Bicoastal Marmoset Breeding Center

双海岸狨猴繁育中心

• 批准号: 10289057
• 负责人: XIAOQIN WANG
• 金额: $ 29.82万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10289057
• 关键词: Administrative Supplement; Age; Age-Years; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer’s disease biomarker; Amyloidosis; Anatomy; Animal Model; Animals; Award; Biological Models; Biomedical Research; Brain; Breeding; Callithrix; Callithrix jacchus jacchus; Communities; Country; Dementia; Disease; Funding; Goals; Housing; Human; Longevity; Modeling; Parents; Physiological; Pilot Projects; Primates; Request for Applications; Research; Research Personnel; Resource Development; Resources; Source; United States National Institutes of Health; Work; age related; gene interaction; human old age (65+); nonhuman primate; offspring; programs; public health relevance; response

Nonhuman primates (NHP) are crucial animal models for research on Alzheimer’s disease and its related dementias because of their closest evolutionary relatives of humans, with whom they share anatomical, physiological, and gene interactions features. The common marmoset (Callithrix jacchus) is a NHP model of increasing importance for aging research. This new world primate provides some unique advantages for the study of aging and aging-related disorders, including its relatively short lifespan among all the NHP used in biomedical research. There has been an increasing number of investigators who are currently using or would like to use marmosets as a model system to study aging and age-related diseases including Alzheimer’s disease. However, there is a significant bottleneck for the research in this field. There are currently no reliable distributors of marmosets for biomedical research in the country. The situation is even direr for researchers who need access to aging marmosets. Recognizing such a bottleneck, NIH has recently funded two marmoset breeding programs including the parent award of this application (“Bicoastal Marmoset Breeding Center”, U24- MH123423). The goal of the proposed project is to fill the gap in the availability of aging marmosets for the study of Alzheimer’s disease and its related dementias. We could use this center to develop a resource of aging marmosets for Alzheimer's disease studies. This resource will be extremely valuable to the scientific community studying Alzheimer's disease and its related dementias.

非人灵长类动物是研究阿尔茨海默病及其相关疾病的重要动物模型 痴呆症，因为他们最接近人类的进化亲属，与他们分享解剖， 生理和基因相互作用特征。普通绒猴（Callithrix jacchus）是一种NHP模型， 对老龄化研究越来越重要。这种新的世界灵长类动物提供了一些独特的优势， 衰老和衰老相关疾病的研究，包括其在所有NHP中使用的相对较短的寿命， 生物医学研究越来越多的调查人员目前正在使用或将使用 我喜欢用绒猴作为模型系统来研究衰老和与年龄有关的疾病，包括阿尔茨海默氏症 疾病然而，在这一领域的研究存在一个重大的瓶颈。目前没有可靠的 在该国进行生物医学研究的绒猴经销商。对于研究人员来说，情况更是可怕 他们需要接触年老的绒猴认识到这样的瓶颈，NIH最近资助了两只绒猴 育种计划，包括本申请的亲本奖励（“Bicoastal Marmoset Breeding Center”，U24- MH123423）。拟议项目的目标是填补老龄绒猴可用性的差距， 阿尔茨海默病及其相关痴呆症的研究。我们可以利用这个中心来开发 用于老年痴呆症的研究。这一资源对科学界来说将是极其宝贵的 研究阿尔茨海默病及其相关痴呆症的社区。