Bicoastal Marmoset Breeding Center

非人灵长类动物是研究阿尔茨海默病及其相关疾病的重要动物模型 痴呆症是因为他们与人类在进化上最接近的亲戚，他们在解剖学上是相同的， 生理和基因相互作用的特点。常见的绒猴(Callithrix Jacchus)是一种NHP模型 老龄化研究日益重要。这种新的世界灵长类动物为 老龄化和衰老相关疾病的研究，包括其在所有使用的NHP中相对较短的寿命 生物医学研究。越来越多的调查人员目前正在使用或将使用 喜欢用绒猴作为模型系统来研究衰老和包括阿尔茨海默氏症在内的与年龄相关的疾病 疾病。然而，这一领域的研究存在着明显的瓶颈。目前还没有可靠的 国内生物医学研究用绒猴的分销商。对于研究人员来说，情况甚至更可怕 他们需要接触老化的绒猴。认识到这样一个瓶颈，美国国立卫生研究院最近资助了两只绒猴 育种计划，包括本申请的父母奖(“双海岸马毛赛特育种中心”，U24- MH123423)。拟议项目的目标是填补老年绒猴供应方面的空白 阿尔茨海默病及其相关痴呆的研究。我们可以利用这个中心来开发资源 用于阿尔茨海默病研究的老化绒猴。这一资源对科学工作者来说将是极其宝贵的 研究阿尔茨海默病及其相关痴呆的社区。

Nonhuman primates (NHP) are crucial animal models for research on Alzheimer’s disease and its related dementias because of their closest evolutionary relatives of humans, with whom they share anatomical, physiological, and gene interactions features. The common marmoset (Callithrix jacchus) is a NHP model of increasing importance for aging research. This new world primate provides some unique advantages for the study of aging and aging-related disorders, including its relatively short lifespan among all the NHP used in biomedical research. There has been an increasing number of investigators who are currently using or would like to use marmosets as a model system to study aging and age-related diseases including Alzheimer’s disease. However, there is a significant bottleneck for the research in this field. There are currently no reliable distributors of marmosets for biomedical research in the country. The situation is even direr for researchers who need access to aging marmosets. Recognizing such a bottleneck, NIH has recently funded two marmoset breeding programs including the parent award of this application (“Bicoastal Marmoset Breeding Center”, U24- MH123423). The goal of the proposed project is to fill the gap in the availability of aging marmosets for the study of Alzheimer’s disease and its related dementias. We could use this center to develop a resource of aging marmosets for Alzheimer's disease studies. This resource will be extremely valuable to the scientific community studying Alzheimer's disease and its related dementias.