibrationCarbohydratesCarotenoidsChickensChronic DiseaseCitrusClinicalComplexConsumptionCoupledDataData AnalysesDevelopmentDietDiet MonitoringDiet RecordsDietary AssessmentDietary ComponentDietary InterventionDietary PracticesDiseaseDisease ManagementDrug KineticsEatingEnergy IntakeEquationEvaluationFatty AcidsFolic AcidFollow-Up StudiesFoodFoundationsFrequenciesFutureGoldHealthHealth ProfessionalHispanicsHourHumanIndividualIntakeInterventionIsoflavonesKnowledgeLife StyleLightMeasurementMeasuresMetabolismMethodologyMethodsNitrogenNurses&apos Health StudyNutrientNutritionalNutritional StudyObservational StudyParticipantPatient Self-ReportPatternPerformancePhasePhysical activityPlant ProteinsPlasmaPopulationPotassiumPotatoPreventionProlinePropertyProteinsQuestionnairesRandomizedRecoveryReportingResearchResearch PersonnelResourcesRye cerealSamplingScientistSeriesSodiumStatistical Data InterpretationStrategic PlanningStudy of LatinosTechniquesTestingTimeUnited States National Institutes of HealthUniversitiesUnsaturated FatsUrineVascular PlantWheatWomanWorkbasebeefbiomarker developmentbiomarker discoverybiomarker validationblood lipidcohortcost effectivedata resourcedietarydisorder preventiondoubly-labeled waterexperiencefeedingimprovedindexinginnovationintervention effectmenmetabolomicsmicrobialmicrobiomemicrobiome compositionmulti-ethnicmultidisciplinarynovelnovel markernutritionnutritional epidemiologyprecision nutritionresponsesoyspecific biomarkerstoolurinaryvalidation studies
项目摘要
PROJECT SUMMARY/ABSTRACT – BIOMARKERS PROJECT
Accurate dietary assessments are a major challenge in nutritional research, especially among free-living
individuals. In contrast to self-reported dietary assessments, dietary biomarkers are more objective and less
prone to reporting errors. However, traditional dietary biomarker discovery methods are rate-limiting and rely
on prior knowledge of food composition. Advances in metabolomic profiling techniques, coupled with feeding
trials, now pave the road for discovering novel food biomarkers more efficiently, although the list of sensitive
and specific food biomarkers is still short. In response to the RFA-DK-20-005, this proposal, which is specific
for the Biomarkers Project (BP) Core, will focus on the characterization of pharmacokinetics of novel food
biomarkers and validation of food biomarkers in both clinical feeding trial and observational study settings in
multiple independent populations. Specifically, at Phase 1, based on data and resources to be generated at the
Intervention Core, we will calculate half-lives of novel food biomarkers, estimate other pharmacokinetics
features of the markers, and establish calibration curves and functions for computing food intake. At Phase 2,
we will evaluate changes of food biomarkers following 6-week dietary interventions (DASH-style high-
carbohydrate diet, high plant protein diet, and high unsaturated fat diet) implemented in the OmniHeart feeding
trial. We will further use multiple markers to construct a diet quality score and examine the effects of the
interventions on the score. At Phase 3, we will validate the food biomarkers using dietary data assessed by the
gold-standard 7-day diet records and other validated tools in the Lifestyle Validation Study (LVS) and Study of
Latinos Nutrition & Physical Activity Assessment Study (SOLNAS). We will further build measurement error
correction equations based on the calibration curves and explore inter-relationships between diet, microbiome,
and food biomarkers. These proposed projects at the BP Core will significantly accelerate the advances in food
biomarker discovery and validation in U.S. populations. In addition, the overall complementary, inter-connected
projects proposed for the Harvard Dietary Biomarker Development Center will be led by a highly experienced
investigator team consisting of researchers with expertise in feeding trials, metabolomics, bioinformatics,
nutritional biomarker research, and nutritional epidemiology. The interdisciplinary expertise and rich, existing
resources of multi-ethnic cohorts in the U.S. will lead to significant scientific yields in a cost-effective manner.
Data to be generated from the BP Core will not only characterize and validate novel food markers but also
build the foundation for applying the food biomarkers in a broad range of research settings, such as evaluation
of diet-disease associations or monitoring of dietary compliance. As such, the proposed research has a great
potential to advance dietary assessment methodology and to aid in future research toward the development of
precision or individualized nutrition strategies for chronic disease prevention and management.
项目摘要/摘要-生物标志物项目
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Qi Sun', 18)}}的其他基金
Biomarkers Project for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的生物标志物项目
- 批准号:
10649596 - 财政年份:2021
- 资助金额:
$ 16.18万 - 项目类别:
Biomarkers Project for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的生物标志物项目
- 批准号:
10461136 - 财政年份:2021
- 资助金额:
$ 16.18万 - 项目类别:
FOOD-BASED BIOMARKERS, DIET QUALITY, AND CARDIOMETABOLIC HEALTH
基于食物的生物标志物、饮食质量和心脏代谢健康
- 批准号:
10598569 - 财政年份:2019
- 资助金额:
$ 16.18万 - 项目类别:
FOOD-BASED BIOMARKERS, DIET QUALITY, AND CARDIOMETABOLIC HEALTH
基于食物的生物标志物、饮食质量和心脏代谢健康
- 批准号:
10381662 - 财政年份:2019
- 资助金额:
$ 16.18万 - 项目类别:
FOOD-BASED BIOMARKERS, DIET QUALITY, AND CARDIOMETABOLIC HEALTH
基于食物的生物标志物、饮食质量和心脏代谢健康
- 批准号:
9913534 - 财政年份:2019
- 资助金额:
$ 16.18万 - 项目类别:
Environmental Obesogens and Weight Change in the POUNDS LOST Trial
POUNDS LOST 试验中的环境致肥胖因素和体重变化
- 批准号:
10376884 - 财政年份:2014
- 资助金额:
$ 16.18万 - 项目类别:
Environmental Obesogens and Weight Change in the POUNDS LOST Trial
POUNDS LOST 试验中的环境致肥胖因素和体重变化
- 批准号:
10596998 - 财政年份:2014
- 资助金额:
$ 16.18万 - 项目类别:
Environmental Obesogens and Weight Change in the POUNDS LOST Trial
POUNDS LOST 试验中的环境致肥胖因素和体重变化
- 批准号:
8761806 - 财政年份:2014
- 资助金额:
$ 16.18万 - 项目类别:
Environmental Obesogens and Weight Change in the POUNDS LOST Trial
POUNDS LOST 试验中的环境致肥胖因素和体重变化
- 批准号:
9060931 - 财政年份:2014
- 资助金额:
$ 16.18万 - 项目类别:
Environmental Obesogens and Weight Change in the POUNDS LOST Trial
POUNDS LOST 试验中的环境致肥胖因素和体重变化
- 批准号:
10160911 - 财政年份:2014
- 资助金额:
$ 16.18万 - 项目类别:
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