Bicoastal Marmoset Breeding Center

双海岸狨猴繁育中心

基本信息

批准号：
10401871
负责人：
XIAOQIN WANG
金额：
$ 109.91万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-05-31
项目状态：
未结题

项目摘要

Project Summary The common marmoset (Callithrix jacchus) has experienced unprecedented growth in research across the United States and is rapidly emerging as a likely keystone biomedical model system in the next chapter of scientific discovery. Over the past decade, the number of marmoset laboratories in the US has quadrupled. There are now over 40 Principal Investigators who use marmoset as the model system in their research. Neuroscience is the primary engine driving marmoset research today, as nearly three quarters of marmoset researchers in the US use this model species to examine molecular, systems or cognitive functions in normal and diseased brains. Although these grassroots have been successfully forged new paths of scientific inquiry using marmosets in the U.S., critical bottlenecks have emerged that threaten to thwart the continued growth of this emerging model system. We propose to establish a Bicoastal Marmoset Breeding center, with two breeding colonies, one on the East Coast at Johns Hopkins University (JHU) and the other on the West Coast at University of California at San Diego (UCSD). The Center aims to produce a large number of marmosets to supply the marmoset research community in the U.S. Because of the non-availability of air transport of NHP in U.S. and prohibitively expensive ground transportation of NHP between the east and west coast, these two breeding colonies are strategically located to support the marmoset community in regions near each colony. We believe such a center is needed to address the national shortage of marmosets in order for the marmoset model to realize its full potential as a keystone species in the next chapter of neuroscience that serves to accelerate the rate of discovery and better understand human neurological disease.

项目摘要普通的摩尔摩斯特（Callithrix jacchus）在整个研究中的研究中经历了前所未有的增长美国，并在下一章中迅速成为可能的Keystone生物医学模型系统科学发现。在过去的十年中，美国的Marmoset实验室数量已经三倍。现在，有40多名首席研究人员在其研究中使用Marmoset作为模型系统。神经科学是当今驱动摩尔马斯研究的主要发动机，因为近四分之三美国的研究人员使用该模型物种检查正常的分子，系统或认知功能和患病的大脑。尽管这些基层已成功地锻造了科学探究的新途径在美国使用摩尔果会，出现了关键的瓶颈，威胁着挫败持续增长这个新兴模型系统。我们建议建立一个双层果酱中心，有两个繁殖殖民地，一个在约翰·霍普金斯大学（JHU）的东海岸，另一个在西海岸在加利福尼亚大学圣地亚哥分校（UCSD）。该中心旨在生产大量摩尔由于NHP的航空运输不可用美国以及东海岸之间NHP的昂贵地面运输，这两个繁殖菌落地理位置优越，以支持每个殖民地附近地区的Marmoset社区。我们认为，需要这样的中心来解决国家短缺的摩尔马斯群岛的短缺在下一章的神经科学中，实现其作为基石物种的全部潜力的模型，该物种有助于加速发现率并更好地了解人类神经系统疾病。