Bicoastal Marmoset Breeding Center

双海岸狨猴繁育中心

• 批准号: 10401871
• 负责人: XIAOQIN WANG
• 金额: $ 109.91万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10401871
• 关键词: Address; Air; Animals; Area; Automobile Driving; Biological Models; Brain Diseases; Breeding; California; Callithrix; Callithrix jacchus jacchus; Colorado; Communities; Country; Fostering; Funding; Genetic Variation; Growth; Human; Institutes; Investments; Japan; Laboratories; Modeling; Molecular; Neurosciences; Neurosciences Research; Paper; Population; Principal Investigator; Production; Request for Applications; Research; Research Personnel; Resources; Scientific Inquiry; Ships; Surveys; System; Techniques; Transportation; United States; Universities; animal resource; cognitive function; cost; design; experience; genetic manipulation; improved; meetings; nervous system disorder; neuropsychiatric disorder; programs; public health relevance; technique development

Project Summary The common marmoset (Callithrix jacchus) has experienced unprecedented growth in research across the United States and is rapidly emerging as a likely keystone biomedical model system in the next chapter of scientific discovery. Over the past decade, the number of marmoset laboratories in the US has quadrupled. There are now over 40 Principal Investigators who use marmoset as the model system in their research. Neuroscience is the primary engine driving marmoset research today, as nearly three quarters of marmoset researchers in the US use this model species to examine molecular, systems or cognitive functions in normal and diseased brains. Although these grassroots have been successfully forged new paths of scientific inquiry using marmosets in the U.S., critical bottlenecks have emerged that threaten to thwart the continued growth of this emerging model system. We propose to establish a Bicoastal Marmoset Breeding center, with two breeding colonies, one on the East Coast at Johns Hopkins University (JHU) and the other on the West Coast at University of California at San Diego (UCSD). The Center aims to produce a large number of marmosets to supply the marmoset research community in the U.S. Because of the non-availability of air transport of NHP in U.S. and prohibitively expensive ground transportation of NHP between the east and west coast, these two breeding colonies are strategically located to support the marmoset community in regions near each colony. We believe such a center is needed to address the national shortage of marmosets in order for the marmoset model to realize its full potential as a keystone species in the next chapter of neuroscience that serves to accelerate the rate of discovery and better understand human neurological disease.

项目摘要 普通绒猴（Callithrix jacchus）的研究经历了前所未有的增长， 美国，并迅速成为下一章可能的基石生物医学模型系统， 科学发现在过去的十年里，美国的绒猴实验室数量翻了两番。 现在有40多名首席研究员使用绒猴作为他们研究的模型系统。 神经科学是今天推动绒猴研究的主要引擎，因为近四分之三的绒猴 美国的研究人员使用这种模式物种来检查正常人的分子，系统或认知功能。 和病态的大脑尽管这些草根已经成功地开辟了科学探索的新途径， 在美国使用绒猴，关键的瓶颈已经出现，威胁到阻碍的持续增长， 这个新兴的模型系统。我们建议建立一个双海岸绒猴繁殖中心， 一个在东海岸的约翰霍普金斯大学（JHU），另一个在西海岸 在圣地亚哥的加州大学（UCSD）。该中心旨在生产大量的绒猴， 由于在美国没有航空运输NHP， 美国以及东西海岸之间昂贵的NHP地面运输，这两个 繁殖群的位置是战略性的，以支持每个群附近地区的绒猴群落。 我们相信这样的一个中心是需要解决全国性的绒猴短缺， 模型，以实现其作为神经科学下一章关键物种的全部潜力， 加快发现速度，更好地了解人类神经疾病。