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Biomarkers Project for the Dietary Biomarkers Development Center at Harvard University

哈佛大学膳食生物标志物开发中心的生物标志物项目

基本信息

批准号：
10289798
负责人：
Qi Sun
金额：
$ 16.18万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-16 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10289798
关键词：
Address Adult African American Assessment tool Avena sativa Betaine Bioinformatics Biological Markers Blood Pressure Bread Calibration Carbohydrates Carotenoids Chickens Chronic Disease Citrus Clinical Complex Consumption Coupled Data Data Analyses Development Diet Diet Monitoring Diet Records Dietary Assessment Dietary Component Dietary Intervention Dietary Practices Disease Disease Management Drug Kinetics Eating Energy Intake Equation Evaluation Fatty Acids Folic Acid Follow-Up Studies Food Foundations Frequencies Future Gold Health Health Professional Hispanics Hour Human Individual Intake Intervention Isoflavones Knowledge Life Style Light Measurement Measures Metabolism Methodology Methods Nitrogen Nurses&apos Health Study Nutrient Nutritional Nutritional Study Observational Study Participant Patient Self-Report Pattern Performance Phase Physical activity Plant Proteins Plasma Population Potassium Potato Prevention Proline Property Proteins Questionnaires Randomized Recovery Reporting Research Research Personnel Resources Rye cereal Sampling Scientist Series Sodium Statistical Data Interpretation Strategic Planning Study of Latinos Techniques Testing Time United States National Institutes of Health Universities Unsaturated Fats Urine Vascular Plant Wheat Woman Work base beef biomarker development biomarker discovery biomarker validation blood lipid cohort cost effective data resource dietary disorder prevention doubly-labeled water experience feeding improved indexing innovation intervention effect men metabolomics microbial microbiome microbiome composition multi-ethnic multidisciplinary novel novel marker nutrition nutritional epidemiology precision nutrition response soy specific biomarkers tool urinary validation studies

项目摘要

PROJECT SUMMARY/ABSTRACT – BIOMARKERS PROJECT Accurate dietary assessments are a major challenge in nutritional research, especially among free-living individuals. In contrast to self-reported dietary assessments, dietary biomarkers are more objective and less prone to reporting errors. However, traditional dietary biomarker discovery methods are rate-limiting and rely on prior knowledge of food composition. Advances in metabolomic profiling techniques, coupled with feeding trials, now pave the road for discovering novel food biomarkers more efficiently, although the list of sensitive and specific food biomarkers is still short. In response to the RFA-DK-20-005, this proposal, which is specific for the Biomarkers Project (BP) Core, will focus on the characterization of pharmacokinetics of novel food biomarkers and validation of food biomarkers in both clinical feeding trial and observational study settings in multiple independent populations. Specifically, at Phase 1, based on data and resources to be generated at the Intervention Core, we will calculate half-lives of novel food biomarkers, estimate other pharmacokinetics features of the markers, and establish calibration curves and functions for computing food intake. At Phase 2, we will evaluate changes of food biomarkers following 6-week dietary interventions (DASH-style high- carbohydrate diet, high plant protein diet, and high unsaturated fat diet) implemented in the OmniHeart feeding trial. We will further use multiple markers to construct a diet quality score and examine the effects of the interventions on the score. At Phase 3, we will validate the food biomarkers using dietary data assessed by the gold-standard 7-day diet records and other validated tools in the Lifestyle Validation Study (LVS) and Study of Latinos Nutrition & Physical Activity Assessment Study (SOLNAS). We will further build measurement error correction equations based on the calibration curves and explore inter-relationships between diet, microbiome, and food biomarkers. These proposed projects at the BP Core will significantly accelerate the advances in food biomarker discovery and validation in U.S. populations. In addition, the overall complementary, inter-connected projects proposed for the Harvard Dietary Biomarker Development Center will be led by a highly experienced investigator team consisting of researchers with expertise in feeding trials, metabolomics, bioinformatics, nutritional biomarker research, and nutritional epidemiology. The interdisciplinary expertise and rich, existing resources of multi-ethnic cohorts in the U.S. will lead to significant scientific yields in a cost-effective manner. Data to be generated from the BP Core will not only characterize and validate novel food markers but also build the foundation for applying the food biomarkers in a broad range of research settings, such as evaluation of diet-disease associations or monitoring of dietary compliance. As such, the proposed research has a great potential to advance dietary assessment methodology and to aid in future research toward the development of precision or individualized nutrition strategies for chronic disease prevention and management.

项目摘要/摘要-生物标志物项目